Interactions between angiotensin II and baclofen in shuttle-box and passive avoidance performance

Georgiev, Vasil; Yonkov, D; Kambourova, T

doi:10.1016/0143-4179(88)90047-9

Cited by 42 publications

(13 citation statements)

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“…Our results disagree with others, mainly from the groups of Braszko (Braszko and Wisniewski 1988;Braszko et al 1995Braszko et al , 1998Braszko 2002) and Georgiev (Georgiev et al 1988;Belcheva et al 2000), suggesting that AII has a facilitatory action on memory, but concur with many others that advocate just the opposite (Morgan and Routtenberg 1977;Köller et al 1979;Barnes et al 1989;DeNoble et al 1991;Lee et al 1995;Raghavendra et al 1998). The reasons for this discrepancy are not clear, but perhaps they are hidden behind the fact that many of those studies utilized multitrial learning paradigms and intracerebroventricular infusions and, therefore, could not easily discriminate between acquisition, consolidation and retrieval related events and were not able to rule out possible nonspecific behavioral and physiological effects.…”

Section: Discussioncontrasting

confidence: 81%

Angiotensin II blocks memory consolidation through an AT2 receptor-dependent mechanism

et al. 2004

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Section: Discussioncontrasting

confidence: 81%

Angiotensin II blocks memory consolidation through an AT2 receptor-dependent mechanism

et al. 2004

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“…18) Memory in laboratory animals in the passive avoidance model is improved not only after the administration of drugs such as haloperidol and baclofen but also after the administration of herbal medicines such as Yukmijihwang-tang derivatives and ESP-102. [19][20][21][22] In the present study, BR003 significantly increased the response latency of rats in the passive avoidance test by up to 2.5-fold compared with the response of control rats. BR003 includes many herbal medicines that have neural effects.…”

Section: Discussionmentioning

confidence: 80%

The Effects of BR003 on Memory and Cell Proliferation in the Dentate Gyrus of Rat Hippocampus

Park

Huh

et al. 2006

Biological & Pharmaceutical Bulletin

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, whereas long-term memory (LTM) lasts for hours, days, weeks, and even years.1) The hippocampus is crucial for learning and memory in humans and animals. The hippocampus converts short-term memories into long-term memories and plays a pivotal role in encoding, consolidating, and retrieving associations that are responsible for episodic memory.2,3) The hippocampus and the entorhinal cortex both participate in the formation and expression of memory in the one-trial step-down inhibitory avoidance task in rats. 4) In mammals, neurons are produced early in development; however, in the dentate gyrus (DG) of the hippocampal formation, granule cell neurons are produced throughout adulthood. 5,6) Neurogenesis in the DG is a multi-step process that originates within the subgranular zone of the hippocampus. 7)New neurons produced from precursor cells in the subgranular zone extend axonal projections and express several markers that are specific to neurons. 8,9) New neurons in the DG of the hippocampus were recently shown to be integrated functionally into appropriate neuronal circuits, and hippocampusmediated learning and memory may be related to the generation of new neurons in the adult DG. 10,11) Many herbal drugs used in traditional medicine in Asia are generally combined in the form of multi-herbal formulas to create novel therapeutic agents that are more effective than the administration of the individual herbs.12) BR003 is a new formula that has been prescribed recently to enhance memory. BR003 comprises twelve medicinal herbs: Acanthopanacis Senticosi Radix (Acanthopanax senticosus HARMS, Araliaceae); Schizandrae Fructus (Schisandra chinensis BAILL., Magnoliaceae); Ginkgo Folium (Ginkgo biloba L., Ginkgoaceae); Ginseng Radix (Panax ginseng MEYER, Araliaceae); Astragali Radix (Astragalus membranaceus BUNGE, Leguminosae); Atractylodis Rhizoma (Atractylodes macrocephala KOIDZ., Compositae); Poria (Poria cocos WOLF, Polyporaceae); Ziziphi Semen (Zizyphus jujuba MILL., Rhamnaceae); Longanae Arillus (Euphoria Longan STEUD., Sapindaceae); Angelicae Sinensis Radix (Angelica sinensis DIELS, Umbelliferae); Polygalae Radix (Polygala tenuifolia WILLD., Polygalaceae); and Glycyrrhizae Radix (Glycyrrhiza uralensis FISCH., Leguminosae).Even though many herbal remedies are used in traditional medicine to improve memory and cognitive function, whether herbal remedies enhance cell proliferation within the hippocampus is largely unknown.13) In this study, we investigated the effect of BR003 on learning and memory in rats and on cell proliferation in the DG of rat hippocampus. MATERIALS AND METHODS Plant Materials and Preparation of BR003Individual dried herbs were purchased from Wonkwang Herbal Drug Co. Ltd. (Seoul, Korea). BR003 comprised 14% each Acanthopanacis Senticosi Radix, Schizandrae Fructus, and Ginkgo Folium; 7% each Ginseng Radix, Astragali Radix, Atractylodes Rhizoma, Poria, Ziziphi Semen, Longanae Arillus, Angelicae Sinensis Radix, and Polygalae Radix; and 2% Glycyrrhizae Radix. BR003 extract was prepared by decocting 5...

