Interactions between dextran, fibrinogen and plasma membranes

Rampling, M.W.

doi:10.1016/0006-2952(76)90140-4

Cited by 14 publications

(2 citation statements)

References 17 publications

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“…Dextran has been previously reported to interact with the RBC membrane at larger concentration of dextran (>10 mg mL -1 ). [24][25][26] The homogeneous color and intensity of the liposomes, however, indicate that the molecules are homogenously distributed within the liposomes (within the resolution limit of the microscope).…”

Section: Liposome Characterization and Encapsulation Of Moleculesmentioning

confidence: 99%

Hybrid Erythrocyte Liposomes: Functionalized Red Blood Cell Membranes for Molecule Encapsulation

et al. 2020

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The modification of erythrocyte membrane properties provides a new tool towards improved drug delivery and biomedical applications. The fabrication of hybrid erythrocyte liposomes is presented by doping red blood cell membranes with synthetic lipid molecules of different classes (PC, PS, PG) and different degrees of saturation (14:0, 16:0–18:1). The respective solubility limits are determined, and material properties of the hybrid liposomes are studied by a combination of X‐ray diffraction, epi‐fluorescent microscopy, dynamic light scattering (DLS), Zeta potential, UV‐vis spectroscopy, and Molecular Dynamics (MD) simulations. Membrane thickness and lipid orientation can be tuned through the addition of phosphatidylcholine lipids. The hybrid membranes can be fluorescently labelled by incorporating Texas‐red DHPE, and their charge modified by incorporating phosphatidylserine and phosphatidylglycerol. By using fluorescein labeled dextran as an example, it is demonstrated that small molecules can be encapsulated into these hybrid liposomes.

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Section: Liposome Characterization and Encapsulation Of Moleculesmentioning

confidence: 99%

Hybrid Erythrocyte Liposomes: Functionalized Red Blood Cell Membranes for Molecule Encapsulation

et al. 2020

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“…Alexander, K. T. (Rampling, 1974(Rampling, ,1976 has shown that the ability of the polysaccharide dextran to precipitate fibrinogen from solution is due solely to steric exclusion (Ogston, 1958), increasing the effective concentration of fibrinogen. The present work examines the effect of dextran on the thrombin-induced conversion of fibrinogen into fibrin.…”

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confidence: 99%

Effect of Steric Exclusion by Dextran on the Conversion of Fibrinogen into Fibrin

Rampling

Lane²,

Kakkar

1976

Biochemical Society Transactions

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Inhibition of bovine factor viii‐induced guinea pig platelet aggregation by simple sugars and derivatives

Kuwahara

Malik

1977

American J Hematol

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Working with the hypothesis that the binding of carbohydrate groups is important in the induction of platelet aggregation by bovine factor VIII, we studied 36 different sugars and sugar derivatives for their ability t o inhibit the aggregation of guinea pig platelets. Concentrations that produced 5 0% inhibition of the aggregation response ranged from 232 mM (galactose) t o 12 mM (glucosamine and galactosamine).Using these values, we found that several factors affected the ability of sugar structures t o inhibit bovine factor VIII-induced aggregation of guinea pig platelets. In general, galactose and its derivatives were not as effective as glucose and its derivatives. Sugars possessing a-glycosidic linkages tended to be stronger inhibitors than those having &linkages. Polyols were better inhibitors than their corresponding aldoses. D-fucose (129 mM) was a weaker inhibitor than L-fucose (66 mM), but Dand L-arabinitol were not significantly different. N-acetylation of glucosamine reduced its ability t o inhibit aggregation. The number of free hydroxyl groups in a molecule did not appear t o be a significant determinant of its ability t o inhibit aggregation.The results support the hypothesis that a binding site for carbohydrate groups exists either on the platelet membrane or on the bovine factor VIII molecule. The binding of the carbohydrate t o this site is an important step in the induction of aggregation, and this binding site is relatively specific for the carbohydrate structures that it will accept.

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Interactions between dextran, fibrinogen and plasma membranes

Cited by 14 publications

References 17 publications

Hybrid Erythrocyte Liposomes: Functionalized Red Blood Cell Membranes for Molecule Encapsulation

Hybrid Erythrocyte Liposomes: Functionalized Red Blood Cell Membranes for Molecule Encapsulation

Effect of Steric Exclusion by Dextran on the Conversion of Fibrinogen into Fibrin

Inhibition of bovine factor viii‐induced guinea pig platelet aggregation by simple sugars and derivatives

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