Interaction of the D<sub>1</sub>Receptor Antagonist Sch 23390 with the Central 5-HT System: Radioligang Binding Studies, Measurements of Biochemical Parameters and Effects on L-5-HTP Syndrome

Bischoff, Serge; Heinrich, Micheline; Krauss, J.; Sills, Matthew A.; Williams, Michael; Vassout, A.

doi:10.3109/10799898809048981

Cited by 40 publications

(15 citation statements)

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“…In contrast, we observed that this dose of systemic D-amphetamine produced an inhibition of striatal ACh efflux when the D 1 receptor antagonist SCH 23390 concomitantly was applied in substantia nigra pars reticulata. Although it generally is accepted that SCH 23390 is a selective dopamine D 1 receptor antagonist in vivo, this drug does show significant affinity at 5-HT 2 receptors (Hyttel, 1984;Bischoff et al, 1988). Because D-amphetamine can act not only as a potent releaser of dopamine but also has weaker activity as a releaser of 5-HT (Raiteri et al, 1975;Kuczenski et al, 1995), there is the possibility that interactions of SCH 23390 and D-amphetamine with nigral 5-HT mechanisms could contribute to the present results.…”

Section: Discussionmentioning

confidence: 68%

Substantia Nigra D₁Receptors and Stimulation of Striatal Cholinergic Interneurons by Dopamine: A Proposed Circuit Mechanism

Abercrombie

Deboer

1997

J. Neurosci.

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Dopamine release can regulate striatal acetylcholine efflux in vivo through at least two receptor mechanisms: (1) direct inhibition by dopamine D 2 receptors on the cholinergic neurons, and (2) excitation initiated by dopamine D 1 receptors. The neuroanatomical locus of the latter population of D 1 receptors and the pathway(s) involved in the expression of their influence are controversial issues. We have tested the hypothesis that D 1 receptors in substantia nigra pars reticulata are involved in the excitatory component of dopaminergic actions on striatal acetylcholine output. In vivo microdialysis was used in awake rats. Infusion of the selective D 1 receptor agonist R(ϩ)-1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol (SKF 38393) hydrochloride into pars reticulata of substantia nigra elicited a significant increase in striatal acetylcholine efflux. Likewise, D-amphetamine applied into pars reticulata of substantia nigra by reverse dialysis produced an elevation in acetylcholine output measured at a second microdialysis probe in the striatum. Application of D-amphetamine in the striatum by reverse dialysis elicited a decrease in striatal acetylcholine efflux that could be reversed subsequently by local application of Damphetamine in substantia nigra pars reticulata. A 2 mg/kg intraperitoneal dose of D-amphetamine, which has no net effect on striatal acetylcholine output under control conditions, elicited a significant decrease in acetylcholine efflux when the D 1 receptor antagonist R(ϩ)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SCH 23390) hydrochloride was applied simultaneously via a second microdialysis probe in substantia nigra pars reticulata. Thus, an excitatory D 1 -mediated influence on striatal acetylcholine output is initiated in substantia nigra pars reticulata, and this influence contributes to the effects of indirect dopaminergic agonists such as D-amphetamine on striatal acetylcholine efflux. These results indicate an important role of somatodendritic dopamine release, in addition to nerve terminal dopamine release, in the regulation of activity in basal ganglia circuits.

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Section: Discussionmentioning

confidence: 68%

Substantia Nigra D₁Receptors and Stimulation of Striatal Cholinergic Interneurons by Dopamine: A Proposed Circuit Mechanism

Abercrombie

Deboer

1997

J. Neurosci.

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“…tors (Bischoff et al 1986(Bischoff et al , 1988. Therefore, the impairments observed in the present study may be due to SCH23390 acting at 5-HT2 receptors.…”

Section: Prelimbic Cortex Learning and Dopaminementioning

confidence: 60%

The Effects of Dopamine D₁Receptor Blockade in the Prelimbic–Infralimbic Areas on Behavioral Flexibility

