Interaction of polyelectrolyte-shell cubosomes with serum albumin for triggering drug release in gastrointestinal cancer

Abstract

Nano-structured and functionalized materials for encapsulation, transport, targeting and controlled release of drugs are of high interest to overcome low bioavailability in oral administration. We develop lipid-based cubosomes, which are...

Flavonoid-Labeled Biopolymer in the Structure of Lipid Membranes to Improve the Applicability of Antioxidant Nanovesicles

“…This result is expected, considering that the assembly of the cubic network incorporates a relatively large macromolecule. A similar result has been previously described for multilamellar liposomes modified with chitosan [16], lipid-chitosan hydrogel [19] and for cubosomes tailored with biopolymers [20]. Secondly, for the hybrid lipid-biopolymer phase, a decreased for the oxidation-challenged samples.…”

“…Secondly, for the hybrid lipid–biopolymer phase, a decreased for the oxidation-challenged samples. Hence, despite the absence of a phase transition, the reduction in a for the samples with chitosan–catechin denotes an additional structural effect of the oxidative media, which may be related to the lower extent of lipid oxidation and/or the dehydration of the crystalline network, i.e., a reduction in the water labyrinths [ 20 , 51 ]. Although, this structural change is notably to a lesser extent when compared to the phase transition to the H II phase that occurred in absence of the biopolymer.…”

“…In addition, giant vesicles containing chitosan have been produced by a modification of the known electroformation method, thus allowing the incorporation of the polysaccharide over the lipidic membrane [ 18 ]. More recently, studies reporting the inclusion of chitosan and a chitosan derivative in liquid crystalline bicontinuous cubic phases and cubosomes have evidenced the potential of the polysaccharide in providing specific characteristics to the nanoparticles for improvement in bioactive delivery applications [ 19 , 20 ].…”

Vitexin‐loaded poly(ethylene glycol) methyl ether‐grafted chitosan/alginate nanoparticles: preparation, physicochemical properties and in vitro release behaviors

“…While the preparation of chitosan/ALG nanoparticles for encapsulating and controlling the release of bioactive compounds has been reported for many years, most methods required crosslinkers, particularly sodium tripolyphosphate 23‐25 and calcium chloride, 19,24,26 to harden the nanoparticles and to control the bioactive agents' release rate. Few studies have examined nanoparticles formed from polyelectrolyte complexes between polycationic chitosan and polyanionic ALG for encapsulating bioactive compounds such as crocin, 27 bovine serum albumin 28 and nerolidol, 18 and functionalizing lipid‐based nanocarriers toward improved delivery in various applications 29,30 . However, their preparation requires weak acids with pungent odors, such as acetic or formic acid, to dissolve and provide positive charges for chitosan before complexation with ALG, limiting their broad application.…”

“…Few studies have examined nanoparticles formed from polyelectrolyte complexes between polycationic chitosan and polyanionic ALG for encapsulating bioactive compounds such as crocin, 27 bovine serum albumin 28 and nerolidol, 18 and functionalizing lipid-based nanocarriers toward improved delivery in various applications. 29,30 However, their preparation requires weak acids with pungent odors, such as acetic or formic acid, to dissolve and provide positive charges for chitosan before complexation with ALG, limiting their broad application.…”