Interaction of the DRD3 and BDNF gene variants in subtyped bipolar disorder

Lee, Sheng-Yu; Chu, Chun-Hsien; Chang, Yun-Hsuan; Lin, Shih-Hung; Huang, San-Yuan; Tzeng, Nian‐Sheng; Kuo, Po-Hsiu; Lee, I Hui; Yeh, Tzung Lieh; Yang, Yen Kuang; Lu, Ru‐Band

doi:10.1016/j.pnpbp.2012.07.015

Cited by 18 publications

(11 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure shows the different phases of the study selection in the meta‐analysis. Information was collected from 22 reports that associated polymorphism Val66Met (rs6265) of the BDNF gene and bipolar disorder, including our study in a Mexican population . A total of 9,349 cases and 7,437 controls were analyzed.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, we observed an association between the Val66Met polymorphism and suicide attempt in patients with bipolar disorder (see Supplementary Table 1). Other studies have reported an association of the Val allele (31,32,34) and Met allele (19) of the Val66Met (rs6265) polymorphism with bipolar disorder. Possible explanations for the discrepancies may include differences in the clinical criteria for the selection of the patients.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

The role of brain‐derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case–control study, comorbidities, and meta‐analysis of 16,786 subjects

et al. 2014

View full text Add to dashboard Cite

Objectives The aim of this study was to evaluate the association of Val66Met brain‐derived neurotrophic factor (BDNF) polymorphism with bipolar disorder in (i) a meta‐analysis and (ii) a case–control study in a Mexican population. We also investigated the possible association of this polymorphism with clinical features. Methods We performed a keyword search of the PubMed and Web of Science databases. A total of 22 studies that have investigated the association of Val66Met (rs6265) with bipolar disorder were selected for inclusion and combined with random effects meta‐analysis, using allelic, additive, dominant, and recessive models. Finally, the single nucleotide polymorphism (rs6265) Val66Met in the BDNF gene was genotyped and compared between 139 patients with bipolar disorder and 141 healthy volunteers in a Mexican population. Results The pooled results from the meta‐analysis (9,349 cases and 7,437 controls) did not show a significant association in any of the models. The same results were obtained in our case–control study when analyzing the distribution of the genotypic frequencies of the Val66Met polymorphism in patients with bipolar disorder. However, when we analyzed the association between rs6265 and lifetime history of suicidal behavior, we found an association between genotype Val‐Val and suicide attempt (p = 0.02). Conclusions Although the present study has some limitations, the results indicate a lack of association between the Val66Met polymorphism and bipolar disorder. However, in our case–control study in a Mexican population, the Val66Met polymorphism was associated with suicidal behavior in patients with bipolar disorder. Nevertheless, it is important to consider potential interactions of the BDNF gene, the environment, and different inheritance patterns, when carrying out future genetic studies with larger samples.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

The role of brain‐derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case–control study, comorbidities, and meta‐analysis of 16,786 subjects

et al. 2014

View full text Add to dashboard Cite

show abstract

“…BDNF regulates serotonin systems and the survival of serotonin neurons (10). In our previous report, we suggested that 5-HTTLPR might be associated with the risk of BP-I among Kurdish population in Western Iran (2).…”

Section: Discussionmentioning

confidence: 92%

“…Different etiology and characteristics of BP-I and BP-II during the course of disease were confirmed by Lee et al (10) that reported the association of the BDNF Val66Met with BP-II but not with BP-I among Han Chinese population in Taiwan. They suggested the two types of disorder that might be genetically distinct (10). Furthermore, another study among Han Chinese population of Taiwan confirmed that the BDNF Val allele was not associated with BP-I, while this allele was associated with anxiety disorder comorbidity in BP-I (11).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Its Synergism with L/S Polymorphism in the Promoter Region of Serotonin Transporter in Bipolar I Disorder Patients in Western Iran

Rahimi

Gravand

Khazaie

et al. 2016

Iran J Psychiatry Behav Sci

View full text Add to dashboard Cite

Background: Brain-derived neurotrophic factor (BDNF) might involve in the pathogenesis of mental disorders. There are inconsistent reports related to the role of BDNF Val66Met in susceptibility to bipolar disorder (BD). Objectives: The aim of the present study was to investigate the role of BDNF Val66Met and its synergism with 5-HTT gene-linked polymorphic region (5-HTTLPR) variants in susceptibility to bipolar I disorder (BP-I) in Western Iran. Materials and Methods:In this case-control study, 153 patients with BP-I and 146 age-and gender-matched healthy individuals were investigated for BDNF and 5-HTTLPR variants using PCR-RFLP method. Results: The frequency of BDNF A (Met) allele in patients (17.7%) was slightly lower than that in controls (19.9%, P = 0.5). The concomitant presence of BDNF G (Val) and 5-HTTLPR S alleles tended to increase the risk of BP-I by 1.41 times (P = 0.064) compared to the combined presence of BDNF G and 5-HTTLPR L alleles. Also, interaction between BDNF G (Val) and 5-HTTLPR S tended to increase the risk of BP-I by 1.28-fold (P = 0.062) compared to the concomitant presence of BDNF A and 5-HTTLPR S alleles. Conclusions: This study, conducted for the first time on Kurdish population in Western Iran, did not indicate any association between BDNF Val66Met with BP-I. However, the interaction between BDNF and 5-HTTLPR variants tended to increase the susceptibility to BP-I.

show abstract

Neurogenetics and Nutrigenomics of Reward Deficiency Syndrome (RDS): Stratification of Addiction Risk and Mesolimbic Nutrigenomic Manipulation of Hypodopaminergic Function

Blum

Han

Giordano

et al. 2013

Omics for Personalized Medicine

View full text Add to dashboard Cite

Interaction of the DRD3 and BDNF gene variants in subtyped bipolar disorder

Cited by 18 publications

References 69 publications

The role of brain‐derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case–control study, comorbidities, and meta‐analysis of 16,786 subjects

The role of brain‐derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case–control study, comorbidities, and meta‐analysis of 16,786 subjects

Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Its Synergism with L/S Polymorphism in the Promoter Region of Serotonin Transporter in Bipolar I Disorder Patients in Western Iran

Neurogenetics and Nutrigenomics of Reward Deficiency Syndrome (RDS): Stratification of Addiction Risk and Mesolimbic Nutrigenomic Manipulation of Hypodopaminergic Function

Contact Info

Product

Resources

About