Interaction of tributyl- and triphenyltin with the microsomal monooxygenase system of molluscs and fish from the Western Mediterranean

Morcillo, Yolanda; Porte, Cinta

doi:10.1016/s0166-445x(96)00841-7

Cited by 48 publications

(19 citation statements)

References 31 publications

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“…Our results seems to confirm this observation. In Guanabara Bay the actual absence of the organism in previously reported sites is an additional evidence of impact (Huet et al, 1996;Minchin & Minchin, 1997;Smith, 1996) that may be derived from TBT, especially when mussels are abundant (Morcillo & Porte, 1997).…”

Section: Figure 4bmentioning

confidence: 81%

“…Besides causing hormonal disruption, evidences that organotins seem to act upon the immune system of mammals (cetacean, rabbits, rats and sheep) (Dacasto et al, 1994a(Dacasto et al, , 1994bKannan & Falandysz, 1997; and invertebrates (mollusks and tunicates) (Cima et al, 1995;Morcillo & Porte, 1997) call for epidemiological investigations focused upon sensitive populations.…”

Section: Introductionmentioning

confidence: 99%

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Occurrence of imposex in Thais haemastoma: possible evidence of environmental contamination derived from organotin compounds in Rio de Janeiro and Fortaleza, Brazil

et al. 2002

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There are indications that the widespread use of organotin compounds (TBT and TPT) as antifoulings, as stabilizers in plastic and as pesticides, has severely affected several species of marine organisms. The most striking effect of TBT and TPT as hormonal disruptors is the development of male organs in females of gastropods, currently denominated imposex. This syndrome can lead to the sterilization and death of affected organisms. The present work gives an overview of the present state of knowledge on imposex occurrence and reports results of a survey conducted in Guanabara Bay, Rio de Janeiro and in several sites along the coast of Fortaleza, Ceará State. Different stages of imposex development were verified in this survey, however, the most prominent levels appeared associated to known spot sources of TBT and TPT.

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Section: Figure 4bmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Occurrence of imposex in Thais haemastoma: possible evidence of environmental contamination derived from organotin compounds in Rio de Janeiro and Fortaleza, Brazil

et al. 2002

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“…Krüner and Westernhagen (1995) showed experimentally that turbot (Scophthalmus maximus) displayed higher EROD activity with increasing temperatures, while Lange et al (1992) claimed higher EROD activity at lower temperatures in dab, and Sleiderink et al (1995b) even stated that in their investigations of EROD in North Sea dab the effect of water temperature was dominant over the effect of PCB contamination; EROD activity being higher at low temperatures. Thus, differences in water temperature between sampling stations may have obscured effects of PCB contamination on EROD activity or an existing reaction may even have been suppressed by chemicals such as tributyltin (TBT) (Fent and Stegeman 1993;Morcillo and Porte 1997) or tetrachlorobiphenyl (TCB), as found out by Monosson and Stegemann (1991) …”

Section: Resultsmentioning

confidence: 99%

Ethoxyresorufin O-deethylase (EROD) activity in the liver of dab ( Limanda limanda L.) and flounder ( Platichthys flesus L.) from the German Bight. EROD expression and tissue contamination

Westernhagen

Krüner

Broeg

1999

Helgoland Marine Research

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Abstract. Ethoxyresorufin O-deethylase (EROD) activity was measured in the liver of dab (Limanda limanda) and flounder (Platichthys flesus) from the German Bight (southern North Sea) and compared with muscle and liver polychlorinated biphenyl (PCB) concentrations in an attempt to relate EROD activity to PCB body burden. In none of the different datasets (species-, tissue-or matrixdependent) was a significant (P<0.05) correlation between PCB tissue contamination and EROD activity found. Yet EROD activity was significantly correlated with polycyclic aromatic hydrocarbons (PAH) levels (phenanthrene, fluoranthene, pyrene) in muscle tissue, indicating a possible dependence of EROD expression on other ubiquitous organic contaminants, thus making it a suitable biomarker for general pollution.

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“…It is well known that organotins influence several enzymes systems: 33,34 triphenyltin(IV)chloride, TPTCl, was found to reduce the activity of zymogens (trypsinogen and chymotrypsinogen) in the Pagrus major liver 35 and TBT and TPT affected the microsomal monooxygenase system in the Mullus barbatus liver. 36 Langerhans islets are altered or destroyed by TBT treatment, which probably affects their endocrine function. In addition, in the treated individuals, the spleen seemed of reduced size; the thymus was atrophied and the head kidney appeared with altered structure.…”

Section: Discussionmentioning

confidence: 99%

Effects of sublethal levels of tributyltin chloride on a new toxicity test organism, Liza saliens (osteichthyes, mugilidae): a histological study

D'Agati

Mansueto

et al. 2006

Applied Organom Chemis

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The histopathological effects of 10 −7 and 10 −9 M tributyltin(IV)chloride,TBTCl, solutions on different Liza saliens organs have been studied by light microscope. The fish were sacrificed after 3-4 h incubation in 10 −7 M TBTCl solution or after 15 days incubation in 10 −9 M solution. The observed histopathological changes were dose-and time-dependent. The 10 −7 M TBTCl concentration resulted in major damage to the gill epithelium, indicating that TBTCl primarily interfered with the respiration, osmoregulation, acid balance and nitrogenous waste excretion processes. After incubation in 10 −9 M TBTCl solution the fish lived 20 or more days, but many of the organs were altered. Thymus atrophy, reduced spleen and altered head kidney were observed. These histological results indicated that TBTCl interfered with organ immunodefense and altered main metabolic pathways in Liza saliens. The presence of melano-macrophage centers, only in TBT-treated liver and spleen, can be considered a tool to facilitate, with other biomarkers, the detection of alterations by toxicants. Regarding the pancreas activity in 10 −7 M solutions, it has been noted that, in the exocrine cells, very few zymogen granules were still present and the Langerhans islets were more altered. In 10 −9 M solution the exocrine pancreatic cells had no granules and the islet cells presented degenerative alterations. In addition, TBTCl, which altered the pancreas and gonad morphology, could again be considered an endocrine disrupter even if biochemical data are still necessary. Finally, the Liza saliens juveniles could be considered an interesting biological model for experiments with contaminants, due to their ease of adaptation to experimental conditions and food chain position.

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Interaction of tributyl- and triphenyltin with the microsomal monooxygenase system of molluscs and fish from the Western Mediterranean

Cited by 48 publications

References 31 publications

Occurrence of imposex in Thais haemastoma: possible evidence of environmental contamination derived from organotin compounds in Rio de Janeiro and Fortaleza, Brazil

Occurrence of imposex in Thais haemastoma: possible evidence of environmental contamination derived from organotin compounds in Rio de Janeiro and Fortaleza, Brazil

Ethoxyresorufin O-deethylase (EROD) activity in the liver of dab ( Limanda limanda L.) and flounder ( Platichthys flesus L.) from the German Bight. EROD expression and tissue contamination

Effects of sublethal levels of tributyltin chloride on a new toxicity test organism, Liza saliens (osteichthyes, mugilidae): a histological study

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