Interaction of Vitamins A and E

Davies, A. W.; Moore, Thomas

doi:10.1038/147794a0

Cited by 93 publications

(18 citation statements)

References 9 publications

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“…It is concluded that dietary antioxidants used here had no significant effect on the prevention of reduction of hepatic vitamin A caused by PCB. It was found that liver storage of vitamin A increased in vitamin E-and DPPDtreated rats (26,27), although neither of these reports distinguished protective effects in the diet from those occurring in vivo. In contrast to these reports, Green et al (28) presented the case that under conditions ruling out interaction in the diet, vitamin E had no effect on the rate of depletion of vitamin A from the liver.…”

Section: Resultsmentioning

confidence: 93%

Influence of dietary antioxidants on polychlorinated biphenyls (PCB)-induced hepatic lipid peroxide formation and vitamin A reduction in rats.

Saito

Ikegami

Ito

et al. 1982

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThis paper describes experiments designed to characterize the effect of dietary antioxidants on lipid peroxide formation and vitamin A reduction in the liver of rats fed on diets containing polychlorinated biphenyls (PCB). Rats were given 0.025% PCB diets supplemented with dietary antioxidants, for 2 weeks. The antioxidants used were as follows: 10mg% (basal and usual level), 50mg% and 100mg% of vitamin E, and 50mg% of DPPD and tinoridine respectively. A marked liver enlargement and a significant increase of total liver lipid content were observed in the PCB-fed groups irrespective of the levels of vitamin E and kinds of antioxidants, suggesting that antioxidants were ineffective in preventing the development of fatty liver. Endogeneous lipid peroxide contents in the liver of rats receiving the diets containing 10mg% vitamin E, DPPD, and tinoridine with PCB increased significantly, whereas no increase was found with the 50 and 100mg% vitamin E diets with PCB. Hepatic glutathione peroxidase activity was unaffected by PCB and dietary antioxidants. No increase in hepatic vitamin E content occurred in the PCB groups with the addition of 10mg% vitamin E, DPPD, and tinoridine. However, dietary supplementation of vitamin E at higher levels caused an elevation of hepatic vitamin E content and a further increase was observed on the addition of PCB. These results suggest that a sufficiently high level of vitamin E suppresses the increment of the endogeneous lipid peroxide content in the liver of rats fed PCB. On the other hand, the administration of PCB to rats resulted in a significant decrease in hepatic vitamin A content regardless of the levels of 1 Polychlorinated biphenyls toxicity and nutrition . XIV. Polychlorinated biphenyls toxicity and vitamin A (7).

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Section: Resultsmentioning

confidence: 93%

Influence of dietary antioxidants on polychlorinated biphenyls (PCB)-induced hepatic lipid peroxide formation and vitamin A reduction in rats.

Saito

Ikegami

Ito

et al. 1982

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…In young animals the presence of dental depigmentation is sometimes difficult to assess, but as time progressed it became apparent that the development and the final appearance of this depigmentation differed in no way from that known to occur in rats fed on a diet deficient in tocopherol and prevented by it (Davies & Moore, 1941). Of interest, for the purpose of the present paper, is the fact that, in all animals given the supplement of selenium, depigmentation of the upper incisors in time became complete, and once established remained so.…”

Section: Resultsmentioning

confidence: 99%

Selenium, liver necrosis and depigmentation of incisors in the rat

Aterman¹

1959

Br J Nutr

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“…Cod-liver oil may also precipitate the symptoms of vitamin E deficiency in calves (Blaxter, Watts & Wood, Vitamin E also protects vitamin A, both in the tissues (Davies & Moore, 1941) and in the intestinal tract (Hickman, Harris & Woodside, 1942). The utilization of carotene is increased by small doses of tocopherol, but decreased by massive doses.…”

Section: Vitamin Ementioning

confidence: 99%