Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape

Seider, Katja; Heyken, Antje; Lüttich, Anja; Miramón, Pedro; Hube, Bernhard

doi:10.1016/j.mib.2010.05.001

Cited by 148 publications

(130 citation statements)

References 77 publications

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“…neoformans, and C. albicans (reviewed in Refs. 14,15). In this study, we discovered that C. glabrata controls the process of phagosome maturation and acidification in human primary macrophages at a distinct stage.…”

Section: Glabrata Blocks Phagolysosome Formation and Phagosome Acimentioning

confidence: 83%

“…Furthermore, phagocytic cells act as immune modulators by presenting Ags and secreting pro-and anti-inflammatory cytokines and chemokines, recruiting further immune cells and activating the adaptive arm of the immune system. Nevertheless, pathogenic microbes have evolved strategies to counteract the phagocytic attack and to overcome killing by immune cells (14,15). Many bacterial pathogens have been studied with great success; far less, however, is known about facultative intracellular fungi.…”

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confidence: 99%

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The Facultative Intracellular Pathogen Candida glabrata Subverts Macrophage Cytokine Production and Phagolysosome Maturation

Seider

Brunke

Schild

et al. 2011

The Journal of Immunology

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184

226

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Although Candida glabrata is an important human pathogenic yeast, its pathogenicity mechanisms are largely unknown. Immune evasion strategies seem to play key roles during infection, since very little inflammation is observed in mouse models. Furthermore, C. glabrata multiplies intracellularly after engulfment by macrophages. In this study, we sought to identify the strategies that enable C. glabrata to survive phagosome biogenesis and antimicrobial activities within human monocyte-derived macrophages. We show that, despite significant intracellular proliferation, macrophage damage or apoptosis was not apparent, and production of reactive oxygen species was inhibited. Additionally, with the exception of GM-CSF, levels of pro- and anti-inflammatory cytokines were only marginally increased. We demonstrate that adhesion to and internalization by macrophages occur within minutes, and recruitment of endosomal early endosomal Ag 1 and lysosomal-associated membrane protein 1 indicates phagosome maturation. However, phagosomes containing viable C. glabrata, but not heat-killed yeasts, failed to recruit cathepsin D and were only weakly acidified. This inhibition of acidification did not require fungal viability, but it had a heat-sensitive surface attribute. Therefore, C. glabrata modifies the phagosome into a nonacidified environment and multiplies until the host cells finally lyse and release the fungi. Our results suggest persistence of C. glabrata within macrophages as a possible immune evasion strategy.

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Section: Glabrata Blocks Phagolysosome Formation and Phagosome Acimentioning

confidence: 83%

mentioning

confidence: 99%

The Facultative Intracellular Pathogen Candida glabrata Subverts Macrophage Cytokine Production and Phagolysosome Maturation

Seider

Brunke

Schild

et al. 2011

The Journal of Immunology

Self Cite

184

226

View full text Add to dashboard Cite

show abstract

“…For example, in B. dermatitidis, H. capsulatum, and P. brasiliensis, the transition from the hyphal to the pathogenic yeast form is accompanied by increased a-1,3-glucan deposition in the cell wall (Kanetsuna and Carbonell 1971;Seider et al 2010), which masks the immunostimulatory b-glucan (Rappleye et al 2007). Additionally, these different fungal morphotypes can display altered tolerance of certain host physiological conditions, as well as varying abilities to disseminate in different host tissues (Klein and Tebbets 2007).…”

Section: Morphotype Niche Adaptation and Fungal Virulencementioning

confidence: 99%

Fungal Morphogenesis

Lin

Alspaugh

Liu

et al. 2014

Cold Spring Harbor Perspectives in Medicine

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Morphogenesis in fungi is often induced by extracellular factors and executed by fungal genetic factors. Cell surface changes and alterations of the microenvironment often accompany morphogenetic changes in fungi. In this review, we will first discuss the general traits of yeast and hyphal morphotypes and how morphogenesis affects development and adaptation by fungi to their native niches, including host niches. Then we will focus on the molecular machinery responsible for the two most fundamental growth forms, yeast and hyphae. Last, we will describe how fungi incorporate exogenous environmental and host signals together with genetic factors to determine their morphotype and how morphogenesis, in turn, shapes the fungal microenvironment. PROPERTIES OF MORPHOGENESIS IN FUNGAL CELLS

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“…are the most common cause of fungal infection in immune compromised persons known as Candidiasis, predominantly caused by C.albicans, they may be detected in 40 to 65% of normal fecal flora, C.albicans can infect all areas of the skin as well as the mucous membranes [30]. Germ-tube formation is a virulence factor for C.albicans and also is a good tool for identification this species [31]. High production of Germ tube among the C.albicans isolates in the current study refer to the pathogenicity of these isolates.…”

Section: Resultsmentioning

confidence: 99%

Determination of some virulence factors of Candida spp. isolated from locally produced cheese in Diyala Governorate-Iraq

Fadihl

2017

MJS

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Locally produced cheese which called (Gibin Al arab) is one of the most common dairy products in Iraq, it has an economic importance and great social value. This research aimed to identify yeast species from locally produced cheese (Gibin Al Arab) in Diyala city which traditionally made and sold in markets of old town in Baquba, and study some of virulence factors (Esterase production, Phospholipase and Hemolytic production) of yeasts belong to genus of Candida . All cheese samples showed contamination with varying number of yeast, total 88 yeast isolates obtained from 70 cheese samples, they were Geotrichum candidum(20.5%), Rhodotorela species(19.4%), Candida parapsilosis (18%), Candida albicans (13.6%), Candida tropicalis (10.5%), Candida krusei (8%), Saccharomyces cerevisice (3.3%) and mixed yeast (un identified) at rate of (6.7%). Species of Candida formed half of the total isolates and the most prevalent isolate of Candida spp. was Candida parapsilosis .According to the results determining of (Esterase production, Phospholipase and Hemolytic production) as a virulence factors identifying Candida spp. these activities referred that all isolates of Candida spp. show one or more of these activities and that isolates of medically important species Candida albicans were the most virulent isolates. this referred to the importance of take attention about consuming of such types of dairy products and need for applying more hygienic measures during handling, processing of milk and form of storage and/or selling of cheese . ‫الخالصة‬ ‫وثقافية‬ ‫اجتماعية‬ ‫قيمــة‬ ‫من‬ ‫لــه‬ ‫لمــا‬ ‫العراق‬ ‫في‬ ‫شيوعـا‬ ‫الحليب‬ ‫منتجات‬ ‫اكثر‬ ‫احـد‬ ‫محليا‬ ‫المصنع‬ ‫العرب‬ ‫جبن‬

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Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape

Cited by 148 publications

References 77 publications

The Facultative Intracellular Pathogen Candida glabrata Subverts Macrophage Cytokine Production and Phagolysosome Maturation

The Facultative Intracellular Pathogen Candida glabrata Subverts Macrophage Cytokine Production and Phagolysosome Maturation

Fungal Morphogenesis

Determination of some virulence factors of Candida spp. isolated from locally produced cheese in Diyala Governorate-Iraq

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