2011
DOI: 10.1128/aem.01610-10
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Interaction of Transcriptional Repressor ArgR with Transcriptional Regulator FarR at the argB Promoter Region in Corynebacterium glutamicum

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Cited by 17 publications
(9 citation statements)
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“…This is consistent with studies in other bacteria where ArgR protein activity is activated and stabilized by arginine addition, while many other transcriptional regulators of the ADI pathway function in an arginine‐independent manner (Van Duyne et al, ; Larsen et al ., ; Zeng et al ., ; Makhlin et al ., ; Fulde et al, ). To the best of our knowledge, although both of these two regulators have previously been established to transcriptionally regulate the arc operons or some other target genes separately or simultaneously via binding to the promoter binding sites (Lu et al ., ; Larsen et al ., ; Lee et al ., ), it is the first time that the direct interaction between FNR and ArgR proteins has been demonstrated. These findings present promising implications for future studies to further elucidate cooperative regulatory mechanisms of ArgR and FNR for bacterial anaerobic adaptation and arginine metabolism.…”
Section: Discussionmentioning
confidence: 99%
“…This is consistent with studies in other bacteria where ArgR protein activity is activated and stabilized by arginine addition, while many other transcriptional regulators of the ADI pathway function in an arginine‐independent manner (Van Duyne et al, ; Larsen et al ., ; Zeng et al ., ; Makhlin et al ., ; Fulde et al, ). To the best of our knowledge, although both of these two regulators have previously been established to transcriptionally regulate the arc operons or some other target genes separately or simultaneously via binding to the promoter binding sites (Lu et al ., ; Larsen et al ., ; Lee et al ., ), it is the first time that the direct interaction between FNR and ArgR proteins has been demonstrated. These findings present promising implications for future studies to further elucidate cooperative regulatory mechanisms of ArgR and FNR for bacterial anaerobic adaptation and arginine metabolism.…”
Section: Discussionmentioning
confidence: 99%
“…FarR also represses the expression of the argB, argC, argG, argH, gdh and pgl genes ( Fig. 1) in the intracellular presence of L-arginine at high concentration 16,17 . Thus, the argR and farR genes were knocked out to construct the AR2 strain, which produced L-arginine to a higher concentration than AR1 by 5 g l À 1 in the flask cultivation (Supplementary Tables 1 and 2).…”
Section: Random Mutagenesis and Inactivation Of The Repressorsmentioning
confidence: 89%
“…This effect is mediated by ArgR, a hexameric protein that represses arginine biosynthesis genes, using L-arginine as co-repressor, in Escherichia coli [1] and Pseudomonas [2]. A similar effect is exerted by the homologous regulatory protein AhrC in Bacillus subtilis [3] or Lactococcus [4] and by ArgR in Corynebacterium [5].…”
Section: Introductionmentioning
confidence: 99%