Interaction of six candidate genes in essential hypertension

Hu, Deming; Zhao, Xiaoli; Shao, Jianchun; Wang, W.; Qian, Jie; Chen, A.H.; Zhang, H.Q.; Guo, Hong; Jiang, Jun-Ran; Li, H.Y.

doi:10.4238/2014.october.20.14

Cited by 10 publications

(6 citation statements)

References 22 publications

(32 reference statements)

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“…Studies indicate the existence of genetic interactions between renin-angiotensin system loci [63,64] and endothelial nitric oxide synthase polymorphisms [65]. In the present work, interactions of different types and intensity were verified, among GRK4, ACE, NOS3, AGT, and AGR1 gene polymorphisms (Figures 1 and 2).…”

Section: Discussionsupporting

confidence: 75%

Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption

Silva

Costa

Aguiar

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. Cardiovascular risk (CVR) underlies aging process and longevity. Previous work points to genetic and environmental factors associated with this risk. Objectives. The aim of this research is to look for any CVR gene-gene and gene-multifactorial/lifestyle interactions that may impact health and disease and underlie exceptional longevity. Methods. A case-control study involving 521 both gender individuals, 253 centenarians (100.26±1.98 years), and 268 controls (67.51±3.25 years), low (LCR, n=107) and high (HCR, n=161) CVR. Hypertension, diabetes, obesity (BMI, kg·m-2), and impaired kidney function were defined according to standard criteria. CVR was calculated using Q risk®. DNA was genotyping (ACE-rs4646994, AGT-rs4762, AGR1-rs5182, GRK4-rs2960306, GRK4-rs1024323, NOS3-rs1799983, and SLC12A3-rs13306673) through iPlex-MassARRAY®, read by MALDI-TOF mass spectrometry, and analyzed by EARTDECODE®. Results. Antilongevity factors consisted (OR 95% CI, p<0.05) BMI 1.558 (1.445-1.680), hypertension 2.358 (1.565-3.553), smoking habits 4.528 (2.579-7.949), diabetes 5.553 (2.889-10.675), hypercholesterolemia 1.016 (1.010-1.022), and regular consumption of red meat 22.363 (13.987-35.755). Genetic aspects particularly for HCR individuals ACE II (OR: 3.96 (1.83-8.56), p<0.0001) and NOS3 TT (OR: 3.11 (1.70-5.70), p<0.0001) genotypes were also risk associate. Obesity, smoking, hypercholesterolemia, and frequent consumption of red meat have an additive action to hypertension in the longevity process. There was a synergistic interaction between the endothelial NOS3 genotypes and the severity of arterial hypertension. An epistatic interaction between functional genetic variants of GRK4 and angiotensinogen was also observed. Conclusions. Cardiovascular risk-related genetic and multifactorial or predominantly lifestyle aspects and its interactions might influence the aging process and contribute to exceptional longevity in Portuguese centenarians. Besides lifestyle, the activity of nitrite oxide synthase may be one of the main physiologic regulators of cardiovascular protection in the path of longevity.

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Section: Discussionsupporting

confidence: 75%

Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption

Silva

Costa

Aguiar

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…The ACE gene produces 2 isoforms: 1) endothelial or somatic form which is expressed in many tissues, including vascular endothelial cells, renal epithelial cells, Leydig cells, duodenum, lungs, pulmonary blood vessels, prostate and 2) testicular form that is expressed only in sperm [21].…”

Section: Resultsmentioning

confidence: 99%

Angiotensin-converting enzyme gene: application possibilities in medicine and sports cardiology (literature review)

