Interaction of vasopressin with the nigro-striatal dopamine system: Site and mechanism of action

Heuven-Nolsen, D. van; Versteeg, Dirk H.G.

doi:10.1016/0006-8993(85)90063-0

Cited by 24 publications

(8 citation statements)

References 29 publications

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“…Therefore, the biological effects of IRAP inhibitors like Ang IV may be the consequence of the inhibition of the cleavage by IRAP of one or more of these bioactive peptides. Indeed, previous in vivo microdialysis studies have shown that vasopressin (Van Heuven‐Nolsen and Versteeg 1985) and somatostatin (Thermos et al . 1996) are able to increase striatal DA release in rats.…”

Section: Discussionmentioning

confidence: 99%

Metabolism of angiotensin II is required for its in vivo effect on dopamine release in the striatum of the rat

Stragier¹,

Sarre²,

Vanderheyden

et al. 2004

Journal of Neurochemistry

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The effect of angiotensin (Ang) IV, an inhibitor of insulinregulated aminopeptidase (IRAP), on extracellular dopamine levels in the striatum of freely moving rats was examined using in vivo microdialysis. The Ang IV was administered locally in the striatum through the microdialysis probe. A concentration-dependent (10-100 lM) increase in extracellular striatal dopamine was observed. The effect of Ang II (10-100 lM), which has only a weak affinity for IRAP, was similar to that observed for Ang IV. The effects of both peptides could not be blocked by the AT 1 antagonist candesartan (10 nM and 1 lM) nor by the AT 2 antagonist S-(+)-1-([4-(dimethylamino)-3-methylphenyl]methyl)-5-(diphenyl-acetyl)-4,5,6,7-tetrahydro-1H-amidazo(4,5-c) pyridine-6-carboxylic acid (1 lM), suggesting that the observed effects are both AT 1 and AT 2 independent. The effect of Ang II could be blocked by the aminopeptidase-A inhibitor (S)-3-amino-4-mercaptobutylsulphonic acid as well as the aminopeptidase-N inhibitor 2-amino-4-methylsulphonylbutane thiol, indicating that the effect of Ang II is mediated via metabolism into Ang IV. Other IRAP inhibitors, such as Divalinal-Ang IV and LVV-haemorphin-7, had similar effects on extracellular dopamine levels as compared with Ang IV. We propose a role for IRAP as mediator for the effects of Ang IV and related peptides on extracellular dopamine levels in the striatum of the rat.

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Section: Discussionmentioning

confidence: 99%

Metabolism of angiotensin II is required for its in vivo effect on dopamine release in the striatum of the rat

Stragier¹,

Sarre²,

Vanderheyden

et al. 2004

Journal of Neurochemistry

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“…These are related to mem ory processes [Wimersma Greidanus et al, 1983;de Wied et al, 1984;Dantzer et al, 1988], passive avoid ance behavior [de Wied et al, 1984;Soderstcn et al, 1985Soderstcn et al, , 1986Veldhuis et al, 1987], thermoregulation [Kasting et al, 1982;Cooper et al, 1987;Pittman et al, 1988;Kasting, 1989] and blood pressure [Pittman et al, 1982;Sodersten et al, 1983]. Furthermore, several studies have indicated that there are strong in teractions between catecholamines and vasopressin [Kovacs et al, 1977[Kovacs et al, , 1979ade Wied and Bohus, 1978;Marchand and Hagino, 1982;Buijs et al, 1984;van Heuven-Nolsen and Versteeg, 1985;Nakada and Nakai, 1985]. Based on the strong resemblance of the distribution of extrahypothalamic VTi fibers in rep tiles and mammals, particularly the innervation of limbic structures, the midbrain dopaminergic cell groups and the nucleus of the solitary tract, it is con ceivable that reptilian vasotocinergic systems also play a role in memory and in behavioral and auto nomic functions.…”

Section: Functional Considerationsmentioning

confidence: 99%

Comparative Analysis of Vasotocin-Like Immunoreactivity in the Brain of the Turtle Pseudemys scripta elegan s and the Snake Python regius (Part 2 of 2)

