Interaction of solutions containing phenothiazines exposed to laser radiation with materials surfaces, in view of biomedical applications

Simon, Ágota; Alexandru, Tatiana; Boni, Mihai; Damian, Victor; Stoicu, Alexandru; Dutschk, Victoria; Pascu, Mihail-Lucian

doi:10.1016/j.ijpharm.2014.08.031

Cited by 9 publications

(12 citation statements)

References 41 publications

(67 reference statements)

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“…Surface activity modifications may lead to variations of the wetting properties of solution as well as of the speed with which modified VCM and resulting photoproducts are delivered and penetrate biological targets. This kind of effect was reported recently for phenothiazines which were subject of exposure to laser beams [13].…”

supporting

confidence: 69%

Surface properties of Vancomycin after interaction with laser beams

Dinache

Boni

Alexandru

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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supporting

confidence: 69%

Surface properties of Vancomycin after interaction with laser beams

Dinache

Boni

Alexandru

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…polyester (PES) materials as shown in [5], (10 and 5 times, respectively) in a recipient (≈ 1 L) utilizing warm tap water to eliminate contaminations. Basically, in [5], at the end of every washing/cleaning stage/cycle, the water's surface tension used for washing was measured, to compare it with the value of the clean tap water.…”

Section: Interaction Of Unirradiated and Irradiated Phenothiazines Wimentioning

confidence: 99%

“…Basically, in [5], at the end of every washing/cleaning stage/cycle, the water's surface tension used for washing was measured, to compare it with the value of the clean tap water. In the case of the CO surfaces, after 10 cycles the used water's surface tension reached the clean water's value.…”

Section: Interaction Of Unirradiated and Irradiated Phenothiazines Wimentioning

confidence: 99%

“…In this case S and Cl maps have been extracted from the whole spectra. Morphology investigations performed by Scanning electron microscopy (SEM) have given a microscale insight in the wetting properties of irradiated and not irradiated samples observed in [5,7]. In Fig.7 the unirradiated PMZ sample seems to accumulate in zones of the fabric without a more homogeneous distribution (see maps of S and Cl)…”

Section: Interaction Of Unirradiated and Irradiated Phenothiazines Wimentioning

confidence: 99%

“…More recent studies show that solutions of phenothiazines in water once exposed to laser radiation have modified wetting properties with respect to fabrics [5]. These data suggest to extend the toxicity studies of phentothiazines exposed to laser radiation towards applications on cell cultures and to broaden the studies of their wetting properties on fabrics in view of further applications.…”

Section: Introductionmentioning

confidence: 95%

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Toxicity study in blood and tumor cells of laser produced medicines for application in fabrics

Morán

Tozar

Simon

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Phenothiazine derivatives are non-antibiotics with antimicrobial, fungistatic and fungicidal effects. We exposed to a high energy UV laser beam phenothiazines solutions in water at 20mg/mL concentration to increase antibacterial activity of resulting mixtures. Compared to previous results obtained on bacteria, more research is needed about UV laser irradiated phenothiazines applications on cancer cell cultures to evidence possible anticancerous properties. Evaluation of the safety of the newly obtained photoproducts in view of use on humans is also needed. Due to expensive animal testing in toxicology and pressure from general public and governments to develop alternatives to in vivo testing, in vitro cell-based models are attractive for preliminary testing of new materials. Cytotoxicity screening reported here shows that laser irradiated (4h exposure time length) chlorpromazine and promazine are more efficient against some cell cultures. Interaction of laser irradiated phenothiazines with fabrics show that promethazine and chlorpromazine have improved wetting properties. Correlation of these two groups of properties shows that chlorpromazine appears to be more recommended for applications on tissues using fabrics as transport vectors. The reported results concern stability study of phenothiazines water solutions to know the time limits within which they are stable and may be used.

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Influence of bath temperatures on the wettability of copper films surface prepared by electroless plating method on beech wood

Amer

Mrad

Naddaf

2016

Surface & Interface Analysis

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Copper films were coated on beech wood substrates by electroless plating method. The influence of bath temperature on the copper films properties was studied by varying the bath temperatures 25, 35, 45 and 55 °C. Scanning electron microscopy (SEM) equipped with energy dispersive spectroscopy (EDS), X‐ray diffraction (XRD) pattern, X‐ray photoelectron spectroscopy (XPS), micro Raman spectroscopy and contact angle measurements were used to both characterize the physical and chemical copper films properties and understand the influence of bath temperature on the wettability of copper surface. In our studies, we have found that the gained copper mass significantly increased at 55 °C. The crystalline nature of the coated copper was confirmed by XRD. The presence of Cu2O and CuO was observed by XPS and micro Raman techniques, which confirms the oxidization of the coated copper surface. Also these characterization techniques have shown the big influence of bath temperature on the morphology, grain size, chemical composition and the film thickness of the coated copper. The wettability was highly influenced by increasing CuO on the coated copper, which is increased by the bath temperature. The contact angle measurements have demonstrated the influence of C―O, O―CO and CuO components of the surface on the wettability of the samples. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Interaction of solutions containing phenothiazines exposed to laser radiation with materials surfaces, in view of biomedical applications

Cited by 9 publications

References 41 publications

Surface properties of Vancomycin after interaction with laser beams

Surface properties of Vancomycin after interaction with laser beams

Toxicity study in blood and tumor cells of laser produced medicines for application in fabrics

Influence of bath temperatures on the wettability of copper films surface prepared by electroless plating method on beech wood

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