Interaction of substituted phenoxazine chemosensitizers with bovine serum albumin

Channu, B. C.; Kalpana, H. N.; Eregowda, G. B.; Dass, Chhabil; Houghton, Peter J.; Thimmaiah, Κ. N.

doi:10.1016/s0731-7085(99)00187-9

Cited by 29 publications

(16 citation statements)

References 13 publications

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“…[27] A comparison between POZ-and PTZ-based sensitizers showed that the POZ-based dye TH301 gave an efficiency of 6.2 % and the structurally similar PTZ-based T2-1 showed an efficiency of 5.5 % under similar conditions. [25,26] POZ dyes have been used in other applications, such as laser dyes, [31] indicators, [32] biological stains, [33] anticancer agents, [34] hole-transporting materials, [35] and in host-guest systems. [36] There are some general considerations to take into account for the design of a sensitizer for DSCs: 1) strong and broad light absorption for efficient light harvesting, 2) appropriate energy levels for efficient electron injection and dye regeneration, and 3) easy and reliable synthesis with cheap, nontoxic materials suitable for future large-scale production.…”

Section: à2mentioning

confidence: 99%

Phenoxazine Dyes for Dye‐Sensitized Solar Cells: Relationship Between Molecular Structure and Electron Lifetime

Karlsson

Jiang

Eriksson

et al. 2011

Chemistry A European J

108

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A series of metal-free organic dyes with a core phenoxazine chromophore have been synthesized and tested as sensitizers in dye-sensitized solar cells. Overall conversion efficiencies of 6.03-7.40% were reached under standard AM 1.5G illumination at a light intensity of 100 mW cm(-2) . A clear trend in electron lifetime could be seen; a dye with a furan-conjugated linker showed a shorter lifetime relative to dyes with the acceptor group directly attached to the phenoxazine. The addition of an extra donor unit, which bore insulating alkoxyl chains, in the 7-position of the phenoxazine could increase the lifetime even further and, together with additives in the electrolyte to raise the conduction band, an open circuit voltage of 800 mV could be achieved. From photoelectron spectroscopy and X-ray absorption spectroscopy of the dyes adsorbed on TiO(2) particles, it can be concluded that the excitation is mainly of cyano character (i.e., on average, the dye molecules are standing on, and pointing out, from the surface of TiO(2) particles).

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Section: à2mentioning

confidence: 99%

Phenoxazine Dyes for Dye‐Sensitized Solar Cells: Relationship Between Molecular Structure and Electron Lifetime

Karlsson

Jiang

Eriksson

et al. 2011

Chemistry A European J

108

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“…[2][3][4] In the other hand, phenoxazine derivatives are of considerable interest because of their important and impressive number of applications, e.g. as: biological stains, [5][6][7] laser dyes, 8) indicators, 9,10) and especially as chromophoric compounds in host-guest artificial photonic antenna systems. 11) They have also been used as covalent labeling of biomolecules 12) and for the synthesis of hydrophilic far-red dyes, that were synthesized and applied to detect enzymatic activities of two model proteases, trypsin and leucine aminopeptidase.…”

Section: Regular Articlementioning

confidence: 99%

A New Way for Synthesis of Phenoxazine and Diphenoxazine Derivatives via Electrochemical Method

Davarani

Bojdi

Mehdinia

2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Electrochemical oxidation of hydroquinone (1a) and 2,3-dimethylhydroquinone (1b) have been studied in the presence of 2-aminophenol (3a) and 2-amino-4-chlorophenol (3b), as nucleophiles in phosphate buffer solution (pH 7.2) using cyclic voltammetry and controlled potential coulometry. We proposed different mechanisms for the electrode process. The products were derived with good yield and purity using controlled-potential electrochemical oxidation of 1a, b in the presence of 3a and 3b at the graphite electrode in an undivided cell.

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“…The binding parameters were estimated by Eq. (2) for Scrathard analysis [5,9] or Eq. (3) for the Klotz plot [37] (2) …”

Section: Drug-protein Interaction Studies In Vitromentioning

confidence: 99%

“…Based on the procedures of separating mixtures of the bound and free drug, various methods, including equilibrium dialysis [4,5], ultrafiltration [6,7,8], microdialysis [9,10], and high-performance frontal analysis (HPFA) [11,12], followed by HPLC or CE have been developed for the indirect study of drug-protein interaction. Hage and Tweed have reviewed the chromatographic and electrophoretic methods for the study of drug-protein interactions [13].…”

Section: Introductionmentioning

confidence: 99%

A flow-injection ultrafiltration sampling chemiluminescence system for on-line determination of drug?protein interaction

Wang

Zhang

et al. 2003

Analytical and Bioanalytical Chemistry

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A flow-injection ultrafiltration sampling chemiluminescence system for on-line determination of cimetidine-bovine serum albumin (BSA) interaction is proposed in this paper. Cimetidine can be oxidized by N-bromosuccinimide (NBS) and sensitized by fluorescein to produce high chemiluminescence emission in basic media. The concentration of cimetidine is linear with the CL intensity in the range 3 x 10(-7) - 1 x 10(-4) mol L(-1) with a detection limit of 1 x 10(-7) mol L(-1) (3 sigma). The drug and protein were mixed in different molar ratios in 0.067 mol L(-1) phosphate buffer, pH 7.4, and incubated at 37 degrees C in a water bath. The ultrafiltration probe was utilized to sample the mixed solution at a flow rate of 5 micro L min(-1). The data obtained by the proposed ultrafiltration flow-injection chemiluminescence method was analyzed with Scrathard analysis and a Klotz plot. The estimated association constant ( K) and the number of the binding site ( n) on one molecule of BSA by Scrathard analysis and Klotz plot were 3.15 x 10(4) L mol(-1) and 0.95, 3.25 x 10(4) L mol(-1) and 0.92, respectively. The proposed system proved that flow-injection chemiluminescence analysis coupled with on-line ultrafiltration sampling is a simple and reliable technique for the study of drug-protein interaction.

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Interaction of substituted phenoxazine chemosensitizers with bovine serum albumin

Cited by 29 publications

References 13 publications

Phenoxazine Dyes for Dye‐Sensitized Solar Cells: Relationship Between Molecular Structure and Electron Lifetime

Phenoxazine Dyes for Dye‐Sensitized Solar Cells: Relationship Between Molecular Structure and Electron Lifetime

A New Way for Synthesis of Phenoxazine and Diphenoxazine Derivatives via Electrochemical Method

A flow-injection ultrafiltration sampling chemiluminescence system for on-line determination of drug?protein interaction

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