Interactions and Conformational Fluctuations in Macromolecular Arrays

Podgornik, Rudolf

doi:10.1007/978-94-010-0577-7_12

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Osmotic Pressure: Ssrna Viruses Vs Dsdna Bacteriophages1

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2012

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“…While in the case of the dsDNA bacteriophages the electrostatic interaction energy stems largely from the interactions acting between the segments of nucleic acid component within the volume of the virus 201 , in the case of the ssRNA viruses the most important contribution comes from the interaction between the ssRNA genome and the hypotopic surface of the capsid. This contrast in the interaction mechanisms shows up eventually as the R −6 scaling for DNA viruses vs. the R −5 scaling for the ssRNA viruses in the simple picture introduced above.…”

Section: Osmotic Pressure: Ssrna Viruses Vs Dsdna Bacteriophagesmentioning

confidence: 99%

Energies and pressures in viruses: contribution of nonspecific electrostatic interactions

Šiber

Božič

Podgornik

2012

Phys. Chem. Chem. Phys.

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130

153

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We summarize some aspects of electrostatic interactions in the context of viruses. A simplified but, within well defined limitations, reliable approach is used to derive expressions for electrostatic energies and the corresponding osmotic pressures in single-stranded RNA viruses and double-stranded DNA bacteriophages. The two types of viruses differ crucially in the spatial distribution of their genome charge which leads to essential differences in their free energies, depending on the capsid size and total charge in a quite different fashion. Differences in the free energies are trailed by the corresponding characteristics and variations in the osmotic pressure between the inside of the virus and the external bathing solution.

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Section: Osmotic Pressure: Ssrna Viruses Vs Dsdna Bacteriophagesmentioning

confidence: 99%