Interaction of Platelet-Rich Concentrate With Bone Graft Materials: An In Vitro Study

Butcher, Andrew; Milner, Richard; Ellis, K. O.; Watson, John T.; Hörner, A.

doi:10.1097/bot.0b013e31819b35db

Cited by 16 publications

(9 citation statements)

References 25 publications

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“…Butcher et al found a signifi cant increase in DNA content and mineralization level by adding PRP to DBM in vitro. 67 Likewise, a viable osteochondral construct has been created with DBM and PRP ex vivo. 249 In contrast, Ranly et al found a neutral or even inhibitory eff ect of PRP to the ectopic formation of bone induced by DBM in a nude mouse model.…”

Section: Discussionmentioning

confidence: 99%

Treatment of osteochondral defects of the talus

Bergen

Leeuw

Dijk

2008

Revue de Chirurgie Orthopédique et Réparatrice de l'Appareil Mo

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Section: Discussionmentioning

confidence: 99%

Treatment of osteochondral defects of the talus

Bergen

Leeuw

Dijk

2008

Revue de Chirurgie Orthopédique et Réparatrice de l'Appareil Mo

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“…The basis for the thyroid surgery was founded by Theodor Billroth and Theodor Kocher, between 1873 and 1893, that standardized and precise anatomical dissection with preliminary ligation of the two principal arteries of the gland on each side, followed by excision of the gland[1]. …”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of thyroidectomy with ultrasonic dissector versus conventional clamp and tie

et al. 2010

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BackgroundWe conducted a systematic review to evaluate the role of Ultrasonic dissector (UAS) versus conventional clamp and tie in thyroidectomy.Materials and methodsWe searched for all published RCT in into electronic databases. To be included in the analysis, the studies had to compare thyroidectomy with UAS versus conventional vessel ligation and tight (conventional technique = CT). The following outcomes were used to compare the total thyroidectomy group with UAS versus CT group: operative duration, operative blood loss, overall drainage volume during the first 24 hours, transiet laryngeal nerve palsy, permanent laryngeal nerve palsy, transiet hypocalcaemia and permanent hypocalcaemia.ResultsThere are currently 7 RCT on this issue to compare thyroidectomy with UAS versus CT. From the analysis of these studies it was possible to confront 608 cases: 303 undergoing to thyroidectomy with UAS versus 305 that were treated with CT. Actually, it was shown a relevant advantage of cost-effectiveness in patients treated with UAS; there is a statistically significant reduction of the operative duration (weighted mean difference [WMD], -18.74 minutes; 95% confidence interval [CI], (-26.97 to -10.52 minutes) (P = 0.00001), intraoperative blood loss (WMD, -60.10 mL; 95% CI, -117.04 to 3.16 mL) (P = 0.04) and overall drainage volume (WMD, -35.30 mL; 95% CI, -49.24 to 21.36 mL) (P = 0.00001) in the patients underwent thyroidectomy with UAS. Although the analysis showed that the patients who were treated with USA presented more favourable results in incidence of post-operative complications (transient laryngeal nerve palsy: P = 0.11; permanent laryngeal nerve palsy: not estimable; transient hypocalcaemia: P = 0.24; permanent hypocalcaemia: P = 0.45), these data didn't present statistical relevance.ConclusionThis meta-analysis shown a relevant advantage only in terms of cost-effectiveness in patients treated with UAS; it is subsequent to statistically significant reduction of operation duration, intraoperative blood loss and of overall drainage volume during the first 24 hours. Although the analysis showed that the patients who were treated with UAS presented more favourable results in incidence of post-operative complications (transiet laryngeal nerve palsy; transiet hypocalcaemia and permanent hypocalcaemia), these data didn't present statistical relevance.

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“…Pieske et al demonstrated in their clinical study, using autologous bone graft versus DBM in the internal fixation of ununited long bones that the application of DBM compared to iliac crest autologous bone grafting led to a better outcome and simultaneously to a decreased quantity of adverse effects [116]. The combination of DBM and PRP increases the proliferation of human bone marrow stromal cells (hBMSC), as well as the osteoblastic differentiation and bone formation compared with PRP alone [117] or DBM alone [118]. …”

Section: Methodsmentioning

confidence: 99%

The Use of Platelet Rich Plasma, Bone Morphogenetic Protein-2 and Different Scaffolds in Oral and Maxillofacial Surgery - Literature Review in Comparison with Own Clinical Experience

Schuckert¹,

Jopp²,

Osadnik³

2011

JOMR

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ObjectivesThe purpose of this article was to review and critically assess the use of platelet rich plasma, recombinant human bone morphogenetic protein-2 and different scaffolds (i.e. tricalciumphosphate, polycaprolactone, demineralized bone matrix and anorganic bovine bone mineral) in oral and maxillofacial surgery comparing the relevant literature and own clinical experience.Material and MethodsA literature review was conducted using MEDLINE, MEDPILOT and COCHRANE DATABASE OF SYSTEMATIC REVIEWS. It concentrated on manuscripts and overviews published in the last five years (2006-2010). The key terms employed were platelet rich plasma, bone morphogenetic proteins and their combinations with the above mentioned scaffolds. The results of clinical studies and animal trials were especially emphasized. The statements from the literature were compared with authors’ own clinical data.ResultsNew publications and overviews demonstrate the advantages of platelet rich plasma in bone regeneration. The results from the literature review were discussed and compared with the publications detailing authors' own experiences.ConclusionsA favourable outcome concerning newly grown bone was achieved combining platelet rich plasma in addition to optimal matrices with or without recombinant human bone morphogenetic protein-2, depending on the clinical case. As a consequence, the paradigm shift from transplantation of autogenous bone to bone tissue engineering appears promising.

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Interaction of Platelet-Rich Concentrate With Bone Graft Materials: An In Vitro Study

Cited by 16 publications

References 25 publications

Treatment of osteochondral defects of the talus

Treatment of osteochondral defects of the talus

Meta-analysis of thyroidectomy with ultrasonic dissector versus conventional clamp and tie

The Use of Platelet Rich Plasma, Bone Morphogenetic Protein-2 and Different Scaffolds in Oral and Maxillofacial Surgery - Literature Review in Comparison with Own Clinical Experience

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