Interaction with bioligands and in vitro cytotoxicity of a new dinuclear dioxido vanadium(V) complex

Polyoxidovanadates [MoVIVV9O28]5- and [H2PtIVVV9O28]5- interact with CHO cell plasma membrane lipids causing aggregation and activation of a G protein-coupled receptor

“…Vanadium coordination complexes have been the focus of recent work in cell systems (Scalese et al, 2019;Treviño and Diaz, 2020;Loizou et al, 2021, He et al, 2020Biswas et al, 2022;Ferretti and León, 2022;Ribeiro et al, 2022;Semiz, 2022;Althumairy et al, 2020a;Sahu et al, 2022). Our group has shown that bismaltolatodioxovanadium(IV) (BMOV) and polyoxidovanadates are able to initiate signaling by the luteinizing hormone receptor (LHR), a G-protein coupled receptor (GPCR) (Roess et al, 2008;Crans et al, 2011;Winter et al, 2012;Al-Quatati et al, 2013;Althumairy et al, 2020b;Althumairy et al, 2020c;Althumairy et al, 2020d;Samart et al, 2020).…”

Complexation behavior of copper and zinc divalent ions towards diisatin malonyl dihydrazone ligand with biological and catalytic assessments

“…The antibacterial reactivity of new constructed mononuclear vanadium (III) complexes of hydrazide‐hydrazone ligands was studied in detail with comparable theoretical essays, which were published by Meenatchi et al 13 Azo‐methine and imine chelates of VO 2+ , Zn 2+ , and Cu 2+ have been employed against DNA for the evaluation of their interacting ability, which represented currently referring to the nature of such interacting binding 14 . The role of the coordinate hydrazone chelates, as bio‐organoligands, was discovered in vitro cytotoxicity examination for the dinuclear complexes of dioxo‐vanadium (V) ions, which was reported at present by Choudhury et al 15 The biological importance of such hydrazone ligands in their coordinated forms and their relationship with vanadium and molybdenum ions, as pyridoxal derivatives, was examined and documented by Avecilla et al 16 …”

“…12 The antibacterial reactivity of new constructed mononuclear vanadium (III) complexes of hydrazide-hydrazone ligands was studied in detail with comparable theoretical essays, which were published by Meenatchi et al 13 Azomethine and imine chelates of VO 2+ , Zn 2+ , and Cu 2+ have been employed against DNA for the evaluation of their interacting ability, which represented currently referring to the nature of such interacting binding. 14 The role of the coordinate hydrazone chelates, as bioorganoligands, was discovered in vitro cytotoxicity examination for the dinuclear complexes of dioxo-vanadium (V) ions, which was reported at present by Choudhury et al 15 The biological importance of such hydrazone ligands in their coordinated forms and their relationship with vanadium and molybdenum ions, as pyridoxal derivatives, was examined and documented by Avecilla et al 16 The most versatile transition metals are copper and zinc (the most abundant and cheap ones in the earth's crust) with structural and chemical interests for various bio-applicable purposes. 17 At present, alternate substituted derivatives of hydrazones as chelating ligands in their complexes have been built up to explore their amazing biological power, for example, Sadasivan et al reported the synthetic strategy for Cu 2+ , Ni 2+ , and Fe 3+ complexes derived from dioxanylidene-hydrazinyl-benzoic acid ligand.…”

Catalytic, Antifungal, and Antiproliferative Activity Studies of a New Family of Mononuclear [VIVO]/[VVO2] Complexes

“…In vitro and in vivo models have also suggested that vanadium complexes exhibit reduced side effects and better anticancer activity toward human cancer cell lines. , Some vanadium complexes also appear to be even more promising than cis -platin . Recently, studies on vanadium complexes with hydrazide-based ligands have shown very promising antimicrobial and antitumor activities, while hydrazine-based vanadium complexes have not been explored in this context. Both fungi and cancerous cells are eukaryotic; however, many differences are there, i.e., the cell wall of fungi and the cell membrane of animal cells are made up of different components.…”

“…Further, it has been found that oxidovanadium­(IV), oxidovanadium­(V), and dioxidovanadium­(V) complexes show immense potential with a wide range of biological applications and have been shown to have antiamoebic, antiparasitic, antifungal, antiproliferative, , and antidiabetic activities. In vitro and in vivo models have also suggested that vanadium complexes exhibit reduced side effects and better anticancer activity toward human cancer cell lines. , Some vanadium complexes also appear to be even more promising than cis -platin . Recently, studies on vanadium complexes with hydrazide-based ligands have shown very promising antimicrobial and antitumor activities, while hydrazine-based vanadium complexes have not been explored in this context.…”