Interaction of surfactants with block-copolymer systems in the presence of Hofmeister anions

Self-Association in EO–BO–EO Triblock Copolymers as a Nanocarrier Template for Sustainable Release of Anticancer Drugs

“…Such a sharp decrease in γ is due to the adsorption of polymeric unimers at the air–water interface. In some cases, γ does not remain constant by addition of polymers because of the formation of dimers and trimers or clusters which reflect the dynamic nature of micellization. − …”

“…This enables the micellization at much lower copolymer concentrations which make them act as excellent drug delivery nanocarriers. Several groups have illustrated the solution behavior and self-associative properties of varied EO–BO–EO-based BCPs in aqueous medium using various fundamental physicochemical techniques, while a few studies have reported the mixed micellization of these copolymers. ,− In addition, the gelation and rheological behavior of these copolymers have also been reported for the drug solubilization and transport study as effective nanocarrier reservoirs for the sustained drug delivery for oral and topical administration. − …”

A Brief Discussion on Mixed Micelle Formed by Block Copolymer and Surfactant

“…Recently anionic surfactant boundblock copolymers have been became popular as it can solubilize wide range of drug molecules as well as it is more viscous compared non-ionic polymer mixed micellar system which is ideal forcontrolled drug delivery, also it provides good templates for nanostructured materials preparation [39][40][41].Triblock copolymers interact with ionic surfactants like surfactant sodium dodecyl sulfate (SDS), cetyl trimethyl ammonium bromide (CTAB) etc., in aqueous media and form mixed-micelles [44].Pluoronic copolymer form mixed micelle with anionic surfactant SDS in lower concentration regime i.e., < CMC…”

“…For the study, they have used the phenazinium dye, phenosafranin (PSF) as a model drug and monitored the interaction of PSF with F127 and F127SDS mixed system[43].Both spectroscopic and calorimetricexperiments prove that the drug binding efficiency gets enhanced when SDS is added into F127 micelle and this leads to mixed micelleformation between F127 and SDS. The micro-environment of the mixed micelle becomes more hydrophobic due to formation of more compact mixed-micelle formationthat improve physical stability and enhance drug loading capacities[43].Jadoon et al has studied the mixed micelleformation between block co-polymer with both cationic CTAB and anionic surfactant SDS[44]. After mixing of ionic and nonionic block copolymer surfactant the hydrodynamic radius grows into uniform distribution, which signifies that almost all surfactant molecules presentin the solution are in the micellar form[44].…”

“…The micro-environment of the mixed micelle becomes more hydrophobic due to formation of more compact mixed-micelle formationthat improve physical stability and enhance drug loading capacities[43].Jadoon et al has studied the mixed micelleformation between block co-polymer with both cationic CTAB and anionic surfactant SDS[44]. After mixing of ionic and nonionic block copolymer surfactant the hydrodynamic radius grows into uniform distribution, which signifies that almost all surfactant molecules presentin the solution are in the micellar form[44]. Rehman etal.…”