Interaction studies of lead(II) ion with cyclic β‐(1→3),(1→6) glucans extracted from <i>Bradyrhizobium japonicum</i> based on ‘chelation enhanced fluorescence’ (CHEF) effect

Visweswar, K. N. S.; Sunil, A.; Harsha, A. Sri; Janardhana, Ch.

doi:10.1002/bio.3536

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…In addition to the mushroom having antioxidants, it has important amounts of beta glucan, a soluble fiber that is directly related to the Pb metabolism. According to Visweswar et al (2008) [ 54 ], three cyclic beta glucans interact with Pb, chelating it and, thus, reducing its toxic effects.…”

Section: Discussionmentioning

confidence: 99%

Influence of Agaricus bisporus Mushroom on Pb Toxicokinetic in Pregnant Rats

Caetano

Pedron

Freire

et al. 2023

IJERPH

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(Pb) is a toxic metal, responsible for several damages to human health. Agaricus bisporus (Ab) is a mushroom with promising antioxidant properties to be used as an alternative chelator in Pb intoxication. The aim was to understand the Pb toxicokinetic and the potential of Ab as a protective agent. A total of 20 female Wistar rats were distributed into 4 groups (n = 5/group): Control (receiving water); Group Ab 100 mg/kg (gavage); Group Pb 100 mg/L in water; and Group Ab + Pb—100 mg/kg + 100 mg/L (gavage and water). Pb administration occurred daily until the 19th day of pregnancy. On day 19 of gestation, the rats were euthanized, and the blood and tissues were collected for Pb measurement, using an inductively coupled plasma mass spectrometer. The results showed that the levels of Pb in the blood, placenta, and liver of the mothers, and in the brain of the fetuses increased significantly in the Pb group. On the other hand, the combined exposure to Pb + Ab showed a significant decrease in the metal concentration in relation to the Pb group, returning to normal levels. Kidney and bone lead levels also increased significantly in the Pb group. However, in the combined exposure group, levels did not return to the control amounts; there was protection, but the Pb concentration was still significantly higher than in the control. In the brain, no significant differences were observed. In conclusion, we suggest A. bisporus is a natural chelator, because the co-administration of the mushroom was able to interact with Pb ions, minimizing the Pb absorption and distribution. These effects are suggested since A. bisporus have antioxidants and beta glucan that interact with Pb, chelating it and, thus, reducing its toxic effects.

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Section: Discussionmentioning

confidence: 99%

Influence of Agaricus bisporus Mushroom on Pb Toxicokinetic in Pregnant Rats

Caetano

Pedron

Freire

et al. 2023

IJERPH

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“…Regarding the bone alterations found in fetuses exposed to mushroom, we hypothesize these changes may have been caused by a deficiency of some nutrient. Since mushrooms can chelate toxic metals because they have compounds able to bind to chemical elements, such as chitin and chitosan (Visweswar et al, 2018), These compounds have the potential to bind with essential minerals, such as calcium, magnesium, manganese, and iron, all of which are bivalent cations. A similar finding was reported with the mushroom L. edodes , which was responsible to decreased levels of copper, iron, manganese, and cobalt in the liver of healthy male rats (Grotto et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Considering mushrooms, according to Visweswar et al (2018) three cyclic beta glucans from Bradyrhizobium japonicum can interact with Pb by chelating it. Additionally, edible mushrooms residues demonstrated adsorb lead and copper from contaminated water, probably due to the chitin and chitosan contents in mushroom (Castanho et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Agaricus bisporus mushroom against maternal and fetal damage induced by lead administration during pregnancy in rats

Caetano,

Frattes,

Segato

et al. 2023

Birth Defects Research

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IntroductionLead (Pb) is a toxic pollutant, which can affect different tissues of the human body. The use of natural elements, as medicinal mushroom can reduce the toxic effects of Pb.ObjectiveWe evaluated, through preclinical tests, the oral co exposures to mushroom Agaricus bisporus (Ab) by gavage and Pb in drinking water, and the capability of Ab be a protective agent for both pregnant rats and their fetuses.MethodsFemale Wistar rats were divided into four groups (n = 5/group): Group I—Control; Group II—Ab 100 mg/kg; Group III—Pb 100 mg/L; Group IV—Ab +Pb −100 mg/kg +100 mg/L. Exposure was performed until the 19th day of gestation. On the 20th day, pregnant rats were euthanized, and the outcomes evaluated were weight gain; hematological profile; biochemical markers; oxidative stress markers; reproductive capacity; and embryo fetal development.ResultsThe characterization of mushrooms reveals them to be a valuable source of nutrients. However, Pb ingestion resulted in reduced weight gain and negative impacts on hematological and biochemical parameters. Fortunately, co administration of mushrooms helped to mitigate these negative effects and promote recovery. The mushroom also showed antioxidant activity, improving parameters of oxidative stress. In addition, Ab partially recovered the damage in fetal morphology and bone parameters.ConclusionOur findings indicated that the co administration of Ab improved the toxicity caused by Pb, and the mushroom could be used as a natural alternative as a protective/chelator agent.

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Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2017–2018

Harvey

2021

Mass Spectrometry Reviews

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This review is the tenth update of the original article published in 1999 on the application of matrix‐assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2018. Also included are papers that describe methods appropriate to glycan and glycoprotein analysis by MALDI, such as sample preparation techniques, even though the ionization method is not MALDI. Topics covered in the first part of the review include general aspects such as theory of the MALDI process, new methods, matrices, derivatization, MALDI imaging, fragmentation and the use of arrays. The second part of the review is devoted to applications to various structural types such as oligo‐ and poly‐saccharides, glycoproteins, glycolipids, glycosides, and biopharmaceuticals. Most of the applications are presented in tabular form. The third part of the review covers medical and industrial applications of the technique, studies of enzyme reactions, and applications to chemical synthesis. The reported work shows increasing use of combined new techniques such as ion mobility and highlights the impact that MALDI imaging is having across a range of diciplines. MALDI is still an ideal technique for carbohydrate analysis and advancements in the technique and the range of applications continue steady progress.

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Interaction studies of lead(II) ion with cyclic β‐(1→3),(1→6) glucans extracted from Bradyrhizobium japonicum based on ‘chelation enhanced fluorescence’ (CHEF) effect

Cited by 4 publications

References 20 publications

Influence of Agaricus bisporus Mushroom on Pb Toxicokinetic in Pregnant Rats

Influence of Agaricus bisporus Mushroom on Pb Toxicokinetic in Pregnant Rats

Protective effect of Agaricus bisporus mushroom against maternal and fetal damage induced by lead administration during pregnancy in rats

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2017–2018

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