“…For instance, several anionic agents have been tried, in view of their combination with the cationic aminoglycoside macromolecules, 59,6° with variable success. 61 Agents protecting against nephrotoxicity have also been tested. This was the case recently for poly-L-aspartic acid (PLAA), which was demonstrated both in vivo and in vitro to be effective in reducing GM nephrotoxicity.…”