Interaction of Polyanion Against Kanamycin Ototoxicity

Saitô, Hitoshi; Uede, Kazuo; Saito, Takehisa; Oshima, Wataru; Komiya, Seiichi; Ono, Toshiyuki; Shida, Susumu

doi:10.1016/s0385-8146(87)80014-7

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Protection Against Aminoglycoside Ototoxicity1

Genetics and Ototoxicity1

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1995

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Cited by 2 publications

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“…Many attempts at developing means of protection against aminoglycoside ototoxicity have been made on the basis of facts or hypotheses. For instance, several anionic agents have been tried, in view of their combination with the cationic aminoglycoside macromolecules, 59 , 60 with variable success 61 . Agents protecting against nephrotoxicity have also been tested.…”

Section: Protection Against Aminoglycoside Ototoxicitymentioning

confidence: 99%

“…For instance, several anionic agents have been tried, in view of their combination with the cationic aminoglycoside macromolecules, 59,6° with variable success. 61 Agents protecting against nephrotoxicity have also been tested. This was the case recently for poly-L-aspartic acid (PLAA), which was demonstrated both in vivo and in vitro to be effective in reducing GM nephrotoxicity.…”

Section: Genetics and Ototoxicitymentioning

confidence: 99%

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