1984
DOI: 10.1677/joe.0.1020329
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Interaction of prostaglandin E2 and β-adrenergic catecholamines in the regulation of uterine smooth muscle motility and adenylate cyclase in the rat

Abstract: Prostaglandin E2 (PGE2) increased the force of the spontaneous contractions of the rat myometrium and decreased the sensitivity of the uterus to the relaxing effects of the specific beta-adrenergic catecholamine agonist isoprenaline. Prostaglandin E2, at concentrations above 10 mumol/l, increased cyclic AMP production by intact muscle strips. The muscle strips were far more sensitive, however, to the inhibitory effect PGE2 had on isoprenaline-dependent cyclic AMP production (threshold less than 0.001 nmol/l). … Show more

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Cited by 41 publications
(8 citation statements)
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(14 reference statements)
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“…In the current study the C-terminal domain of the G scoupled I1EP4R was not able to shift the Gj-coupled rEP 3 ßR to a G s -coupled receptor or to confer an additional G s coupling. In contrast, the chimeric rEP 3 hEP 4 R not only retained its rEP 3 ßR binding profile but also its Gj coupling properties.…”
Section: Role Of the C-terminal Domaincontrasting
confidence: 66%
See 1 more Smart Citation
“…In the current study the C-terminal domain of the G scoupled I1EP4R was not able to shift the Gj-coupled rEP 3 ßR to a G s -coupled receptor or to confer an additional G s coupling. In contrast, the chimeric rEP 3 hEP 4 R not only retained its rEP 3 ßR binding profile but also its Gj coupling properties.…”
Section: Role Of the C-terminal Domaincontrasting
confidence: 66%
“…Prostaglandin E2 (PGE 2 ) is a potent mediator of physiological and pathophysiological events in the body, for example stimulation of neurotransmitter release, regulation of the immune system and uterus contraction [1][2][3]. Its actions are mediated by binding to specific PGE2 ectoreceptors (EPR), »Corresponding author.…”
Section: Introductionmentioning
confidence: 99%
“…PGE receptors are pharmacologically subdivided into four subtypes, EP1, EP2, EP3, and EP4, on the basis of their responses to various agonists and antagonists [2,3]. Among these subtypes, the EP3 receptor has been best characterized; it has been suggested to be involved in such PGE2 actions as contraction of the uterus [4], inhibition of gastric acid secretion [5], modulation of the neurotransmitter release [6], lipolysis in adipose tissue [7], and sodium and water reabsorption in the kidney tubules [8]. Various EP3 receptor-mediated actions are mediated through multiple signal transduction systems, and in addition, the doseresponse curve and potency of PGE2 vary with tissue, implying heterogeneity of EP3 receptors [9,10].…”
Section: Introductionmentioning
confidence: 99%
“…Those studies contributed to an explanation of the PG production mechanism in the CNS, whereas histochemical approaches to the PGE receptors have almost never been performed. Among the PGE receptor subtypes, the EP3 receptor (EP3R) has been the best characterized and has been reported to be involved in contraction of the uterus (Krall et al, 1984), inhibition of gastric acid secretion (Chen et al, 1988), lipolysis in the adipose tissue (Richelsen and Beck-Nielsen, 1984), and sodium and water reabsorption in the kidney tubules (Garcia-Perez and Smith, 1984). These various actions of EP3R have been thought to be induced by inhibition of adenylate cyclase or stimulation of Ca 2ϩ mobilization (Negishi et al, 1995).…”
mentioning
confidence: 99%