Malakhova

2018

ZMJ

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Aim. Formation of modern ideas about the effect of angiotensin-converting enzyme polymorphism on the functioning of various body systems including in athletes. Methods of research.Analysis and synthesis of the modern scientific literature data.Results. According to modern ideas of sport molecular genetics, individual differences in the expression degree of certain physical and mental qualities of a person are largely determined by DNA-polymorphisms. Specific features of angiotensin converting enzyme I/D gene polymorphism influence on life-supporting systems functioning of human, who do not engage in sports, have been revealed. This polymorphism is widely covered by professional athletes from the point of view of physical qualities development possibility, but at the same time, the risk of pathological conditions development, taking into account regular intensive physical exertion, has not sufficiently studied. Knowledge of the innate personal physical abilities will help to predict the strengths and weaknesses of a person's physical and adaptive capabilities and, accordingly, to make a timely correct prognosis for personal sports prospects and carry out competent selection of athletes. This approach will allow them to progress quickly and achieve high results in sport. Conclusions.A feature of genetic markers that do not change throughout life is the possibility of their determination immediately after child's birth, thus, the prognosis for indicators development that are significant in the conditions of sport activities can be made much earlier. In the available to us literature, ACE I/D gene polymorphism is primarily evaluated from the perspective of speed-strength development of physical qualities, but at the same time, genetic testing of beginner athletes should allow us to identify a risk group relatively to a number of pathological conditions progression that are genetically determined. Thus, despite numerous studies that allow an assessment of ACE gene polymorphism contribution to the life-supporting organs and systems state, the role of the ACE gene remains being insufficiently studied in sports medicine.Ген ангіотензинперетворювального ферменту: можливості застосування в медицині та спортивній кардіології С. М. МалаховаМета роботи -формування сучасних уявлень про вплив поліморфізму гена ангіотензинперетворювального ферменту на функціонування різних систем організму, в тому числі у спортсменів. Матеріали та методи. Аналіз та узагальнення даних сучасної наукової літератури.Результати. Відповідно до сучасних уявлень молекулярної генетики спорту, індивідуальні відмінності у ступені вира-женості тих чи інших фізичних і психічних якостей людини багато в чому зумовлені ДНК-поліморфізмами. Виявлено особливості впливу I/D поліморфізму гена ангіотензинперетворювального ферменту на функціонування життєзабез-печувальних систем в осіб, які не займаються спортом. Цей поліморфізм доволі широко розкритий у професійних спортсменів із погляду можливості розвитку фізичних якостей, водночас недостатньо вивчені питання ризи...

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“…Gene polymorphisms predisposing to the development of hypertension have been described, the most important affecting the genes coding for angiotensinogen (AGT), angiotensin II receptor type 1 (AGTR1), angiotensin converting enzyme (ACE) and integrin beta 3 (ITGB3 -HPA-1) ( Table 3) [37,38].…”

Section: Risk Assessment Of Fatal Thromboembolic and Hypertensive Eventsmentioning

confidence: 99%

Personalized Medicine Applied to Forensic Sciences: New Advances and Perspectives for a Tailored Forensic Approach

Santurro

Vullo

Borro

et al. 2017

CPB

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Personalized medicine (PM), included in P5 medicine (Personalized, Predictive, Preventive, Participative and Precision medicine) is an innovative approach to the patient, emerging from the need to tailor and to fit the profile of each individual. PM promises to dramatically impact also on forensic sciences and justice system in ways we are only beginning to understand. The application of omics (genomic, transcriptomics, epigenetics/imprintomics, proteomic and metabolomics) is ever more fundamental in the so called "molecular autopsy". Emerging fields of interest in forensic pathology are represented by diagnosis and detection of predisposing conditions to fatal thromboembolic and hypertensive events, determination of genetic variants related to sudden death, such as congenital long QT syndromes, demonstration of lesions vitality, identification of biological matrices and species diagnosis of a forensic trace on crime scenes without destruction of the DNA. The aim of this paper is to describe the state-of-art in the application of personalized medicine in forensic sciences, to understand the possibilities of integration in routine investigation of these procedures with classical post-mortem studies and to underline the importance of these new updates in medical examiners' armamentarium in determining cause of death or contributing factors to death.

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Interaction of six candidate genes in essential hypertension

Cited by 10 publications

References 22 publications

Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption

Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption

Angiotensin-converting enzyme gene: application possibilities in medicine and sports cardiology (literature review)

Personalized Medicine Applied to Forensic Sciences: New Advances and Perspectives for a Tailored Forensic Approach

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