Interaction of signal transducer and activator of transcription 3 polymorphisms with hepatitis B virus mutations in hepatocellular carcinoma

Xie, Jun; Zhang, Yuwei; Zhang, Qi; Han, Yaling; Yin, Jianhua; Pu, Rui; Shen, Qiuxia; Lu, Wei; Du, Yan; Zhao, Jingbo; Han, Xue; Zhang, Hongwei; Cao, Guangwen

doi:10.1002/hep.26303

Cited by 55 publications

(87 citation statements)

References 37 publications

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“…Also in this study the mentioned polymorphism was associated with chronic hepatitis B infection and low viral load. Therefore, this polymorphism might be related to immunity tolerance (13). In the present study, the mean age of the participants in the healthy group was 35.86 years, in the chronic hepatitis B group was 40.04 years and in the HCC group was 53.78 years.…”

Section: Discussionmentioning

confidence: 44%

“…Also in this study the mentioned polymorphism was associated with chronic hepatitis B infection and low viral load. Therefore this polymorphism could be associated with immunity tolerance too (13). According to this study SNPrs1053004 could be a new genetic marker that its recognition might be helpful in the advancement of the disease in developing hepatocellular carcinoma among patients with chronic hepatitis B (13).…”

Section: Introduction *mentioning

confidence: 87%

“…Recently the polymorphisms of this protein in formation of cancer have been studied and some of these polymorphisms are SNPrs1053004 (T > C), rs4796793 (C > G), rs2293152 (C > G) and etc. This polymorphism itself is consisted of different alleles and genotypes including T alleles (thymine) and C alleles (cytosine) and these alleles have different forms of dominant and recessive (9)(10)(11)(12)(13)(14). Some studies have shown that STAT3 protein has a potential role in inflammation, survival, extension and invasion of hepatocyte cells and development of liver cancer (9,15).…”

Section: Introduction *mentioning

confidence: 99%

“…In another study, inhibition of STAT3 caused an average reduction in expression of hepatitis B virus and consequently development of hepatocellular carcinoma was prevented; this indicated the role of STAT3 in spreading cancer in liver cells (16,17). Another study has shown that one of the most important factors for phosphorylation and consequently activation of STAT3 protein, is the X protein from the hepatitis B virus, IL11, IL6 (interleukins are a group of secretory protein that are produced by different cells including leukocytes and are responsible for mediation and regulation of all the aspects of innate and adaptive immunity), NFKB and acute phase proteins, which by activating this protein would develop metastasis in the cell (13,18). In study that was conducted on rs1053004 polymorphism of H Study on the relationship of demographic characteristics of rs1053004 in STAT3 Gene... STAT3, a relation was revealed between this polymorphism and the increased risk of hepatocellular carcinoma; in this study the CC allele in comparison to the TT allele, and men compared to women, were significantly associated with higher risks of HCC.…”

Section: Introduction *mentioning

confidence: 99%

“…Therefore this polymorphism could be associated with immunity tolerance too (13). According to this study SNPrs1053004 could be a new genetic marker that its recognition might be helpful in the advancement of the disease in developing hepatocellular carcinoma among patients with chronic hepatitis B (13). Considering that liver cancer is the third cause of one of the deadliest gastrointestinal cancers (19,20), and also, since in Iran, cases of liver cancer are usually diagnosed at the intermediate or advanced stages of the cancer, it is necessary to find solutions for diagnosing the disease before these stages which will help to prevent its development and provide timely treatment (21).…”

Section: Introduction *mentioning

confidence: 99%

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Study on the relationship of demographic characteristics of rs1053004 in STAT3 Gene in pationts with HCC following chronic HBV infection

Fatemipour¹,

Zadeh²,

Molaei³

et al. 2016

Iran J Virol

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Background and Aims: Hepatocellular carcinoma (HCC) is one of the most important common cancers in the world. The main etiology of this cancer in developing and third world countries is due to the infection with hepatitis B and C viruses. Hepatitis B and C viruses (HCV) would both cause liver cancer but the incidence of the disease in relation to the age and gender has not been determined. The present study was conducted to evaluate the relation between some demographic characteristics with rs1053004 polymorphism in STAT3 gene among patients with liver cancer following chronic hepatitis B infection and its comparison with healthy subjects. Materials and Methods: In this study, 33 tissue samples of liver cancer from pationts with HBV infection, 50 blood samples from patients with chronic hepatitis B and 50 blood samples from healthy subjects, as the control group, were obtained to determine rs1053004 polymorphism in STAT3 gene (signal transducer factor and activator of transcription in the nucleus) using Real Time PCR method. Results: In the present study 133 subjects were evaluated and from them, 50 (37.6%) were healthy and 50 of the participants (37.6%) had chronic hepatitis B and 33 (24.8%) had HCC. 69.9% of the participants (93 participants) were male and 30.1% (40 participants) were female. According to the results, the gender of the participants in the studied groups had no significant relation with their SNPrs1053004 polymorphism. But the relation between gender and liver cancer was statistically significant (p < 0001); indicating that the prevalence of liver cancer was higher among men than women. The average age of the healthy group was 35.86 years, of the chronic hepatitis B group was 40.4 years and of the HCC group was 53.78 years. Based on the results, the difference in age groups of chronic hepatitis B group and HCC pationts was statistically significant as compared with the control group (p < 0.001). Conclusions:Results of the present study showed no significant relation between the presence of rs1053004 polymorphism in STAT3 gene (signal transducer factor and activator of transcription in the nucleus) and gender of the participants but the difference between the ages of the healthy group, chronic hepatitis B group and HCC group was statistically significant. In other words, age could be a predicting factor in developing HCC.

