Interactions between phytoestrogens and human sex steroid binding protein

Martin, M. E.; Haourigui, M.; Pelissero, C.; Benassayag, C.; Nunez, Emmanuel A.

doi:10.1016/0024-3205(95)02308-9

Cited by 150 publications

(85 citation statements)

References 25 publications

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“…This early study was later followed by many others, which evaluated the estrogenic activity of nutritional flavonoids. It has been reported that genistein and equol impair E2 and testosterone binding to human sex hormone binding globulin relevant for hormone occurrence in the blood stream (Martin et al, 1996). Thus, genistein and other flavonoids could potentially affect clearance rates of sex steroid hormones and therefore the availability of the E2 to target cells (Martin et al, 1996;Oh et al, 2005).…”

Section: Fl Fl Fl Fl Fla a A A Av V V V Vonoid Estr Onoid Estr Onoid mentioning

confidence: 99%

“…It has been reported that genistein and equol impair E2 and testosterone binding to human sex hormone binding globulin relevant for hormone occurrence in the blood stream (Martin et al, 1996). Thus, genistein and other flavonoids could potentially affect clearance rates of sex steroid hormones and therefore the availability of the E2 to target cells (Martin et al, 1996;Oh et al, 2005). In 1997 the Organization for Economic Cooperation and Development (OECD) initiated a high priority activity to develop new and revised guidelines for screening and testing the estrogenicity of potential endocrine disrupters (OECD, 1998).…”

Section: Fl Fl Fl Fl Fla a A A Av V V V Vonoid Estr Onoid Estr Onoid mentioning

confidence: 99%

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Nutritional flavonoids impact on nuclear and extranuclear estrogen receptor activities

Galluzzo

Marino

2006

Genes Nutr

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Section: Fl Fl Fl Fl Fla a A A Av V V V Vonoid Estr Onoid Estr Onoid mentioning

confidence: 99%

Section: Fl Fl Fl Fl Fla a A A Av V V V Vonoid Estr Onoid Estr Onoid mentioning

confidence: 99%

Nutritional flavonoids impact on nuclear and extranuclear estrogen receptor activities

Galluzzo

Marino

2006

Genes Nutr

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“…Micromolar concentrations are required for lignan and isoflavone binding to SHBG (5-50 µM) (38) and α-fetoprotein (K d : 0.5-5 µM) (57,58). Concentrations required for inhibition of most steroid metabolizing enzymes are generally in the micromolar range, with the exception 17β-hydroxysteroid dehydrogenase type I, which is inhibited by isoflavonoids at concentrations ranging from 120 nM to 1 µM (33,59).…”

Section: Phytoestrogen Potencies and Active Concentrationsmentioning

confidence: 99%

Cross-species and interassay comparisons of phytoestrogen action.

Whitten

Patisaul

2001

Environ Health Perspect

174

105

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This paper compiles animal and human data on the biologic effects and exposure levels of phytoestrogens in order to identify areas of research in which direct species comparisons can be made. In vitro and in vivo assays of phytoestrogen action and potency are reviewed and compared to actions, dose-response relationships, and estimates of exposure in human subjects. Binding studies show that the isoflavonoid phytoestrogens are high-affinity ligands for estrogen receptors (ERs), especially ER beta, but have lower potency in whole-cell assays, perhaps because of interactions with binding proteins. Many other enzymatic actions require concentrations higher than those normally seen in plasma. In vivo data show that phytoestrogens have a wide range of biologic effects at doses and plasma concentrations seen with normal human diets. Significant in vivoresponses have been observed in animal and human tests for bone, breast, ovary, pituitary, vasculature, prostate, and serum lipids. The doses reported to be biologically active in humans (0.4--10 mg/kg body weight/day) are lower than the doses generally reported to be active in rodents (10--100 mg/kg body weight/day), although some studies have reported rodent responses at lower doses. However, available estimates of bioavailability and peak plasma levels in rodents and humans are more similar. Steroidogenesis and the hypothalamic-pituitary-gonadal axis appear to be important loci of phytoestrogen actions, but these inferences must be tentative because good dose-response data are not available for many end points. The similarity of reported proliferative and antiproliferative doses illustrates the need for fuller examination of dose-response relationships and multiple end points in assessing phytoestrogen actions.

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“…11,12 Equol and isoflavones have a binding affinity estrogen receptor b. 13,14 Additionally, equol can bind sex hormone-binding globulin 15,16 and 5a-dihydrotestosterone 14 and inhibit the growth of prostate cells in vitro and in vivo. 14,17 Therefore, equol can act as an anti-androgen and inhibit the development of sex hormone-dependent tumors such as breast cancer and prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

Age-stratified serum levels of isoflavones and proportion of equol producers in Japanese and Korean healthy men

Fujimoto

Tanaka

Hirao

et al. 2008

Prostate Cancer Prostatic Dis

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Racial differences in the incidence of prostate cancer are manifest worldwide, possibly due to the different dietary habits. To elucidate the relationship between the recent trend of phytoestrogenic isoflavone intake and the increased incidence of prostate cancer in Japan, we conducted an agestratified dietary survey of soybean foods in 102 Japanese healthy men (age range: 10-59 years) and measured the serum isoflavones and equol levels in them and 100 Korean healthy men. The intergroup comparison among the age-stratified groups showed significant differences in the daily intake of genistein and daidzein between the teenager group and the other groups of age^30 years (Po0.05). In the Japanese study, the proportion of equol producers in the teenager group was 10%, being significantly the lowest among the age-stratified groups. The proportions of equol producers in the age-stratified groups from 10 to 49 years were also significantly lower than those in the fifties. The equol non-producers consumed significantly less amounts of isoflavones than the equol producers. In the Korean study, the proportions of equol producers were 45% in the teenager and 40% in the twenties and thirties, being significantly lower than in the forties (80%) and fifties (65%). The decreased intake of isoflavones, low serum level of equol and low incidence of equol production in the young generation may become potential risk factors for prostate cancer not only in Japan but also in Korea in the near future. Elucidating the mechanism of equol production may be promising in developing strategies for chemoprevention against prostate cancer.

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Interactions between phytoestrogens and human sex steroid binding protein

Cited by 150 publications

References 25 publications

Nutritional flavonoids impact on nuclear and extranuclear estrogen receptor activities

Nutritional flavonoids impact on nuclear and extranuclear estrogen receptor activities

Cross-species and interassay comparisons of phytoestrogen action.

Age-stratified serum levels of isoflavones and proportion of equol producers in Japanese and Korean healthy men

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