Ragozzino¹

2002

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160

159

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This study examined the effects of a dopamine D 1 antagonist, SCH23390, infused into the prelimbicinfralimbic areas on the acquisition of a response and visual-cue discrimination task, as well as a shift from a response to a visual-cue discrimination and vice versa. Each test was carried out in a cross-maze. The response discrimination required learning to always turn in the same direction (right or left) for a cereal reinforcement. The visual-cue discrimination required learning to always enter the arm with the visual cue. In experiment 1, rats were tested on the response discrimination task, followed by the visual-cue discrimination task. In experiment 2, the testing order was reversed. Bilateral infusions of SCH23390 (0.1 or 1 µg/0.5 µL) into the prelimbic-infralimbic areas did not impair acquisition of the response or visual-cue discrimination tasks. SCH23390 injections at 1 µg, but not 0.1 µg impaired performance when shifting from a response to a visual-cue discrimination, and vice versa. Analysis of the errors revealed that the deficit was due to perseveration of the previously learned strategy. These results suggest that activation of dopamine D 1 receptors in the prelimbic-infralimbic areas may be critical for the suppression of a previously relevant strategy and/or generating new strategies.There is accumulating evidence that separate prefrontal cortex regions influence distinct cognitive functions (Kolb et al. 1974;Eichenbaum et al. 1983;Seamans et al. 1995;Delatour and Gisquet-Verrier 1996Goldman-Rakic 1996;Kesner et al. 1996;Petrides 1996;Bussey et al. 1997;DeCoteau et al. 1997;Ragozzino et al. 1998Ragozzino et al. , 1999b GisquetVerrier et al. 2000;Kesner 2000;Ragozzino and Kesner 2001). Experiments in nonhuman primates have shown that different prefrontal cortex areas contribute to separate forms of cognitive flexibility (Dias et al. 1996(Dias et al. , 1997. Lesions of the lateral prefrontal cortex produce a selective impairment in extra-dimensional shifts for a visual-cue discrimination task (e.g., learning to make a choice based on shape, then learning to make a choice based on lines). However, lateral prefrontal cortex lesions do not impair reversal learning (e.g., learning to always choose a red object but not a blue object, then learning to choose the opposite colored object). Conversely, lesions of the orbital prefrontal cortex impair reversal learning but not extra-dimensional shifts (Dias et al. 1996(Dias et al. , 1997. Taken together, the evidence suggests that the lateral prefrontal cortex and orbital prefrontal cortex regions differentially contribute to cognitive flexibility based on the type of task demands.The findings from several studies in rodents suggest that the medial prefrontal cortex plays a critical role in behavioral flexibility (deBruin et al. 1994; Aggleton et al. 1995;Granon and Poucet 1995;Bussey et al. 1997;Joel et al. 1997; Ragozzino et al. 1999a,b;Birrell and Brown 2000;Delatour and Gisquet-Verrier 2000;Dias and Aggleton 2000). Recently, a series of experiments foun...

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“…Also, a spread of drug rostrally into the prelimbic-infralimbic cortex would not affect behavior, as these prefrontal subregions do not play a role in the form of decision making examined here: Walton et al (2003) demonstrated that excitotoxic lesions to the prelimbic-infralimbic cortex had no effect on rats' ability to make effort-based decisions. In addition, SCH23390 (Bischoff et al 1988) and eticlopride (Seeman and Ulpian 1988) are highly selective and potent antagonists at D1 or D2 receptors, respectively. Although SCH23390 displays affinity to 5-HT2 receptors as well (Bischoff et al 1988), actions on 5-HT2 receptors might not account for the SCH23390-induced behavioral effects.…”

