Interactions between genes involved in physiological dysregulation and axon guidance: role in Alzheimer’s disease
Konstantin G. Arbeev,
Svetlana Ukraintseva,
Olivia Bagley
et al.
Abstract:Dysregulation of physiological processes may contribute to Alzheimer’s disease (AD) development. We previously found that an increase in the level of physiological dysregulation (PD) in the aging body is associated with declining resilience and robustness to major diseases. Also, our genome-wide association study found that genes associated with the age-related increase in PD frequently represented pathways implicated in axon guidance and synaptic function, which in turn were linked to AD and related traits (e… Show more
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