Smeets¹,

Sevensma²,

Jonker³

1990

Brain Behav Evol

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The distribution of vasotocin in the brains of the turtle Pseudemys scripta elegans and the snake Python regius was studied with immunohistochemical methods. In both species, vasotocin-immunoreactive (VTi) cells were found in the supraoptic nucleus, the paraventricular nucleus and the bed nucleus of the stria terminalis. No VTi cell bodies were seen in the brainstem. Vasotocinergic fibers were found in all major brain divisions. Intrahypothalamic VTi fibers were observed between the supraoptic and the paraventricular nuclei and in the median eminence? An extensive network of extrahypothalamic VTi fibers extends from the olfactory bulb to the spinal cord. Limbic structures, such as the nucleus accumbens, the septal area and the ventral amygdaloid nucQsus, contain a moderate to dense VTi plexus. Other areas with a substantial number of VTi fibers are the lateral habenular nucleus, the ventral tegmental area, the substantia nigra, the locus coeruleus and the nucleus of the solrmxy tract. Sex-related differences in the density of the VTi fibers were observed in the lateral septal nucleus, the midbrain periaqueductal gray and, to a lesser extent, in the ventral amygdaloid nucleus, the lateral habenular nucleus, the ventral tegmental area and the substantia nigra. In these areas, the density of VTi fibers is higher in males than in females. The distribution of vasotocin-like immunoreactivity in the brains of Pseudemys and Python resembles the pattern previously observed in the lizard Gekko gecko. However, among the three species several differences exist, the most remarkable one being the variation in number of liquor-contacting VTi cells in the paraventricular nucleus.

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“…1979) and these structures as well as central dopaminergic mechanisms are implicated in the modulation of cardiovascular function and body fluid homeostasis (Kawabe et a/. 1983;Van Heuven-Nolsen & Versteeg 1985). However, little information is currently available on the renal effects of NT.…”

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confidence: 99%

Antidiuretic Effects of Neurotensin in Chloralose Anaesthetized Dogs

Kivlighn

Jandhyala

1990

Clin Exp Pharma Physio

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1. Effects of cerebroventricular and/or intravenous infusions of neurotensin (NT), an endogenous tridecapeptide, on haemodynamics and renal function were investigated in chloralose anaesthetized dogs. 2. Cerebroventricular infusions (i.c.v.) of NT (10-6 mol/L and 10-5 mol/L, 0.1 mL/min) for 30 min did not produce any significant alterations in the measured variables. In the vagotomized dogs, intravenous (i.v.) infusion of NT (10(-5) mol/L) at a rate of 0.1 mL/min for 30 min significantly lowered the arterial blood pressure and glomerular filtration rate; these effects were accompanied by pronounced reductions in the urine flow and urinary sodium excretion and marked increases in urine osmolality. 3. In the dogs with vagi intact, i.v. infusions of NT failed to produce any alterations in the blood pressure; however, renal effects of NT were essentially identical to those observed in the vagotomized dogs. 4. Infusions of NT (10(-6) mol/L) and/or NT-metabolites NT1-8 and NT8-13 (10(-5) mol/L) directly into the renal artery failed to produce any significant alterations in the urine flow. Antidiuretic effects of i.v. NT were not prevented by acute renal denervation, adrenalectomy, or pretreatment of the animals with naloxone. However, morphine pretreatment completely abolished the hypotensive and anti-diuretic effects of NT. 5. It is proposed that i.v. infusion of NT rapidly facilitates the secretion of an endogenous substance possessing potent antidiuretic properties and opiate mechanisms are involved in mediating such an effect. Although it appears unlikely, a role for vasopressin cannot be ruled out.

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Interaction of vasopressin with the nigro-striatal dopamine system: Site and mechanism of action

Cited by 24 publications

References 29 publications

Metabolism of angiotensin II is required for its in vivo effect on dopamine release in the striatum of the rat

Metabolism of angiotensin II is required for its in vivo effect on dopamine release in the striatum of the rat

Comparative Analysis of Vasotocin-Like Immunoreactivity in the Brain of the Turtle <i>Pseudemys scripta elegan </i><i>s</i> and the Snake <i>Python regiu</i><i>s</i> (Part 2 of 2)

Antidiuretic Effects of Neurotensin in Chloralose Anaesthetized Dogs

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