Interaction of the fluoroquinolone antibiotic, ofloxacin, with titanium oxide nanoparticles in water: Adsorption and breakdown

Wieren, Emily M. Van; Seymour, Michael D.; Peterson, Jonathan W.

doi:10.1016/j.scitotenv.2012.09.067

Cited by 64 publications

(25 citation statements)

References 33 publications

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“…This value is consistent with previously-published results (1288 ± 217) L/kg (Van Wieren et al, 2012) from an isotherm at nearly the same pH (6 vs. 6.1). Example spectra are illustrated in Supp.…”

Section: Sorption Of Oflsupporting

confidence: 93%

“…For example, sorption and removal of the FQ, ofloxacin, have been demonstrated (Van Wieren et al, 2012). That study focused on isotherms at different pH and presented evidence based on LC/MS data for the removal of OFL parent molecule from solution, as well as the simultaneous generation of FQ degradation products, without detailed understanding of the mechanisms.…”

Section: Introductionmentioning

confidence: 99%

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Surface interactions and degradation of a fluoroquinolone antibiotic in the dark in aqueous TiO2 suspensions

Peterson

Seymour

2015

Science of The Total Environment

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Fluoroquinolone antibiotics (FQs) are important drugs used in human and veterinary medicine. Their detection in natural waters and waste water treatment plants, along with increased resistance to FQs among some bacteria, have generated an increased interest in the fate of these drugs in the environment. Partitioning of FQs between an aqueous solution and attendant substrates depends, in part, on the surface reactivity of the adsorbent, commonly a function of particle size, surface charge, and functional groups. This study investigated the surface interactions between the FQ drug ofloxacin (OFL) and titanium oxide (TiO2), a common catalyst and widely-observed constituent in many consumer products. Raman and fluorescence spectroscopic techniques, as well as LC/MS, were used to determine the OFL moieties present on TiO2 surfaces and in attendant solutions. Raman spectra indicate that the CO (ketone) group of the quinolone core, the NH(+) of the piperazinyl ring, and CH3 of benzoxazine core are the most active in sorption onto the TiO2 surface. Raman spectra also show that the sorbed benzoxazine-quinolone core and piperazinyl moieties are readily desorbed from the surface by re-suspending samples in water. Importantly, we found that OFL could be degraded by reacting with TiO2 even in the dark. Complementary LC/MS analysis of the attendant supernatants indicates the presence of de-piperazinylated and de-carboxylated OFL breakdown products in supernatant solutions. Together, both Raman and LC/MS analyses indicate that TiO2 breaks the compound into piperazinyl and carboxylate groups which attach to the surface, whereas de-carboxylated and hydroxylated quinolone moieties remain in solution. The present study thus identifies the sorption mechanisms and breakdown products of OFL during dark reactions with TiO2, which is critically important for understanding the fate and transport of OFL as it enters the soil and aquatic environment.

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Section: Sorption Of Oflsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Surface interactions and degradation of a fluoroquinolone antibiotic in the dark in aqueous TiO2 suspensions

Peterson

Seymour

2015

Science of The Total Environment

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“…In addition, 2-naphthol with two benzene rings has much stronger π-electron-conjugating potential than 2,4-dichlorophenol with one benzene ring . The adsorption of organic contaminants with -OH and -COOH functional groups on CNPs may be enhanced via hydrogen bonds (Vermisoglou et al, 2007;van Wieren et al, 2012). Yang et al (2008) indicated that the adsorption affinity of phenol or aniline on CNPs was enhanced with their substituted groups at a given position in the following order: nitro group>chloride group>methyl group, due to differences in the ability to form hydrogen bonds (Yang et al, 2008).…”

Section: Molecular Functional Groupsmentioning

confidence: 99%

“…Electrostatic interaction may be the dominant interaction for the adsorption of charged organic contaminants on CNPs (MacKay and Vasudevan, 2012), such as the adsorption of fluoroquinolone antibiotics (OFL and NOR) on CNTs, as affected by pH (Wang et al, 2009;Peng et al, 2012b). Hydrogen bonds can form between CNPs and organic contaminants if both chemicals and CNPs have certain functional groups, such as -OH, -COOH, -F, and -NH 2 (Vermisoglou et al, 2007;van Wieren et al, 2012). π-π interaction has also been used to interpret the adsorption of organic contaminants with a benzene ring or C=C double bond on the CNP surface (Chorover et al, 1999;Kulshrestha et al, 2004;Woods et al, 2007).…”

Section: Mechanisms Of Interaction Between Contaminants and Carbon Namentioning

confidence: 99%

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Organic contaminants and carbon nanoparticles: sorption mechanisms and impact parameters

Peng

Zhang

et al. 2014

J. Zhejiang Univ. Sci. A

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Carbon nanoparticles (CNPs) are novel manufactured materials with unique properties and have potential for a variety of applications. Adsorption of organic contaminants by discharged CNPs may affect the fate and transport of organic contaminants in the environment. This review summarizes the present research progress regarding organic contaminant adsorption on CNPs, and provides important information for the evaluation of the environmental behavior of organic contaminants and the risks associated with the use of CNPs. The main adsorption mechanisms involve hydrophobic interactions, π-π interactions, hydrogen bonds, and electrostatic interactions. These interactions may exist simultaneously, while the controlling adsorption mechanism differs depending on the properties of both the organic contaminants and the CNPs along with environmental conditions. The status of CNPs in the environment greatly affects or even controls their characteristics for adsorption of organic contaminants. The mobility and transport of dispersed CNPs and CNP-adsorbed organic contaminants could be promoted in natural aqueous environments, potentially increasing the spread of various organic contaminants and their associated environmental risks. Investigating the adsorption mechanisms and impact parameters is vital in predicting the environmental behaviors of both organic contaminants and CNPs and their associated risks.

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Changes in Toxicant Physicochemistry and Bioavailability During Sorption/Desorption Processes with TiO ₂ Nanoparticles in the Aqueous Phase

Patsiou

McCoustra

Fernandes

et al. 2022

Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems

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Interaction of the fluoroquinolone antibiotic, ofloxacin, with titanium oxide nanoparticles in water: Adsorption and breakdown

Cited by 64 publications

References 33 publications

Surface interactions and degradation of a fluoroquinolone antibiotic in the dark in aqueous TiO2 suspensions

Surface interactions and degradation of a fluoroquinolone antibiotic in the dark in aqueous TiO2 suspensions

Organic contaminants and carbon nanoparticles: sorption mechanisms and impact parameters

Changes in Toxicant Physicochemistry and Bioavailability During Sorption/Desorption Processes with TiO ₂ Nanoparticles in the Aqueous Phase

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Interaction of the fluoroquinolone antibiotic, ofloxacin, with titanium oxide nanoparticles in water: Adsorption and breakdown

Cited by 64 publications

References 33 publications

Surface interactions and degradation of a fluoroquinolone antibiotic in the dark in aqueous TiO2 suspensions

Surface interactions and degradation of a fluoroquinolone antibiotic in the dark in aqueous TiO2 suspensions

Organic contaminants and carbon nanoparticles: sorption mechanisms and impact parameters

Changes in Toxicant Physicochemistry and Bioavailability During Sorption/Desorption Processes with TiO 2 Nanoparticles in the Aqueous Phase

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Product

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Changes in Toxicant Physicochemistry and Bioavailability During Sorption/Desorption Processes with TiO ₂ Nanoparticles in the Aqueous Phase