Interaction of [Ru(η6-p-cym)(H2O)3]2+ with citrate and tricarballate ions in aqueous solution; X-ray crystal structure of novel half-sandwich Ru(II)-citrato complexes

[(η6-p-cymene)Ru(H2O)3]2+ binding capability of aminohydroxamates — A solution and solid state study

“…Earlier studies mostly dealt with the design, synthesis, characterization and biological test of these [(η 6 -arene)Ru(XY)Z] type (arene = benzene(derivative), XY = chelating, Z = monodentate ligand) complexes. [6][7][8][9][10] Recent years research focusing on their solution behaviour or the interaction with various high [11][12][13][14][15][16][17] or low molecular mass [18][19][20][21][22][23][24][25][26][27][28][29] biomolecules is also in progress.…”

Complex Formation between [(η6‐p‐cymene)Ru(H2O)3]2+ and Hydroxycarboxylates or their Sulfur Analogues – The Role of Thiolate Groups in Metal Ion Binding

“…These findings suggest that the conformation of the mal 2– ligand is very similar in [RuA] and [RuAH –1 ] – , which are present in this pH range according to the potentiometric results. The configurations of these complexes with [COO – , COO – , OH] or [COO – , COO – , O – ] coordination are likely similar to that of [(η 6 ‐ p ‐cym)Ru(Hcitr)] (Figure 4, c), the X‐ray structure of which is known 7. These binding modes for the mal 2– complexes are also confirmed by the 1 H NMR spectroscopy results, specifically, the 3 J BX value for [RuAH –1 ] – under basic conditions (1.8 Hz) is much smaller than 3 J BX for the deprotonated ligand (10.1 Hz).…”

“… Newman projections for (a) the free malate, (b) the possible structure of [(η 6 ‐ p ‐cym)Ru(malH –1 )] – , and (c) [(η 6 ‐ p ‐cym)Ru(citrH)] (based on its X‐ray structure) 7…”

“…We found that the bidentate oxalate and lactate ligands bind to the metal ion in acidic medium but they are not able to hinder the hydrolysis of [(η 6 ‐ p ‐cym)Ru(H 2 O) 3 ] 2+ under physiologically relevant conditions 6. On the contrary, with the tridentate citrate ligand, one of the most‐studied low‐molecular‐weight serum components, a strong interaction was found even above pH 7.4 owing to the formation of [COO – , COO – , O – ] (6+5) joined chelates 7…”

Half-sandwich complexes of ruthenium, osmium, rhodium and iridium with dl-methionine or S-methyl-l-cysteine: a solid state and solution equilibrium study

“…-citr-ise-met 1 : 1 : 1 : 1 system, as a function of pH, using the previously determined log b values 7,9 and the data in Table 2, is calculated and shown in Fig. S3.…”