“…In PoPc and DPc, most CSPs occurred around the regions with the acidic patches, in agreement with the assumption that the positively charged peptides interact with the acidic residues of Pc. [20,33] The largest CSPs for PoPc occurred for residues Asp44, Ser45, Asp51, Ile55, and Gln88. Among these residues, Asp44 belongs to the acidic patch.…”