Interaction of vanadyl acetylacetonate with solvents: the 51V hyperfine interaction in mixtures of ethanol and carbon tetrachloride

Atherton, N. M.; Gibbon, P. J.; Shohoji, M. Cândida B. L.

doi:10.1039/dt9820002289

Cited by 15 publications

(19 citation statements)

References 2 publications

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“…The EPR spectra of the V IV -dipic complex, [VO(dipic) 2 ] 2À , in microemulsions were simulated by using the ASYM program, [95] which implements second-order corrections to the nuclear hyperfine interaction [96] and the line width dependence on vanadium nuclear spin. [84,97,98]…”

Section: Methodsmentioning

confidence: 99%

Correlation of Insulin‐Enhancing Properties of Vanadium‐Dipicolinate Complexes in Model Membrane Systems: Phospholipid Langmuir Monolayers and AOT Reverse Micelles

Sostarecz

Gaidamauskas

Distin

et al. 2014

Chemistry A European J

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We explore the interactions of V(III) -, V(IV) -, and V(V) -2,6-pyridinedicarboxylic acid (dipic) complexes with model membrane systems and whether these interactions correlate with the blood-glucose-lowering effects of these compounds on STZ-induced diabetic rats. Two model systems, dipalmitoylphosphatidylcholine (DPPC) Langmuir monolayers and AOT (sodium bis(2-ethylhexyl)sulfosuccinate) reverse micelles present controlled environments for the systematic study of these vanadium complexes interacting with self-assembled lipids. Results from the Langmuir monolayer studies show that vanadium complexes in all three oxidation states interact with the DPPC monolayer; the V(III) -phospholipid interactions result in a slight decrease in DPPC molecular area, whereas V(IV) and V(V) -phospholipid interactions appear to increase the DPPC molecular area, an observation consistent with penetration into the interface of this complex. Investigations also examined the interactions of V(III) - and V(IV) -dipic complexes with polar interfaces in AOT reverse micelles. Electron paramagnetic resonance spectroscopic studies of V(IV) complexes in reverse micelles indicate that the neutral and smaller 1:1 V(IV) -dipic complex penetrates the interface, whereas the larger 1:2 V(IV) complex does not. UV/Vis spectroscopy studies of the anionic V(III) -dipic complex show only minor interactions. These results are in contrast to behavior of the V(V) -dipic complex, [VO2 (dipic)](-) , which penetrates the AOT/isooctane reverse micellar interface. These model membrane studies indicate that V(III) -, V(IV) -, and V(V) -dipic complexes interact with and penetrate the lipid interfaces differently, an effect that agrees with the compounds' efficacy at lowering elevated blood glucose levels in diabetic rats.

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Section: Methodsmentioning

confidence: 99%

Correlation of Insulin‐Enhancing Properties of Vanadium‐Dipicolinate Complexes in Model Membrane Systems: Phospholipid Langmuir Monolayers and AOT Reverse Micelles

Sostarecz

Gaidamauskas

Distin

et al. 2014

Chemistry A European J

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“…Numerous studies of the VO(acac) 2 -adducts in methanol and other organic solvents have been done using a variety of spectroscopic methods including EPR and ENDOR. These investigations suggest that when the incoming group is methanol, it coordinates trans to the oxo group (47)(48)(49)(50). However, as the nucleophilicity of an incoming ligand increases, as in the case of alkyl-substituted pyridines, the geometry of the adduct changes to having the incoming ligand coordinated cis (relative to the oxo group) (51,52).…”

Section: Bis(maltolato)oxovanadium(i V) Andmentioning

confidence: 95%

Peroxo, Hydroxylamido, and Acac Derived Vanadium Complexes: Chemistry, Biochemistry, and Insulin-Mimetic Action of Selected Vanadium Compounds

