Interactions between Macrophages and Fungi

Shadomy, H. Jean; Fromtling, Robert A.

doi:10.1007/978-1-4899-3748-3_8

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1993

1997

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Cited by 2 publications

(1 citation statement)

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“…It also caused death due to toxicity in over 50% of uninfected mice at daily doses exceeding 25 mg/kg. 138 In another report,139 at daily doses of 20 mg/kg, hamycin was reported to protect mice with experimental cryptococcal infection.…”

Section: Hamycinmentioning

confidence: 98%

Opportunistic/nosocomial infections. Treatment and developmental therapeutics. II. cryptococcosis

Georgiev

1993

Medicinal Research Reviews

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Section: Hamycinmentioning

confidence: 98%

Opportunistic/nosocomial infections. Treatment and developmental therapeutics. II. cryptococcosis

Georgiev

1993

Medicinal Research Reviews

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Macrophages in resistance to candidiasis

Vázquez‐Torres

Balish

1997

Microbiol Mol Biol Rev

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Candida albicans, an increasingly common opportunistic pathogenic fungus, frequently causes disease in immunodeficient but not immunocompetent hosts. Clarifying the role of the phagocytic cells that participate in resistance to candidiasis not only is basic to understanding how the host copes with this dimorphic pathogen but also will expedite the development of innovative prophylactic and therapeutic approaches for treating the multiple clinical presentations that candidiasis encompasses. In this review, we present evidence that a diverse population of mononuclear phagocytes, in different states of activation and differentiation and from a variety of host species, can phagocytize C. albicans blastoconidia via an array of opsonic and nonopsonic mechanisms and can kill C. albicans blastoconidia and hyphae by means of oxygen-dependent and -independent mechanisms. Reactive nitrogen intermediates should now be added to the well-established candidacidal reactive oxygen intermediates of macrophages. Furthermore, what were thought to be two independent pathways, i.e., nitric oxide and superoxide anion, have now been shown to combine to form a potent macrophage candidacidal molecule, peroxynitrite. In contrast to monocytes and neutrophils, which are important in resistance to early stages of C. albicans infections, more differentiated macrophages activated by cytokines such as gamma interferon participate in the acquired resistance of hosts with C. albicans-specific, cell-mediated immunity. Evidence presented in this review demonstrates that mononuclear phagocytes, in some instances in the absence of other professional phagocytes such as neutrophils, play an import role in resistance to systemic and mucosal candidiasis.

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Interactions between Macrophages and Fungi

Cited by 2 publications

References 131 publications

Opportunistic/nosocomial infections. Treatment and developmental therapeutics. II. cryptococcosis

Opportunistic/nosocomial infections. Treatment and developmental therapeutics. II. cryptococcosis

Macrophages in resistance to candidiasis

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