Interactions between reserpine, chlorpromazine, and imipramine

Costa, E.; Garattini, Silvio; Valzelli, L.

doi:10.1007/bf02171155

Cited by 140 publications

(28 citation statements)

References 6 publications

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“…The membrane stabilising actions may well be operating when chlorpromazine acts in therapeutic concentrations in vivo. These actions may explain why, for example, chlorpromazine counteracts the reserpine-induced decrease of the monoamines in some experiments Costa, Garattini & Valzelli, 1960).…”

Section: Release Of 5-hydroxytryptamine From Blood Plateletsmentioning

confidence: 92%

Release of 5-hydroxytryptamine from blood platelets

Paasonen

1965

Journal of Pharmacy and Pharmacology

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Section: Release Of 5-hydroxytryptamine From Blood Plateletsmentioning

confidence: 92%

Release of 5-hydroxytryptamine from blood platelets

Paasonen

1965

Journal of Pharmacy and Pharmacology

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“…Submissive and dominant rats were continuing to be tested in both paradigms for the next 3 weeks (weeks [3][4][5]. During that time all tested rats were receiving daily intraperitoneal injections of water.…”

Section: Characteristics Of Dominant-submissive Behavior In the Rsbmmentioning

confidence: 99%

“…They exhibit biochemical or behavioral responses to drugs or environmental conditions that are selectively reversed by antidepressant treatment [for review see 1, 2]. Examples of models using druginduced effects include inhibition of noradrenaline release from cerebral cortical slices by antidepressants [3]; amphetamine-, clonidine-, or reserpine-induced hypothermia; reversal of reserpine-induced ptosis or catalepsy [4][5][6][7], and clonidine-induced reversal of dominance behavior (CRDM) [8]. These models assume specific mechanisms of depression and antidepressant drug action.…”

Section: Introductionmentioning

confidence: 99%

Reduction of Submissive Behavior in Rats: A Test for Antidepressant Drug Activity

et al. 2001

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Randomly paired rats were food deprived overnight and placed in an apparatus compelling them to compete for a food reward. About half of these pairs developed a dominant-submissive relationship measured as a significant difference in time spent on the feeder by each rat. This relationship developed over a 2-week period and remained stable for at least the next 5 weeks. Treatment of the submissive subjects, for at least 2 weeks, with imipramine, desipramine, or fluoxetine (10 mg/kg) significantly reduced submissive behavior. The effect faded after cessation of treatment with desipramine. Fluoxetine was further tested at 2.5- and 5-mg/kg doses and showed a dose-dependent reduction of submissive behavior. Treatment of submissive rats with the anxiolytic diazepam (1 mg/kg) was ineffective. The prevalence of dominant-submissive relationships and the effect of desipramine and imipramine on submissive behavior were gender independent. The predictive, face, and construct validity of the behavioral test is discussed.

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“…The present work extends the above observations on L-DOPA-induced arousal in rabbits. In one experiment, the effect of histidine was also tested following the reversal of the sedative effect of reserpine by ©) Macmillan Journals Ltd 1979 imipramine (Costa, Garattini & Valzelli, 1960;Sulser, Watts & Brodie, 1961;Maxwell & Palmer, 1961). Imipramine is known to block the active reuptake of monoamines by nerve terminals, thereby potentiating their action at postsynaptic receptor sites (Schildkraut, 1965).…”

Section: Introductionmentioning

confidence: 99%

Reversal of Dopa-Induced Arousal in Reserpine-Treated Rabbits and Mice by Histidine

Abou

Farjo

1979

British Journal of Pharmacology

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1 The behavioural effects induced by histidine were studied in two species. In rabbits, sedation was assessed by the presence of blepharospasm, loss of righting reflex, and loss of response to painful stimuli. In mice, sedation and arousal were assessed by changes in the locomotor activity, exploratory activity, and minimal electroshock seizure threshold. 2 The administration of histidine to normal rabbits or mice, in doses of 800 mg/kg and 1000 mg/kg respectively, had no apparent effect on behaviour. Moreover, it did not affect the behavioural excitation induced by L-DOPA (100 mg/kg i.v. in rabbits and 750 mg/kg i.p. in mice) in these animals. 3 The administration of histidine with or after L-DOPA in reserpine-treated rabbits (2.5 mg/kg i.v.) or mice (5 mg/kg, i.p.) produced sedation. This sedative effect was dose-dependent. 4 The sedative effects induced by histidine after DOPA-induced arousal in reserpine-treated rabbits and mice were prevented by prior injection of the histamine H1-receptor blockers, chlorpheniramine (2.5 mg/kg) or diphenhydramine (5 mg/kg). 5 Imipramine (7 to 10 mg/kg, i.v.)induced arousal in reserpine-treated rabbits was also reversed by histidine infusion. 6 The infusion of 5-hydroxytryptophan (100 mg/kg, i.v.) with L-DOPA, or of arginine (450 mg/kg, i.v.) with or after L-DOPA, or of histamine (100 gg/kg), i.v.) after L-DOPA, did not affect the DOPA-induced arousal in reserpine-treated rabbits. 7 These findings indicate that histamine, formed centrally from exogenous histidine, and released in increased amounts at the synapses in reserpine-treated animals, possesses a central sedative effect. This effect may be sufficient to antagonize the behavioural excitation induced by high levels of catecholamines in the brain of these animals when aroused by L-DOPA administration. 8 It is concluded that in addition to the other monoamines, histamine may also be implicated in the regulation of brain excitability.

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Interactions between reserpine, chlorpromazine, and imipramine

Cited by 140 publications

References 6 publications

Release of 5-hydroxytryptamine from blood platelets

Release of 5-hydroxytryptamine from blood platelets

Reduction of Submissive Behavior in Rats: A Test for Antidepressant Drug Activity

Reversal of Dopa-Induced Arousal in Reserpine-Treated Rabbits and Mice by Histidine

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