Section: Discussionmentioning

confidence: 99%

Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision making

Schweimer

Hauber²

2006

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143

103

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The anterior cingulate cortex (ACC) has been implicated in encoding whether or not an action is worth performing in view of the expected benefit and the cost of performing the action. Dopamine input to the ACC may be critical for this form of effort-based decision making; however, the role of distinct ACC dopamine receptors is yet unknown. Therefore, we examined in rats the effects of an intra-ACC D1 and D2 receptor blockade on effort-based decision making tested in a T-maze cost-benefit task. In this task, subjects could either choose to climb a barrier to obtain a high reward in one arm or a low reward in the other arm without a barrier. Unlike vehicle-treated rats, rats with intra-ACC infusion of the D1 receptor antagonist SCH23390 exhibited a reduced preference for the high-costhigh-reward response option when having the choice to obtain a low reward with little effort. In contrast, in rats with intra-ACC infusion of the D2 receptor antagonist eticlopride, the preference for the high-cost-high-reward response option was not altered relative to vehicle-treated rats. These data provide the first evidence that D1 receptors in the ACC regulate effort-based decision making.In order to make adaptive decisions, subjects have to analyze costs and benefits of the available response options. A number of studies indicate that the anterior cingulate cortex (ACC), a major subregion of the prefrontal cortex, is involved in these evaluative processes and might serve to encode whether or not an action is worth performing in view of the expected benefit and the cost of performing the action (Rushworth et al. 2004). For instance, after excitotoxic ACC lesions, rats no longer selected the high-costhigh-reward option in a cost-benefit T-maze task if having the choice between climbing a barrier to obtain a large reward in one arm or to run for a low reward into the other arm with no barrier present (Walton et al. 2003).There is a large body of evidence to suggest that mesolimbic dopamine (DA) fibers projecting to the nucleus accumbens are critical for enabling an organism to overcome response costs to gain access to greater reward (Salamone et al. 1997). Recent studies indicate that mesocortical DA fibers projecting to the ACC (Berger et al. 1991) may be important in effort-based decision making as well. Like rats with excitotoxic lesions, rats with DA depletion of the ACC no longer chose effortful but high-reward action in a T-maze cost-benefit task . However, using the same task Walton et al. (2005) reported that DA depletion of the ACC had no effect on effort-based decision making. As Schweimer et al. (2005) infused a markedly higher dose of the catecholaminergic neurotoxin 6-hydroxydopamine into the ACC than Walton et al. (2005), different magnitudes of DA depletions may largely account for the discrepant results. Together, these two studies suggest that a substantial loss of DA in the ACC may be necessary to impair effort-based decision making.Prefrontal DA plays an essential role in cognitive processes and regulates aspect...

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Interaction of the D₁Receptor Antagonist Sch 23390 with the Central 5-HT System: Radioligang Binding Studies, Measurements of Biochemical Parameters and Effects on L-5-HTP Syndrome

Cited by 40 publications

References 14 publications

Substantia Nigra D₁Receptors and Stimulation of Striatal Cholinergic Interneurons by Dopamine: A Proposed Circuit Mechanism

Substantia Nigra D₁Receptors and Stimulation of Striatal Cholinergic Interneurons by Dopamine: A Proposed Circuit Mechanism

The Effects of Dopamine D₁Receptor Blockade in the Prelimbic–Infralimbic Areas on Behavioral Flexibility

Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision making

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Interaction of the D1Receptor Antagonist Sch 23390 with the Central 5-HT System: Radioligang Binding Studies, Measurements of Biochemical Parameters and Effects on L-5-HTP Syndrome

Cited by 40 publications

References 14 publications

Substantia Nigra D1Receptors and Stimulation of Striatal Cholinergic Interneurons by Dopamine: A Proposed Circuit Mechanism

Substantia Nigra D1Receptors and Stimulation of Striatal Cholinergic Interneurons by Dopamine: A Proposed Circuit Mechanism

The Effects of Dopamine D1Receptor Blockade in the Prelimbic–Infralimbic Areas on Behavioral Flexibility

Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision making

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Resources

About

Interaction of the D₁Receptor Antagonist Sch 23390 with the Central 5-HT System: Radioligang Binding Studies, Measurements of Biochemical Parameters and Effects on L-5-HTP Syndrome

Substantia Nigra D₁Receptors and Stimulation of Striatal Cholinergic Interneurons by Dopamine: A Proposed Circuit Mechanism

Substantia Nigra D₁Receptors and Stimulation of Striatal Cholinergic Interneurons by Dopamine: A Proposed Circuit Mechanism

The Effects of Dopamine D₁Receptor Blockade in the Prelimbic–Infralimbic Areas on Behavioral Flexibility