Interactions between ambient air pollution and obesity on lung function in children: The Seven Northeastern Chinese Cities (SNEC) Study

Xing, Xiumei; Hu, Liwen; Guo, Yuming; Bloom, Michael S.; Li, Shanshan; Chen, Gongbo; Yim, Steve Hung Lam; Gurram, Namratha; Yang, Mo; Xiao, Xiang; Xu, Shaoyuan; Wei, Qi; Yu, Hongyao; Yang, Bo‐Yi; Zeng, Xiao‐Wen; Chen, Wen; Hu, Qiang

doi:10.1016/j.scitotenv.2019.134397

Cited by 46 publications

(40 citation statements)

References 89 publications

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“…Most previous studies have suggested an inverse relationship between obesity and changes in lung function [ 13 , 16 ]. However, it is essential to note that most studies have only compared lung function in overweight or obese people with average weight [ 14 , 16 , 20 ], ignoring the possible effects of low body fat on lung function. Of course, we know that obesity is a severe problem in the world today.…”

Section: Discussionmentioning

confidence: 99%

Nonlinear relationship between visceral adiposity index and lung function: a population-based study

Wang

2021

Respir Res

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Background As one of the critical indicators of obesity, the interaction between visceral fat content and lung disease is the focus of current research. However, the exact relationship between Visceral adipose index (VAI) and lung function is not fully understood. The purpose of this study was to evaluate the relationship between VAI and lung function, Methods Our study included all participants from the baseline survey population in Xinjiang in the Natural Population Cohort Study in Northwest China. A field survey was conducted in rural areas of Moyu County, Xinjiang, China, between 35 and 74 years old from June to December 2018. We collected standard questionnaires and completed physical examinations, visceral fat tests, and lung function measurements. Results The study included 2367 participants with a mean VAI of 10.35 ± 4.35, with males having a significantly higher VAI than females: 13.17 ± 3.91 vs. 7.58 ± 2.65. The piecewise linear spline models indicated a significant threshold effect between lung function and VAI in the general population and the males population, showing an inverted U-shaped curve. But there was no significant association between VAI and lung function in females. FEV1% predicted and FVC% predicted increased with the increase of VAI (β 0.76; 95% CI 0.30, 1.21) and (β 0.50; 95% CI 0.06, 0.94) in males with VAI ≤ 14, while FEV1% predicted and FVC% predicted decreased with the increase of VAI (β − 1.17; 95% CI − 1.90, − 0.45) and (β − 1.36; 95% CI − 2.08, − 0.64) in males with VAI ≥ 15. Conclusions The relationship between lung function and VAI in male participants showed an inverted U-shaped curve, with the turning point of VAI between 14 and 15. The association between visceral fat and lung function was more robust in males than in females.

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Section: Discussionmentioning

confidence: 99%

Nonlinear relationship between visceral adiposity index and lung function: a population-based study

Wang

2021

Respir Res

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“…64 Obesity is associated with increased wheezing and a decline in lung function in those exposed to PM. 65 In patients with pre-existing respiratory diseases such as asthma or chronic obstructive pulmonary disease (COPD), obesity is associated with increases in the frequency or severity of symptoms, such as dyspnea. 66,67 This enhanced vulnerability as a result of excess weight is likely due in part to the innate hyperresponsiveness of the airway in obesity.…”

Section: Pulmonary Effects Associated With Mets and Pm Exposuresmentioning

confidence: 99%

Particulate matter inhalation and the exacerbation of cardiopulmonary toxicity due to metabolic disease

Kobos

Shannahan

2021

Exp Biol Med (Maywood)

