Interactions between poly(ethylene glycol) and protein in dichloromethane/water emulsions. 2. Conditions required to obtain spontaneous emulsification allowing the formation of bioresorbable poly(d,l lactic acid) microparticles

Malzert‐Fréon, Aurélie; Schönhammer, Karin; Benoı̂t, Jean-Pierre; Boury, Frank

doi:10.1016/j.ejpb.2009.04.011

Cited by 3 publications

(5 citation statements)

References 34 publications

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“…These results are quite the same as those measured values for the corresponding PE/PC. These results show the reverse micelles structures can prevent aggregation of the encapsulated molecules (i.e., VEGF and MNSs) …”

Section: Resultsmentioning

confidence: 79%

“…As shown in Figures K,L, a rapid decrease is observed in the surface tension of Mg(OH) 2 , MNSs, and native VEGF samples. This phenomenon can be related to the self-aggregation and absorption of samples on the interfacial layer. , After this sudden drop, the adsorption equilibrium in samples with a small variation in the surface tension has been reached. At the equilibrium condition, the additional layers are formed through molecular rearrangement, i.e., the aggregation of the individual molecules, intermolecular association, or 2D precipitation. , In the oil/water emulsions, such aggregation in the molecules creates a continuous coating layer at the o/w interface .…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Figures 2K,L This phenomenon can be related to the self-aggregation and absorption of samples on the interfacial layer. 36,37 After this sudden drop, the adsorption equilibrium in samples with a small variation in the surface tension has been reached. At the equilibrium condition, the additional layers are formed through molecular rearrangement, i.e., the aggregation of the individual molecules, intermolecular association, or 2D precipitation.…”

Section: Resultsmentioning

confidence: 99%

“…The pendant drop tensiometry method (FTÅ, First Ten Angstroms) was used to study the adsorption kinetics of the RM nanoparticles at the water/DCM interface. , Briefly, 0.1 mg of PE/PC, Mg(OH) 2 , MNSs, MNS-RM, VEGF-RM, or native VEGF was suspended in 5 mL of DCM. Then, each sample was injected into an optical glass cuvette containing PVA solutions (2% w/v PVA solution in PBS) to form a pendant drop.…”

Section: Materials and Methodsmentioning

confidence: 99%

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Impact of Lipid/Magnesium Hydroxide Hybrid Nanoparticles on the Stability of Vascular Endothelial Growth Factor-Loaded PLGA Microspheres

Omidi

Mansouri

Amirabad

2021

ACS Appl. Mater. Interfaces

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The purpose of the present study is to characterize poly(D,L-lactide-co-glycolide) (PLGA) composite microcarriers for vascular endothelial growth factor (VEGF) delivery. To reduce the initial burst release and protect the bioactivity, VEGF is encapsulated in soybean L-α-phosphatidylethanolamine (PE) and L-α-phosphatidylcholine (PC) anhydrous reverse micelle (VEGF-RM) nanoparticles. Also, mesoporous nano-hexagonal Mg(OH) 2 nanostructure (MNS)-loaded PE/PC anhydrous reverse micelle (MNS-RM) nanoparticles are synthesized to suppress the induced inflammation of PLGA acidic byproducts and regulate the release profile. The flow-focusing microfluidic geometry platforms are used to fabricate different combinations of PLGA composite microspheres (PLGA-CMPs) with MNSs, MNS-RM, VEGF-RM, and native VEGF. The essential parameters of each formulation, such as release profiles, encapsulation efficacy, bioactivity, inflammatory response, and cytotoxicity, are investigated by in vitro and in vivo studies. The results indicate that generated acidic byproducts during the hydrolytic degradation process of PLGA can be buffered, and pH values inside and outside microspheres can remain steady during degradation by MNSs. Furthermore, the significant improvement in the stability of the encapsulated VEGF is confirmed by the bioactivity assay. In vitro release study shows that the VEGF initial burst release is well minimized in the present microcarriers. The present monodisperse PLGA-CMPs can be widely used in various tissue engineering and therapeutic applications.