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“…Similar to the inconsistent findings with regard to baclofen efficacy in anxiety tests, the effects of baclofen on learning and memory have also been variable, ranging from impairment (Castellano et al, 1989; McNamara and Skelton, 1996; Nakagawa and Takashima, 1997; Pitsikas et al, 2003; Stackman and Walsh, 1994; Zarrindast et al, 2004) to facilitation (Georgiev et al, 1988; Saha et al, 1993) in rodents. In contrast, a recent clinical study indicated that baclofen produced bi-directional effects on reinforcement learning (i.e., low doses facilitated and high dose did not affect learning in humans) (Terrier et al, 2011).…”

Section: Discussionmentioning

confidence: 92%

Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice

Risbrough

Cates-Gatto

et al. 2013

Neuropharmacology

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γ-Aminobutyric acid B (GABAB) receptor activation is a potential therapeutic approach for the treatment of drug addiction, pain, anxiety, and depression. However, full agonists of this receptor induce side-effects, such as sedation, muscle relaxation, tolerance, and cognitive disruption. Positive allosteric modulators (PAMs) of the GABAB receptor may have similar therapeutic effects as agonists with superior side-effect profiles. The present study behaviorally characterized N-([1R,2R,4S]-bicyclo[2.2.1]hept-2-yl)-2-methyl-5-(4-[trifluoromethyl]phenyl)-4-pyrimidinamine (BHF177), a GABAB receptor PAM, in mouse models of anxiety-like behavior, learning and memory. In addition, the effects of BHF177 were compared with the agonist baclofen. Unlike the anxiolytic chlordiazepoxide, baclofen (0.5, 1.5, and 2.5 mg/kg, intraperitoneally) and BHF177 (10, 20, and 40 mg/kg, orally) had no effect on anxiety-like behavior in the elevated plus maze, light/dark box, or the Vogel conflict test. Baclofen increased punished drinking in the Vogel conflict test, however this effect may be attributable to analgesic actions of baclofen. At the highest dose tested (2.5 mg/kg), baclofen-treated mice exhibited sedation-like effects (i.e., reduced locomotor activity) across many of the tests, whereas BHF177-treated mice exhibited no sedation-like effects. BHF177 exhibited pro-convulsion properties only in mice, but not in rats, indicating that this effect may be species-specific. At doses that were not sedative or pro-convulsant, baclofen and BHF177 had no selective effects on fear memory retrieval in contextual and cued fear conditioning or spatial learning and memory in the Barnes maze. These data suggest that BHF177 has little sedative activity, no anxiolytic-like profile, and minimal impairment of learning and memory in mice.

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Interactions between angiotensin II and baclofen in shuttle-box and passive avoidance performance

Cited by 42 publications

References 4 publications

Angiotensin II blocks memory consolidation through an AT2 receptor-dependent mechanism

Angiotensin II blocks memory consolidation through an AT2 receptor-dependent mechanism

The Effects of BR003 on Memory and Cell Proliferation in the Dentate Gyrus of Rat Hippocampus

Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice

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