Interactions between drugs and intravenous delivery systems

Kowaluk, Elizabeth A.; Roberts, Michael S.; Polack, Alan E.

doi:10.1093/ajhp/39.3.460

Cited by 22 publications

(26 citation statements)

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“…Extensive concentration-dependent losses are observed in both cases, confirming and extending previous reports (8,9). It can be concluded, by comparing the losses found in this study with those previously observed (8,9), that the loss of I was unaffected by the presence of trace amounts of radiolabeled diazepam. Significant I losses were also observed from solutions infused through polyvinyl chloride tubing (Fig.…”

Section: Resultssupporting

confidence: 91%

“…Kinetics of Sorption and Permeation-The sorption of clomethiazole edisylate (I) by polyvinyl chloride and cellulose propionate has been described previously as a diffusion-controlled process (8,9). According to the diffusion model, the rate and extent of sorption is determined by the plastic-water partition coefficient of the solute and its diffusion ae lo0l 80 Table I.…”

Section: (A) (B) Rate Constants For the Evaporation Of I Across The mentioning

confidence: 99%

“…3) is consistent with the plastic acting as a semi-infinite sink over this time. Kowaluk et al (9) have reported that the sorption of a number of other drugs by plastic infusion tubing also shows a constant rate over a limited period and have described an equation relating the steady-state effluent concentrations of those drugs sorbed by tubing (in the period in which the plastic acts as a semi-infinite sink) to the infusion conditions. Thermodynamics of Sorption-The plastic-water partition coeffi-…”

Section: (A) (B) Rate Constants For the Evaporation Of I Across The mentioning

confidence: 99%

“…2) is the result of the plasticization process (8,9). Plasticizer molecules insert themselves between the polymer chains, reducing the intermolecular forces between the polymer chains and generating additional free volume (22)(23)(24)(25)(26).…”

Section: -=-mentioning

confidence: 99%

“…The loss was attributed to sorption and possibly permeation of the drug through the plastic components of the intravenous delivery systems (8,9). Tsuei and coworkers (10) have also reported sorption of I by plastic infusion sets and have suggested that I is lost from the infusion set to the atmosphere.…”

mentioning

confidence: 99%

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Dynamics of Clomethiazole Edisylate Interaction with Plastic Infusion Systems

Kowaluk

Roberts

Polack

1984

Journal of Pharmaceutical Sciences

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Section: Resultssupporting

confidence: 91%

Section: (A) (B) Rate Constants For the Evaporation Of I Across The mentioning

confidence: 99%

Section: (A) (B) Rate Constants For the Evaporation Of I Across The mentioning

confidence: 99%

Section: -=-mentioning

confidence: 99%

mentioning

confidence: 99%

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Dynamics of Clomethiazole Edisylate Interaction with Plastic Infusion Systems

Kowaluk

Roberts

Polack

1984

Journal of Pharmaceutical Sciences

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Hybrid sol gel coating: A solution to prevent interactions between plasticized poly(vinyl chloride) and injectable drugs?

Bernard

Cueff

Massard

et al. 2013

J of Applied Polymer Sci

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During the infusion of drugs with medical devices in plasticized poly(vinyl chloride) (PVC) release of plasticizers in the injectable solution and/or sorption of drugs on PVC may occur. Thus, patient safety and/or effectiveness of his therapy may be altered. In this study, we assessed the efficiency of a sol gel hybrid coating in preventing plasticizers' release (di-(2-ethylhexyl) phthalate (DEHP)) from PVC matrix and drug sorption into PVC. Remaining concentrations of drugs and plasticizer's concentration released after migration tests were assessed by liquid chromatography. Migration processes were followed by Fourier Transform Infrared -Attenuated Total Reflectance (FTIR-ATR) spectroscopy and PVC surface changes were characterized by scanning electron microscopy (SEM). An evaluation of the mechanical properties of both uncoated and coated polymer was done. The hybrid coating protects PVC from plasticizers leaching. Sorption of drugs tested is also limited. However, the protection against plasticized PVC interactions isn't optimal, probably due to a degradation of the layer, as shown on SEM microphotographs. Furthermore improvements might provide an efficient barrier to advert risks impaired to PVC interactions, to provide patient care safety. V C 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40145.

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Modelling Drug Loss during Intravenous Infusion to Premature Neonates

Anh¹,

Norris

Charles

2006

Pharmacy Practice and Res

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Background: Our experience has suggested that not all the drug dose put into an IV infusion reached the bloodstream of neonates. Aim: To use sparse-data modelling to estimate how much of a continuously infused dose of caffeine, gentamicin, phenobarbitone and vancomycin was delivered. To use the results to develop a modified infusion protocol to minimise drug losses. Method: Various drug infusions were prepared in duplicate (test, control). The test set was delivered through an in vitro infusion system identical to that used in the neonatal intensive care nursery. Samples were collected after flushing the system twice with 1.5 mL of normal saline. Each experiment was replicated 4 times for each drug. Drug concentrations were measured by enzyme immunoassay. Recovery and variability during flushing was described as a function of the normal saline flushing volume using an asymptotic mono-exponential accumulation model. Results: 53% of phenobarbitone, 60% of caffeine, 92% of gentamicin, and 99% of vancomycin doses were recovered. There was considerable variability in the recovery of phenobarbitone. Conclusion: Current infusion protocols appear inadequate for delivery of drugs to neonates and may result in suboptimal therapy. It is recommended that the administration set be completely primed with the drug and any additional volume of normal saline required, then flushed with a further 2 mL of normal saline to obtain a minimum 90% recovery of these drugs.

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Interactions between drugs and intravenous delivery systems

Cited by 22 publications

References 0 publications

Dynamics of Clomethiazole Edisylate Interaction with Plastic Infusion Systems

Dynamics of Clomethiazole Edisylate Interaction with Plastic Infusion Systems

Hybrid sol gel coating: A solution to prevent interactions between plasticized poly(vinyl chloride) and injectable drugs?

Modelling Drug Loss during Intravenous Infusion to Premature Neonates

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