Interactions between HIV and hepatitis B virus in homosexual men

Gilson, Richard; Hawkins, Amanda; Beecham, M; Ross, Emma; Waite, James; Briggs, Moya; McNally, Tracey; Kelly, Gabrielle; Tedder, Richard S.; Weller, I. V. D.

doi:10.1097/00002030-199705000-00007

Cited by 275 publications

(183 citation statements)

References 36 publications

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“…HIV/HCV can be found in eight to 30% of all HIV infected individuals 3,5,28,29,31,32,35 , and approximately 50 -92% of these are intravenous drug users. Similarly, evidence of past HBV infection can be as high as 50 -80% of all HIV infected individuals 8,15,16,19 . This prevalence varies depending on the geographical area and the risk of the studied population 3,5,8,15,16,17,28,29,31,32,35 .…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, evidence of past HBV infection can be as high as 50 -80% of all HIV infected individuals 8,15,16,19 . This prevalence varies depending on the geographical area and the risk of the studied population 3,5,8,15,16,17,28,29,31,32,35 .…”

Section: Introductionmentioning

confidence: 99%

“…HIV/HBV coinfected patients have a higher risk of developing cirrhosis related to HBV, exhibit higher levels of HBV replication, lower rates of spontaneous resolution of the HBV infection, higher risk of reactivation of previous infections, and higher liver toxicity associated with antiretroviral therapy 8,10,15,19 . Whether or not, HBV coinfection alters the course of HIV progression has also been a matter of discussion 8,11,15,19,34 .…”

Section: Introductionmentioning

confidence: 99%

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Serological markers and risk factors for hepatitis B and C viruses in patients infected with human immunodeficiency virus

Hoyos-Orrego

Massaro-Ceballos

Ospina-Ospina

et al. 2006

Rev. Inst. Med. trop. S. Paulo

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SUMMARYBoth hepatitis B and hepatitis C viruses (HBV and HCV) infection are common in HIV-infected individuals as a result of shared risk factors for acquisition. A serological study for HBV and HCV was performed in 251 HIV-positive individuals from Medellín, Colombia. A qualitative RT-PCR for HCV was done in 90 patients with CD4+ T-cell count ≤ 150 per mm 3 . Serological markers for HBV infection were present in 97 (38.6%) patients. Thirty six of them (37.1%) had isolated anti-HBc. A multivariate analysis indicated that the following risk factors were significantly associated with the presence of these markers: age (OR = 1.05, 95% CI: 1.01-1.08), pediculosis pubis (OR = 1.83, 95% CI: 1.01-3.33), men who have sex with men and women (OR = 3.23, 95% CI: 1.46-7.13) and men who have sex only with men (OR = 3.73, 95% CI: 1.58-8.78). The same analysis restricted to women showed syphilis as the only significant risk factor. Thus, HBV infection was considerably associated with high risk sexual behavior. HCV was present in only two (0.8%) of HIV patients. Both of them were positive by RT-PCR and anti-HCV. This low frequency of HIV/HCV coinfection was probably due to the uncommon intravenous drug abuse in this population. The frequent finding of isolated anti-HBc warrants molecular approaches to rule out the presence of cryptic HBV infection.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serological markers and risk factors for hepatitis B and C viruses in patients infected with human immunodeficiency virus

Hoyos-Orrego

Massaro-Ceballos

Ospina-Ospina

et al. 2006

Rev. Inst. Med. trop. S. Paulo

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“…The course of chronic HBV and HIV co-infection will present with higher levels of HBV DNA and lower rates of clearance of the hepatitis Be antigen (HBeAg) [35]. HIV increases the risk of cirrhosis and end-stage liver disease in HBV coinfection [36].…”

Section: Hiv/hbv Co-infectionmentioning

confidence: 99%

HIV Co-Infection with Hepatotropic Viruses and Mycobacterial Tuberculosis

BU¹

2013

J AIDS Clin Res

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“…6,7 Patients with chronic hepatitis B and underlying HIV infection (HIV-HBV co-infection) are also at higher risk of cirrhosis and hepatocellular carcinoma when compared with HBV-mono-infected individuals. 8 The ideal outcome of treatment for HBV would be to achieve HBsAg clearance with anti-HBs seroconversion, but this endpoint can be reached in only a few patients (fewer than 10% of HBV monoinfected patients have received interferon treatment, and probably even fewer HIV/HBV co-infected patients). A more realistic goal, therefore, is to efficiently and persistently suppress HBV replication and thus reduce the liver inflammation and scarring that can lead to liver cirrhosis and hepatocellular carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Treatment outcomes in a cohort of patients with chronic hepatitis B and human immunodeficiency virus co-infection in Mumbai, India

Isaakidis¹,

Mansoor²,

Zachariah³

et al. 2012

International Health

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CitationTreatment outcomes in a cohort of patients with chronic hepatitis B and human immunodeficiency virus coinfection in Mumbai, India 2012, 4 (4) Treatment experiences with patients co-infected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in resource-limited settings remain poorly documented.This study aimed to evaluate the treatment outcomes in a cohort of HIV/HBV co-infected individuals receiving tenofovir/lamivudine (TDF/3TC)-based antiretroviral therapy (ART) in a programmatic setting in Mumbai, India. Additionally, a cross-sectional laboratory study was carried out measuring serologic and virologic parameters. A total of 57 patients who received TDF/3TC were included in the study. Of these, 52 (91%) were male and the mean age was 38.7 years. The median follow-up period was 16.8 months (IQR:7.9-37.9). Forty-three patients were included in the cross-sectional laboratory study, of whom 38 (67%) were HBeAg + positive. Four patients had serum HBsAg conversion to negative and had developed anti-HBs-antibodies. HBV-DNA became undetectable (<1.3 log 10 copies/ml or <20 IU/ml) in 35.5% and 75% of the HBeAg + and HBeAg − patients, respectively. Overall, 46.5% of patients had undetectable HBV-DNA and 90.7% had adequately suppressed HBV-DNA (<3.3 log 10 copies/ml or <2000 IU/ml). The median reduction in serum HBV-DNA was 6 log 10 copies/ml. In 29 patients (63%) HIV viral load was undetectable. Outcomes included seven (12%) deaths, four (7%) lost to follow-up, one (2%) transferred out and 45 (79%) alive and on treatment. In conclusion, good treatment outcomes were achieved in a cohort of HIV/HBV co-infected patients in India. In regions with a high HIV/HBV burden, all HIV-infected individuals should be tested for chronic hepatitis B. A TDF/3TC-backbone could be considered as first-line standardized ART regimen in these settings.

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Interactions between HIV and hepatitis B virus in homosexual men

Cited by 275 publications

References 36 publications

Serological markers and risk factors for hepatitis B and C viruses in patients infected with human immunodeficiency virus

Serological markers and risk factors for hepatitis B and C viruses in patients infected with human immunodeficiency virus

HIV Co-Infection with Hepatotropic Viruses and Mycobacterial Tuberculosis

Treatment outcomes in a cohort of patients with chronic hepatitis B and human immunodeficiency virus co-infection in Mumbai, India

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