Interactions between cadmium and zinc in the organism

Brzóska, Małgorzata M.; Moniuszko-Jakoniuk, J

doi:10.1016/s0278-6915(01)00048-5

Cited by 358 publications

(242 citation statements)

References 104 publications

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“…Zn is one of the most important nutritional factors influencing the metabolism and toxicity of Cd [18]. The protective effect of Zn in condition of Cd exposure in animals has been demonstrated for many years by our and others research groups [11,17,48].…”

Section: Discussionmentioning

confidence: 95%

“…In parallel, we could not measure detectable amount of Cd in fetal testis. In the absence of detectable Cd, the increased expression of HSP 90 may be explained, at least in part, by an indirect mechanism of Cd toxicity such as interference with placental transport of essential element like Zn to the fetus [18,28,29].…”

Section: Discussionmentioning

confidence: 99%

“…Our previous study [15] imply that the downregulation of ZnT as well as the overexpression of ZIP transporters in the mammary gland of lactating rat and in the intestine of their offspring, play a major role in Cd accumulation and Zn redistribution in tissues of suckling rats. Zn testicular depletion during lactation seems also to be due to its sequestration by Cd-induced hepatic metallothioneins (MTs) from the plasma in the organism of offspring rats, thereby increasing its concentration in the liver and kidneys and probably restricting Zn supply to other tissues [18]. Furthermore, the present study showed that Cd-exposure during pregnancy and lactation has important effects on male offspring growth by reducing the body weight and the cranio-caudal length at the end of lactation (PND 21).…”

Section: Discussionmentioning

confidence: 99%

“…In the small intestine, enhanced consumption of Zn may decrease Cd absorption from the digestive tract and its accumulation in the offspring rat's organism, and as a result, it may protect against the toxic effects of Cd [15]. In the liver, interaction between Cd and Zn to induce MTs which sequesters Cd had been suggested as the most likely mechanisms [18]. Pre-treatment with Zn leads to rapid immobilization of Cd ions in the liver (in the form bound to the Zn-induced MTs) resulting in fewer of the ions present in the bloodstream for transport into testes [49].…”

Section: Discussionmentioning

confidence: 99%

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Protective role of zinc against the toxicity induced by exposure to cadmium during gestation and lactation on testis development

Chemek

Mimouna

Boughammoura

et al. 2016

Reproductive Toxicology

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Highlights Effects of Cd and Zn on testicular development were assessed. Cd accumulation and Zn depletion in testis during lactation were noted. Cd-induced abnormal seminiferous tubules and a plasmatic testosterone decrease. Zn supply induced a significant protection against Cd toxicity. Cd toxicity observed in pups is mediated by disruption of maternal Zn metabolism. *Research Highlights AbstractTo assess the effects of exposure to Cd and Zn on rat testicular development, offspring, from mothers receiving either tap water, Cd, Zn or Cd+Zn during gestation and lactation periods, were observed on gestational day (GD) 20 and on postnatal days (PND) 12, 21 and 35. During gestation, Cd induced maternal hypozincemia and less transfer of Zn to the fetus. During lactation, progressive Cd accumulation and Zn depletion in testis at PND12 and PND21 werenoted. An increase of abnormal seminiferous tubules and a decrease in testis weight and plasmatic testosterone concentration were also observed at PND21 and PND35 respectively. Interestingly, Zn supply induced a significant protection against Cd toxicity. These results suggest that the toxic effects of Cd observed during development are mediated by the disruption of Zn metabolism, which is established in mothers during pregnancy causing Zn deficiency in fetuses and continues to become more pronounced during lactation.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Protective role of zinc against the toxicity induced by exposure to cadmium during gestation and lactation on testis development

