Interaction of Uranyl Ions with Daunorubicin and Adriamycin

Abstract

The interaction of the uranyl(VI) ion (UO 2 2+ ) with two anthracyclines, adriamycin (Adr) and daunorubicin (Dnr), has been studied by absorption, circular dichroism, fluorescence and NMR spectroscopy. We have shown that both drugs can form two complexes with UO 2 2+ , a process strongly dependent on the dielectric constant of the solvent, the metal-to-ligand ratio (R), and the pH. The first complex (I) involves coordination of the metal ion to the [C(11)−O − , C(12)=O] chelating site, while the second complex (II) involves coordination to the [C(6)−O − , C(5)=O] site. In aqueous solutions at pH 6.5,

Mononuclear metal complexes with Piroxicam: Synthesis, structure and biological activity

“…The role of iron [73][74][75] is well known in human body proteins responsible for electron and oxygen transport. Uranyl ion is used in the study of biological systems with electronic microscopy mainly because of its high affinity to the phosphate group of DNA [76][77][78][79].…”