Interaction of the Mucosal Immune and Peripheral Nervous Systems

Stead, R. H.; Tomioka, Motoaki; Pezzati, Paola; Marshall, Jean S.; Croitoru, Ken; Perdue, Mary H.; Stanisz, Andrzej; Bienenstock, John

doi:10.1016/b978-0-12-043780-1.50010-5

Cited by 12 publications

(6 citation statements)

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“…A growing body of data suggests the innervation of immunocompetent cells of the gut-associated lymphoid tissues (GALT). 1,2 Interactions between intestinal mucosal mast cells and nerves have been studied extensively. 3±5 Bani-Sacchi et al reported a decrease in the stainability of IMMC in the ileum following field stimulation of isolated bowel loops.…”

Section: Introductionmentioning

confidence: 99%

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Effect of truncal vagotomy and capsaicin on mast cells and IgA‐positive plasma cells in rat jejunal mucosa

Gottwald

Lhoták

Stead

1997

Neurogastroenterology Motil

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Immunocompetent cells, including mast cells and plasma cells (PC), in the intestinal mucosa are closely apposed to nerve fibres. Recent work has shown that vagal afferent nerves penetrate the jejunal mucosa and contact intestinal mucosal mast cells (IMMC); and that electrical stimulation of the vagus results in increased IMMC histamine content. To determine if the vagus nerve exerts a trophic effect on immunocompetent cells in the gut mucosa, the effects of truncal vagotomy and neonatal capsaicin treatment on IMMC and IgA containing PC in the lamina propria of rat jejunum were investigated. Three weeks after vagotomy, microdensitometric assessment of Alcian blue stained sections revealed 25% fewer IMMC in vagotomized animals than in controls (P < 0.05). Three months after neonatal capsaicin administration 28% fewer IMMC were found in treated rat jejunum, compared with littermate controls (P < 0.05). Three weeks post-surgery, IgA-PC densities were increased in both vagotomized animals (that also underwent pyloroplasty) and pyloroplasty controls, compared to animals subjected to laparotomy only. The proportion of lamina propria areas remained stable, indicating that the observations reflected real reductions in the numbers of IMMC. We also determined the densities of B-50 (a nerve growth-associated protein, also called GAP-43) immunoreactive nerve fibres in the lamina propria, as well as nerve profile areas, three weeks after vagotomy, and these parameters were unchanged. Taken together, these findings support the hypothesis that the vagus exerts a trophic effect on IMMC; and that capsaicin-sensitive nerves also affect the IMMC population. These data add to the growing body of evidence for a functional connection between IMMC and the nervous system.

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Section: Introductionmentioning

confidence: 99%

“…one-way analysis of variance (ANOVA) was employed using Minitab1 statistical software (Minitab Inc., PA, USA). For pairwise comparisons Tukey's tests (Minitab) were used.…”

mentioning

confidence: 99%

Effect of truncal vagotomy and capsaicin on mast cells and IgA‐positive plasma cells in rat jejunal mucosa

Gottwald

Lhoták

Stead

1997

Neurogastroenterology Motil

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“…In addition, antigeninduced immune responses may significantly alter mucosal neuroendocrine structure, sensitivity, and/or function (Stead et al, 1987(Stead et al, , 1991Weisz-Carrington, 1987;Bienenstock, 1993;Wira and Prabhala, 1993;Wood, 1993;Lambert et al, 1994;Gao et al, 1995;Sullivan and Edwards, 1997;Sullivan, 1997;Sullivan et al, 1998;Befus et al, 1999;Di Comite et al, 2007).…”

Section: Neuroendocrine Modulationmentioning

confidence: 98%

Ocular Mucosal Immunity

O’Sullivan

Montgomery

2015

Mucosal Immunology

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“…We attribute the decrement of both ATB-positive MCs and rCTMC-like MCs on ABS examination to the continuous alteration o f granular properties which led finally to the granule depletion during the course of active inflammation. Close apposition of MCs to the nerve fibres has often been reported under both physiological [30] and patholog ical [31] conditions. Degranulation of MCs induced by local release o f substance P from peripheral sensory nerve fibres has been proposed [8][9][10][11], In vitro.…”

Section: Discussionmentioning

confidence: 99%

Mast Cells Alter Granular Properties and Spatial Relation to Nerve Fibres in Spondylitis of Adjuvant-Treated Rats

Imai

Hukuda²,

Maeda³

1994

Int Arch Allergy Immunol

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It has been long implicated that mast cells (MCs) have a close spatial relationship to the peripheral nerve fibres. In the present study, which used spondylitis of adjuvant-treated rats, we investigated the behaviour of MCs in relation to peripheral nerve fibres and other inflammatory cells. Rat MCs with staining properties like connective tissue MCs decreased in number as inflammation progressed. With additional electron microscopic studies it was possible to observe the sequence of changes in their granular ultrastructure during active inflammation. Thus, the decrement of MCs with staining properties like connective tissue MCs was attributable to the changes in their granular conformation. In contrast, enzyme histochemistry of nerve fibres indicated that the percentages of MCs which were distant from nerve fibres increased significantly during the early stage of inflammation (p < 0.01). We speculate that while other inflammatory cells infiltrate, MCs deviate actively form nerve fibres and release their granular content.

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Interaction of the Mucosal Immune and Peripheral Nervous Systems

Cited by 12 publications

References 1 publication

Effect of truncal vagotomy and capsaicin on mast cells and IgA‐positive plasma cells in rat jejunal mucosa

Effect of truncal vagotomy and capsaicin on mast cells and IgA‐positive plasma cells in rat jejunal mucosa

Ocular Mucosal Immunity

Mast Cells Alter Granular Properties and Spatial Relation to Nerve Fibres in Spondylitis of Adjuvant-Treated Rats

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