Interaction of Platelets with Ascitic Plasmacytoma <i>in vitro</i>

Abstract

During interaction in vitro of syngenic platelets from healthy mice with HIPA ascitic plasmacytoma, clot formation was slower than during interaction of syngenic platelets from HIPA tumor-bearing mice with HIPA plasmacytoma. The platelet aggregates were composed, in both cases, of ‘balloon platelets’ and tumor cells. The granulated part of the ‘balloon platelets’ made up the centre, whereas granule-free spheroids were seen at the periphery of the aggregates. To contact with platelets, the tumor cells reacted with formation of microvilli, condensation of mitochondria and phagocytosis of the granule-free spheroids. No formation of pseudopodia by platelets in contact with the tumor cells was observed.