Interactions between rat submucosal neurons and mast cells are modified by cytokines and neurotransmitters

Ballout, Jasmin; Diener, Martin

doi:10.1016/j.ejphar.2019.172713

Cited by 8 publications

(4 citation statements)

References 58 publications

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“…MCs are effectors of the brain–gut axis that produce neurotransmitters and pro-inflammatory cytokines in response to stress signals to regulate the permeability of the intestinal epithelial barrier via the HPA axis ( 81 ). Animal experiments have shown that chronic psychological stress-induced CRH is released by the hypothalamus and binds to MC CRHR-1 to induce activation and degranulation of MC and increase the permeability of the intestinal epithelium while blocking CRH release inhibits MC degranulation and the production of TNF-α and protease, which delays the impairment of intestinal barrier.…”

Section: Chronic Psychological Stress Disturbs Intestinal Immune Func...mentioning

confidence: 99%

Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications

Liu²,

Li³

et al. 2022

Front. Immunol.

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Inflammatory bowel disease (IBD), mainly including ulcerative colitis (UC) and Crohn’s disease (CD), is an autoimmune gastrointestinal disease characterized by chronic inflammation and frequent recurrence. Accumulating evidence has confirmed that chronic psychological stress is considered to trigger IBD deterioration and relapse. Moreover, studies have demonstrated that patients with IBD have a higher risk of developing symptoms of anxiety and depression than healthy individuals. However, the underlying mechanism of the link between psychological stress and IBD remains poorly understood. This review used a psychoneuroimmunology perspective to assess possible neuro-visceral integration, immune modulation, and crucial intestinal microbiome changes in IBD. Furthermore, the bidirectionality of the brain–gut axis was emphasized in the context, indicating that IBD pathophysiology increases the inflammatory response in the central nervous system and further contributes to anxiety- and depression-like behavioral comorbidities. This information will help accurately characterize the link between psychological stress and IBD disease activity. Additionally, the clinical application of functional brain imaging, microbiota-targeted treatment, psychotherapy and antidepressants should be considered during the treatment and diagnosis of IBD with behavioral comorbidities. This review elucidates the significance of more high-quality research combined with large clinical sample sizes and multiple diagnostic methods and psychotherapy, which may help to achieve personalized therapeutic strategies for IBD patients based on stress relief.

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Section: Chronic Psychological Stress Disturbs Intestinal Immune Func...mentioning

confidence: 99%

Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications

Liu²,

Li³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…The number of mast cells in the intestinal mucosa of IBD patients was significantly higher than that of healthy people. More studies have shown that the mast cell was involved in the occurrence and development of IBD [60]. When activated, mast cells play a significant part in the inflammatory response process of UC by releasing various inflammatory compounds such as histamine, chemokines, etc.…”

Section: Inhibition Of Mast Cell Degranulationmentioning

confidence: 99%

Pomegranate (Punica granatum L.) and Its Rich Ellagitannins as Potential Inhibitors in Ulcerative Colitis

Li,

Ruan,

Huang

et al. 2023

IJMS

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Ulcerative colitis, an immune-mediated inflammatory disease of the gastrointestinal tract, places a significant financial burden on patients and the healthcare system. Recently, reviews of the pomegranate and the abundant medicinal applications of its ellagitannins, as well as its pharmacological action, phytochemicals, metabolism, and pharmacokinetics, have been completed. However, summaries on their anti-ulcerative colitis effects are lacking. Numerous preclinical animal investigations and clinical human trial reports demonstrated the specific therapeutic effects of pomegranate and the effect of its ellagitannins against ulcerative colitis. According to the literature collected by Sci-finder and PubMed databases over the past 20 years, this is the first review that has compiled references regarding how the rich ellagitannins found in pomegranate have altered the ulcerative colitis. It was suggested that the various parts of pomegranates and their rich ellagitannins (especially their primary components, punicalagin, and ellagic acid) can inhibit oxidant and inflammatory processes, regulate the intestinal barrier and flora, and provide an anti-ulcerative colitis resource through dietary management.

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“…They strengthen the relationship among mast cells, trypsin, neuroinflammation and neuronal death ( 39 – 41 ). After co-culture of intestinal secretory neurons with mast cells, mast cells release histamine and protease through degranulation resulting in increased intra-neuronal Ca2+ concentration and significantly increased neuronal sensitivity, but the function of mast cells themselves is inhibited ( 42 ).…”

Section: Regulation Of Intestinal Nervous System On Immune Cellsmentioning

confidence: 99%

Neuroimmune regulation in Hirschsprung’s disease associated enterocolitis

Lai

Tou

2023

Front. Immunol.

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Neuroimmune pathways are important part of the regulation of inflammatory response. Nerve cells regulate the functions of various immune cells through neurotransmitters, and then participate in the inflammatory immune response. Hirschsprung’s disease (HD) is a congenital abnormal development of intestinal neurons, and Hirschsprung-associated enterocolitis (HAEC) is a common complication, which seriously affects the quality of life and even endangers the lives of children. Neuroimmune regulation mediates the occurrence and development of enteritis, which is an important mechanism. However, there is a lack of review on the role of Neuroimmune regulation in enterocolitis associated with Hirschsprung’s disease. Therefore, this paper summarizes the characteristics of the interaction between intestinal nerve cells and immune cells, reviews the neuroimmune regulation mechanism of Hirschsprung’s disease associated enterocolitis (HAEC), and looks forward to the potential clinical application value.

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Interactions between rat submucosal neurons and mast cells are modified by cytokines and neurotransmitters

Cited by 8 publications

References 58 publications

Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications

Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications

Pomegranate (Punica granatum L.) and Its Rich Ellagitannins as Potential Inhibitors in Ulcerative Colitis

Neuroimmune regulation in Hirschsprung’s disease associated enterocolitis

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