Chemek

Mimouna

Boughammoura

et al. 2016

Reproductive Toxicology

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“…In addition, such an assessment should be performed because some essential elements (e.g., zinc and copper) may interact with cadmium. In fact, it is known that the intake of zinc exceeding normal nutritional requirements may decrease the toxicological potential of ingested cadmium (Brzóska and Moniuszko-Jakoniuk 2001). However, exposure to cadmium may impair zinc absorption and distribution in organs and tissues, particularly in conditions of nutritional deficiency (Lönnerdal 2000;Schrey et al 2000).…”

Section: Cadmium Lead and Chromium Exposure Assessments For Huntersmentioning

confidence: 99%

Cadmium, Lead, and Chromium in Large Game: A Local-Scale Exposure Assessment for Hunters Consuming Meat and Liver of Wild Boar

Danieli

Serrani

Primi

et al. 2012

Arch Environ Contam Toxicol

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Heavy metals are ubiquitous in soil, water, and air. Their entrance into the food chain is an important environmental issue that entails risks to humans. Several reports indicate that game meat can be an important source of heavy metals, particularly because of the increasing consumption of game meat, mainly by hunters. We performed an exposure assessment of hunters and members of their households, both adults and children, who consumed wild boar (WB) meat and offal. We estimated the amount of cadmium, lead, and chromium in the tissues of WB hunted in six areas within Viterbo Province (Italy) and gathered data on WB meat and offal consumption by conducting specific diet surveys in the same areas. The exposure to cadmium, lead, and chromium was simulated with specifically developed Monte Carlo simulation models. Cadmium and lead levels in WB liver and meat harvested in Viterbo Province (Italy) were similar to or lower than the values reported in other studies. However, some samples contained these metals at levels greater then the EU limits set for domestic animals. The chromium content of meat or liver cannot be evaluated against any regulatory limit, but our results suggest that the amounts of this metal found in WB products may reflect a moderate environmental load. Our survey of the hunter population confirmed that their consumption of WB meat and liver was greater than that of the general Italian population. This level of consumption was comparable with other European studies. Consumption of WB products contributes significantly to cadmium and lead exposure of both adults and children. More specifically, consumption of the WB liver contributed significantly to total cadmium and lead exposure of members of the households of WB hunters. As a general rule, liver consumption should be kept to a minimum, especially for children living in these hunter households. The exposure to chromium estimated for this population of hunters may be considered to be safe. However, a specific and complete assessment of chromium speciation in relevant dietary and environmental situations should be conducted.

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Evaluation of Toxicological Interactions for the Dose‐Response Assessment of Chemical Mixtures

Krishnan

Isukapalli

Boyd

2009

General, Applied and Systems Toxicology

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Dose‐response assessment for chemical mixtures involves the characterization of the relationship between administered dose (or more appropriately target tissue dose) and tissue response, in order to facilitate the determination of safe exposure levels for humans. When interactions among chemicals occur, the consideration of mechanisms would be necessary for the conduct of scientifically sound dose‐response assessment for mixtures. The present chapter focusses on the current approaches for evaluating toxicological interactions for the dose‐response assessment of chemical mixtures. The approaches described in this chapter include: (i) interaction matrix method, (ii) interaction weighting ratio method and (iii) physiologically based pharmacokinetic (PBPK) modelling. The unique use of PBPK models in predicting the change in tissue dose of mixture components as a function of dose, route, exposure scenario and mixture complexity is highlighted. Finally, the interaction‐based dose‐response analysis of chemical mixtures is described, along with illustrative examples.

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Interactions between cadmium and zinc in the organism

Cited by 358 publications

References 104 publications

Protective role of zinc against the toxicity induced by exposure to cadmium during gestation and lactation on testis development

Protective role of zinc against the toxicity induced by exposure to cadmium during gestation and lactation on testis development

Cadmium, Lead, and Chromium in Large Game: A Local-Scale Exposure Assessment for Hunters Consuming Meat and Liver of Wild Boar

Evaluation of Toxicological Interactions for the Dose‐Response Assessment of Chemical Mixtures

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