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Section: Resultsmentioning

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Materials and Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Impact of Lipid/Magnesium Hydroxide Hybrid Nanoparticles on the Stability of Vascular Endothelial Growth Factor-Loaded PLGA Microspheres

Omidi

Mansouri

Amirabad

2021

ACS Appl. Mater. Interfaces

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“…The smaller the pH, the larger the emulsion particle size, indicating that a high pH was conducive to smaller droplets and more stable kinetically emulsions. Additionally, it was observed that emulsification primarily occurred due to the diffusion of the in situ emulsifier from the oil to aqueous phase, owing to the formation of interfacial turbulences [62] or diffusion and the stranding mechanism. BetS-2 emulsifier exhibited no effect on the formation of droplets, and it was mainly used to stabilize the droplets.…”

Section: The Effect Of Ph On the Emulsification Processmentioning

confidence: 99%

Factors, Mechanisms, and Kinetics of Spontaneous Emulsification for Heavy Oil-in-Water Emulsions

Liu,

Li,

Lun

et al. 2024

Molecules

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In challenging reservoirs where thermal recovery falls short, cold or chemical oil recovery methods are crucial. Spontaneous emulsification (SE), triggered by gentle disturbance, significantly enhances oil recovery. In elucidating SE mechanisms and kinetics, SE processes via direct contact between oil and aqueous phases without stirring were conducted. The effects of temperature, emulsifier concentration, pH, NaCl concentration, and the oil-to-water ratio on SE were investigated through droplet size analysis and turbidity measurements. Furthermore, the emulsification mechanism and derived emulsification kinetics based on turbidity data were obtained. The results underscore the feasibility of SE for oil–water systems, reducing viscous and capillary resistances without agitation. The emulsified oil mass increased with the temperature, pH, and aqueous-to-oil phase volume ratio while decreasing with the NaCl concentration. In this study, for GD-2 crude oil, the optimal emulsified oil amount occurred at a betaine surfactant (BetS-2) emulsifier concentration of 0.45%. Microscopic photo analysis indicated narrow particle size distributions and small droplets, which remained stable over time under various experimental conditions. A combined SE mechanism involving ultralow interfacial tension, interfacial turbulence due to Marangoni effects, and “diffusion and stranding” due to in situ emulsifier hydrophilicity, was speculated. Additionally, an analogous second-order kinetic equation for SE was proposed, indicating exceptional correlation with calculated and experimentally measured values. This study offers theoretical insight for enhancing oil recovery in chemical and cold production of heavy oil in oilfields.

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A facile method to functionalize gold nano-tripods with high suspension stability in an aqueous environment

et al. 2018

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Here we aim to develop a facile emulsion-based method to prepare tripod gold nanoparticles (AuNPs) with high suspension stability in an aqueous environment. A gyroid-structured polymer template formed by the hydrolysis of a degradable block copolymer, polystyrene (PS)-b-poly(l-lactide), is used for the fabrication of AuNPs. Also, a successful emulsification of dichloromethane (DCM) in the aqueous phase is developed by using thiolated polyethylene glycol (PEG-SH) as the stabilizer. Subsequently, the nanohybrids of PS/Au can be fabricated by templated electroless plating, and then selectively dissolving in the DCM dispersive phase. Most interestingly, a dedicated process for the simultaneous release of the tripod AuNPs from the dissolution of PS associated with PEG-SH at the interface of the emulsion is achieved, giving PEG-SH-functionalized tripod AuNPs dispersed in the aqueous phase, which significantly improves the suspension stabilization of tripod AuNPs. The in situ temperature-programmed electrospray-differential mobility analysis provides a quantitative, statistical analysis of mobility diameter, dynamic shape factor, polydispersity, and colloidal stability.

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Interactions between poly(ethylene glycol) and protein in dichloromethane/water emulsions. 2. Conditions required to obtain spontaneous emulsification allowing the formation of bioresorbable poly(d,l lactic acid) microparticles

Cited by 3 publications

References 34 publications

Impact of Lipid/Magnesium Hydroxide Hybrid Nanoparticles on the Stability of Vascular Endothelial Growth Factor-Loaded PLGA Microspheres

Impact of Lipid/Magnesium Hydroxide Hybrid Nanoparticles on the Stability of Vascular Endothelial Growth Factor-Loaded PLGA Microspheres

Factors, Mechanisms, and Kinetics of Spontaneous Emulsification for Heavy Oil-in-Water Emulsions

A facile method to functionalize gold nano-tripods with high suspension stability in an aqueous environment

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