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Section: Discussionmentioning

confidence: 44%

Section: Introduction *mentioning

confidence: 87%

Section: Introduction *mentioning

confidence: 99%

Section: Introduction *mentioning

confidence: 99%

Section: Introduction *mentioning

confidence: 99%

See 3 more Smart Citations

Study on the relationship of demographic characteristics of rs1053004 in STAT3 Gene in pationts with HCC following chronic HBV infection

Fatemipour¹,

Zadeh²,

Molaei³

et al. 2016

Iran J Virol

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Hepatitis Viruses and Hepatoma

Wang¹,

Cao

et al. 2017

Holland‐Frei Cancer Medicine

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Overview Hepatitis is an inflammation of the liver, occurring as the result of a viral infection or the exposure of liver to toxic substances such as alcohol or aflatoxin B. Hepatitis viruses are the most common cause of hepatitis in the world, of which HBV and HCV can cause persistent liver infection, frequently resulting in chronic hepatitis, liver cirrhosis, and eventually hepatocellular carcinoma (HCC). HBV belongs to the genus Orthohepadnavirus of the Hepadnaviridae with a circular incomplete double‐stranded DNA genome, containing four overlapping open reading frames (ORFs) that encode the surface envelope protein (HBsAg), the core protein (HBcAg and HBeAg), a polymerase, and a multifunctional nonstructural protein termed X (HBx), respectively. HBV genotypes and subgenotypes have distinct geographical distributions. In East Asia, HBV genotypes B and C are endemic. Accordingly, any differences in its global incidence may be explained by differences in the HCV and HBV prevalence. It has been estimated that 57% of cirrhosis is attributable to either HBV (30%) or HCV (27%) and 78% of HCC is attributable to HBV (53%) or HCV (25%). In China, up to 80% of HCC cases are attributable to HBV, and approximately 20% of HCC patients test positive for HCV‐RNA. Besides the oncogenic function of HBV‐encoding protein, the HBV infection‐induced virus or host DNA mutation has been found contribution for HCC development. Unlike to HBV, HCV belongs to the genus Hepacivirus of the Flaviviridae family, with a single‐stranded positive‐sense RNA genome. There is no host genome integration, nor does HCV contain any known oncogenes. The major mechanisms of HCV‐induced hepatocarcinogenesis include the oncogenic effect of HCV viral proteins, steatosis and insulin resistance, chronic inflammation and fibrosis, oxidative stress, and chromosomal instability. This chapter exclusively focuses on hepatitis and hepatoma caused mainly by HBV and HCV infection, discussing epidemiologic considerations, construction and genotype, role of virus in performing HCC, and early diagnosis and prophylaxis. Still, viruses that selectively infect endemic host predispose patients to malignant hepatoma, to some extent, placing a burden on the healthcare worldwide. Therefore, an upturn in morbidity of hepatitis and hepatoma will be of great importance in public health.

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Hepatitis Viruses and Hepatoma

Wang

2022

Holland‐Frei Cancer Medicine

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Overview Hepatitis is inflammation of the liver, typically the result of virus infections or the exposure of the liver to toxic substances such as alcohol or aflatoxin B. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common causes of transient and persistent liver infections, frequently resulting in hepatitis and, in the context of chronic infections, liver cirrhosis, and hepatocellular carcinoma (HCC). Hepatitis B may be worsened by super or co‐infection with hepatitis delta virus, a subviral satellite.

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Interaction of signal transducer and activator of transcription 3 polymorphisms with hepatitis B virus mutations in hepatocellular carcinoma

Cited by 55 publications

References 37 publications

Study on the relationship of demographic characteristics of rs1053004 in STAT3 Gene in pationts with HCC following chronic HBV infection

Study on the relationship of demographic characteristics of rs1053004 in STAT3 Gene in pationts with HCC following chronic HBV infection

Hepatitis Viruses and Hepatoma

Hepatitis Viruses and Hepatoma

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