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Particulate matter is a significant public health issue in the United States and globally. Inhalation of particulate matter is associated with a number of systemic and organ-specific adverse health outcomes, with the pulmonary and cardiovascular systems being particularly vulnerable. Certain subpopulations are well-recognized as being more susceptible to inhalation exposures, such as the elderly and those with pre-existing respiratory disease. Metabolic syndrome is becoming increasingly prevalent in our society and has known adverse effects on the heart, lungs, and vascular systems. The limited evaluations of individuals with metabolic syndrome have demonstrated that they may compose a sensitive subpopulation to particulate exposures. However, the toxicological mechanisms responsible for this increased vulnerability are not fully understood. This review evaluates the currently available literature regarding how the response of an individual’s pulmonary and cardiovascular systems is influenced by metabolic syndrome and metabolic syndrome-associated conditions such as hypertension, dyslipidemia, and diabetes. Further, we will discuss potential therapeutic agents and targets for the alleviation and treatment of particulate-matter induced metabolic illness. The information reviewed here may contribute to the understanding of metabolic illness as a risk factor for particulate matter exposure and further the development of therapeutic approaches to treat vulnerable subpopulations, such as those with metabolic diseases.

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“…Calculating participants' age retrospectively for each period, for instance, 29 years old participants were 18 and 22 years old in 2006 and 2010 respectively. Using the same backward calculation, median aged group; 24 years old and least aged group, 19 years old in the year 2017 were (13,17) and (8,12) in 2006 and 2010 respectively. Applying that calculation, this study subjects' age are ranged from 2 to 12 years old.…”

Section: Associations Between Obesity and Environmental Factorsmentioning

confidence: 99%

“…As one of environmental factor related with obesity, particulate matters (PM) were investigated for various comorbidity conditions [4][5][6] , age-groups [7][8][9][10] , gender [4] , regions [11] , and socioeconomic status such as education level [12,13], household income [13][14][15][16][17][18], or occupational characteristics [12]. They are mostly based on cohort study to figure out long-term effect of PM.…”

Section: Introductionmentioning

confidence: 99%

Municipal Residence Level of Long-Term PM10 Exposure Associated with Obesity among Young Adults in Seoul, Korea

Kim

Yoon

2020

Preprint

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Background: The associations between long-term exposure to particulate matters (PM) in residential ambiance and obesity are comparatively less elucidated among young adults. Methods: Using 2017 Community Health Survey data with aged 19−29 participants in 25 communities, Seoul, the relationship between obesity and long−term PM10 levels of living district was examined. We defined obesity as overweight (25≤BMI&lt;30) or obese (30≤BMI) using Body Mass Index (BMI) from self-reported anthropometric information. Analysis was conducted sampling weighted logistic regression models by fitting municipal PM10 levels according to individual residence periods with 10 years and more residing in a current municipality. Socio-demographic factors were adjusted over all models and age−specific effect was explored among aged 19–24 and 25–29. Results: Total study population are 3,655 [men 1,680 (46.0%) and aged 19–24 1,933 (52.9%)] individuals. Among the communities with greater level of PM10; 2001–2005, associations with obesity were increased for overall with residence period; 10 years ≤ [Odds ratio, OR 1.071, 95% Confidence interval (CI) 0.969–1.185], 15 years ≤ [OR 1.118, 95% CI 1.004–1.245], and 20 years ≤ [OR 1.156, 95% CI 1.032–1.294]. However, decreased associations were detected for PM10; 2006–2010, and age–specific effects were modified according to the residence period. Conclusions: Although currently PM10 levels are decreasing, higher levels of PM10 exposure at the residential area during the earlier life-time may contribute in increasing obesity among young adults.

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Interactions between ambient air pollution and obesity on lung function in children: The Seven Northeastern Chinese Cities (SNEC) Study

Cited by 46 publications

References 89 publications

Nonlinear relationship between visceral adiposity index and lung function: a population-based study

Nonlinear relationship between visceral adiposity index and lung function: a population-based study

Particulate matter inhalation and the exacerbation of cardiopulmonary toxicity due to metabolic disease

Municipal Residence Level of Long-Term PM10 Exposure Associated with Obesity among Young Adults in Seoul, Korea

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