Interactions between selected bile salts and Triton X-100 or sodium lauryl ether sulfate

Abstract

BackgroundIn order to develop colloidal drug carriers with desired properties, it is important to determine physico-chemical characteristics of these systems. Bile salt mixed micelles are extensively studied as novel drug delivery systems. The objective of the present investigation is to develop and characterize mixed micelles of nonionic (Triton X-100) or anionic (sodium lauryl ether sulfate) surfactant having oxyethylene groups in the polar head and following bile salts: cholate, deoxycholate and 7-oxodeoxycholate.ResultsThe micellization behaviour of binary anionic-nonionic and anionic-anionic surfactant mixtures was investigated by conductivity and surface tension measurements. The results of the study have been analyzed using Clint's, Rubingh's, and Motomura's theories for mixed binary systems. The negative values of the interaction parameter indicate synergism between micelle building units. It was noticed that Triton X-100 and sodium lauryl ether sulfate generate the weakest synergistic interactions with sodium deoxycholate, while 7-oxodeoxycholate creates the strongest attractive interaction with investigated co-surfactants.ConclusionIt was concluded that increased synergistic interactions can be attributed to the larger number of hydrophilic groups at α side of the bile salts. Additionally, 7-oxo group of 7-oxodeoxycholate enhance attractive interactions with selected co-surfactants more than 7-hydroxyl group of sodium cholate.

Investigations on microstructural changes in pH responsive mixed micelles of Triton X-100 and bile salt

“…The micellization of binary mixture of bile salts and nonionic Tweens showed stronger synergism [45,46]. Mixed micellization of TX-100 + bile salts has also been reported [47,48]. Solvation dynamics in pure and mixed micelles of NaDC and TX-100 in presence of coumarin 480 has been studied by picosecond time-resolved emission spectroscopy [48].…”

“…Solvation dynamics in pure and mixed micelles of NaDC and TX-100 in presence of coumarin 480 has been studied by picosecond time-resolved emission spectroscopy [48]. Ćirin et al [47] have studied the interaction of TX-100 with NaC, NaDC and sodium 7-oxodeoxycholate using conductance and surface tension measurements. Regular solution theories for mixed micelles were applied for analysis of data which manifest that the extent of interaction largely depends on the number of hydrophilic groups on concave side of bile salts which form H-bond with EO group of TX-100 and contribute in synergism.…”

“…Two important bile salts NaC and NaDC are the most abundant in human body [1] and their solution behaviour in mixed systems with other conventional surfactants have been studied in detail [6,[34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]. Influence of these bile salts on aggregation characteristics of anionic [6, 34], cationic [35][36][37][38][39][40], zwitterionic [16,41] and nonionic surfactants [42][43][44][45][46][47][48] have been reported. Ueno et al [42] studied the physicochemical properties of mixed micelles formed by octaoxyethylene glycol mono n-decyl ether (C 10 E 8 ) and variety of bile salts using 1 H NMR spectroscopy and revealed that the magnitude of interaction mostly depends upon the number and position of -OH groups and the hydrophobicity of bile salt.…”

“…The interactions between nonionic surfactants and bile salts in aqueous solutions have been widely studied featuring the detrimental effect of bile salts on the aggregation of TX-100 in aqueous solutions[47,48]. Ćirin et al[47] have studied TX-100-bile salt mixed system with main focus on evaluation of interaction parameters (β) for using regular solution theories and revealed that TX-100 displays weak synergistic interactions with NaDC.…”

“…The interactions between nonionic surfactants and bile salts in aqueous solutions have been widely studied featuring the detrimental effect of bile salts on the aggregation of TX-100 in aqueous solutions[47,48]. Ćirin et al[47] have studied TX-100-bile salt mixed system with main focus on evaluation of interaction parameters (β) for using regular solution theories and revealed that TX-100 displays weak synergistic interactions with NaDC. The main objective of this study was to understand the variations in microstructures of TX-100 micelles in the presence of bile salt (NaDC), with a special attention on the effect of pH, considering typical role of bile acids and it's corresponding salt during the digestion processes.…”