Crans

1998

ACS Symposium Series

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In this chapter, the chemistry of selected vanadium compounds and their ability to inhibit phosphatases and exhibit insulin-mimetic activities will be described. First, chemical properties are presented for three target groups of vanadium compounds inducing insulin -mimetic responses. The simple vanadate salts represent the group of vanadium compounds most studied and exhibit the most complex chemistry. The chemistry of a new peroxovanadium(V) compound is presented and a corresponding, isoelectronic hydroxylamido vanadium(V) complex is characterized.The similarities and differences between peroxovanadium and hydroxylamido compounds are identified.Bis(2,4-pentanedionato-O,O')oxovanadium(IV) (VO(acac) 2 ) derivatives undergo hydrolysis reactions in aqueous solution which must be unraveled in order to appropriately interpret biological studies. Second, the effect of coordination number of vanadium compounds on their potency as a transition state analog inhibitor for a phosphatase is described.The five-coordinate vanadium(V) dipicolinic acid complex is found to be a more potent inhibitor than the six-coordinate vanadium(IV) dipicolinic acid complex and the seven-coordinate peroxooxovanadium(V) dipicolinic acid complex because of the structural analogy with the transition state of phosphate ester hydrolysis. Third, the effects of four types of peroxovanadium(V) compounds in phosphatase, insulin receptor and glucose-uptake assays are determined. The results show that although a series of peroxo compounds have significantly higher activity than vanadate in cell culture assays, such large differences are no longer apparent in the rat epitochlearis muscle.The insulin-mimetic effects of simple vanadium salts have prompted exploration of the insulin-mimetic properties of new, as well as other known vanadium complexes with organic ligands (2-9). Despite advances, little is known concerning the detailed 82

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“…With some solvents, the interaction (e.g. hydrogen bonding) with the O‐oxido ligand has also been proposed . For example, IR studies with pyridine derivatives demonstrated the existence of adducts with the sixth ligand bound cis rather than trans to the oxido O‐atom (Figure ), and ENDOR studies showed that while for example, methanol binds to the vacant axial 6 th position, it was shown that either cis or trans isomers are formed with some substituted pyridines .…”

Section: Introductionmentioning

confidence: 99%

Interaction of [V^IVO(acac)₂] with Human Serum Transferrin and Albumin

Correia

Chorna

Cavaco

et al. 2017

Chemistry An Asian Journal

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[VO(acac) ] is a remarkable vanadium compound and has potential as a therapeutic drug. It is important to clarify how it is transported in blood, but the reports addressing its binding to serum proteins have been contradictory. We use several spectroscopic and mass spectrometric techniques (ESI and MALDI-TOF), small-angle X-ray scattering and size exclusion chromatography (SEC) to characterize solutions containing [VO(acac) ] and either human serum apotransferrin (apoHTF) or albumin (HSA). DFT and modeling protein calculations are carried out to disclose the type of binding to apoHTF. The measured circular dichroism spectra, SEC and MALDI-TOF data clearly prove that at least two VO-acac moieties may bind to apoHTF, most probably forming [V O(acac)(apoHTF)] complexes with residues of the HTF binding sites. No indication of binding of [VO(acac) ] to HSA is obtained. We conclude that V O-acac species may be transported in blood by transferrin. At very low complex concentrations speciation calculations suggest that [(VO)(apoHTF)] species form.

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Interaction of vanadyl acetylacetonate with solvents: the 51V hyperfine interaction in mixtures of ethanol and carbon tetrachloride

Cited by 15 publications

References 2 publications

Correlation of Insulin‐Enhancing Properties of Vanadium‐Dipicolinate Complexes in Model Membrane Systems: Phospholipid Langmuir Monolayers and AOT Reverse Micelles

Correlation of Insulin‐Enhancing Properties of Vanadium‐Dipicolinate Complexes in Model Membrane Systems: Phospholipid Langmuir Monolayers and AOT Reverse Micelles

Peroxo, Hydroxylamido, and Acac Derived Vanadium Complexes: Chemistry, Biochemistry, and Insulin-Mimetic Action of Selected Vanadium Compounds

Interaction of [V^IVO(acac)₂] with Human Serum Transferrin and Albumin

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Interaction of vanadyl acetylacetonate with solvents: the 51V hyperfine interaction in mixtures of ethanol and carbon tetrachloride

Cited by 15 publications

References 2 publications

Correlation of Insulin‐Enhancing Properties of Vanadium‐Dipicolinate Complexes in Model Membrane Systems: Phospholipid Langmuir Monolayers and AOT Reverse Micelles

Correlation of Insulin‐Enhancing Properties of Vanadium‐Dipicolinate Complexes in Model Membrane Systems: Phospholipid Langmuir Monolayers and AOT Reverse Micelles

Peroxo, Hydroxylamido, and Acac Derived Vanadium Complexes: Chemistry, Biochemistry, and Insulin-Mimetic Action of Selected Vanadium Compounds

Interaction of [VIVO(acac)2] with Human Serum Transferrin and Albumin

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Interaction of [V^IVO(acac)₂] with Human Serum Transferrin and Albumin