Interactions between mitochondria-damaging platinum(iv) prodrugs and cytochrome c

Abstract

In this work, we present the first study about the interactions of mitochondria-damaging Pt(IV) prodrugs with cytochrome c. We synthesized a cisplatin-based Pt(IV) prodrug bearing a lipophilic hydrocarbon tail and...

Evaluation of markers of apoptotic processes and peroxide oxidation of lipids of the mitochondrial fraction of the liver of animals carrying Lewis epidermoid carcinoma at different stages of the development of the tumor process with the introduction of organotin compounds with a tread fragment

“…Амфифильная структура противоопухолевых агентов способствует его накоплению в митохондриях раковых клеток [17], что вызывает накопление окислительных нуклеиновых кислот в цитоплазме [18]. Опухолевая агрессия увеличивает продукцию митохондриальных АФК, ПОЛ, снижая потенциал митохондриальной мембраны [19].…”

Visible light-activatable platinum(iv) prodrugs harnessing CD36 for ovarian cancer therapy

“…Previous studies have demonstrated that lipophilic Pt(IV) prodrugs with hydrocarbon tails possess high potency and promising pharmacokinetics. [28][29][30][31][32][33][34][35][36] Our recent research has also shown that such prodrugs can utilize CD36 upregulation to effectively target ovarian cancer cells. 8 In this new project, we have modified the Pt(IV) prodrug by attaching a fluorescein moiety, which enables photoactivation upon 490 nm irradiation.…”

Ligand substitution reactions afford oxaliplatin-based platinum(iv) complexes bearing axial alkoxido ligands

“…24 The nucleophilic hydroxido ligands in platinum(IV) complexes can react with common organic electrophiles, including acid chloride, acid anhydride, NHS-esters, and isocyanates, to form well-designed platinum(IV) prodrugs. [25][26][27][28][29][30][31][32][33][34] Additionally, direct esterification of hydroxido ligands with carboxylic acids can occur with the assistance of coupling reagents. [35][36][37][38][39][40] Moreover, axial halogen ligands or an acetamidato ligand can be introduced by utilizing halogenation reagents (F•py, NCS, and NBS) in water or H 2 O 2 in mixed solvents (MeCN and MeOH); however, to further functionalize these asymmetric platinum(IV) complexes, the remaining axial hydroxido ligand must participate.…”