Interaction of p-cymene with β-cyclodextrin

Serafini, Mairim Russo; Menezes, Paula P.; Costa, Luiz Pereira da; Lima, Cláudio Moreira; Cardoso, Juliana Cordeiro; Matos, J. R.; Sobrinho, José Lamartine Soares; Grangeiro, Severino; Nunes, Paula Santos; Bonjadim, L. R.; Araújo, Adriano A. S.

doi:10.1007/s10973-011-1736-x

Cited by 61 publications

(28 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For pure CDs, the bands at 3296 and 3310 cm −1 represent symmetric and asymmetric O–H stretching due to the intermolecular hydrogen bonds of methyl β‐CD and hydroxypropyl β‐CD, respectively, while bands at 2858 and 2925 cm −1 are related to the C–H stretch. The absorption bands at 1646 and 1645 cm −1 correspond to H–O–H bending, while the bands at 1154 and 1076 cm −1 are assigned to the asymmetric and symmetric C–O–C stretching vibrations, respectively . The FTIR spectra of the inclusion complexes showed CD vibrational peaks similar to those of pure CD and all the absorption bands of the guest TM.…”

Section: Resultsmentioning

confidence: 89%

Preparation and characterization of chitosan based hydrogels containing cyclodextrin inclusion compounds or nanoemulsions of thyme oil

Moradi

Barati

Salehi

et al. 2019

Polymer International

View full text Add to dashboard Cite

Hydrogels derived from natural polysaccharides are ideal scaffolds for use in biomedical applications. pH‐sensitive polyvinyl alcohol and chitosan hydrogels containing inclusion compounds of thyme oil (TM) with host methyl‐β‐cyclodextrin (MβCD) and hydroxypropyl‐β‐cyclodextrin (HβCD) and TM nanoemulsion (TM‐nano) were prepared via controlled, biocompatible and low cost freeze–thaw method. The structure of the hydrogels was characterized by Fourier transform IR spectroscopy and optical and scanning electron microscopy. The physicochemical properties of the hydrogels such as gel fraction, swelling ratio and tensile properties were measured. The water vapor transmission rate of the hydrogels indicated that they can maintain a moist environment over the wound bed. Encapsulation and release of antibacterial TM from the hydrogels were determined by UV spectroscopy. In all cases, hydrogels with lower amounts of TM evidenced slower and more controlled release. Different kinetic models were applied for evaluating the drug release mechanism. The antibacterial activity of the samples was studied by counting the number of both Gram‐negative and Gram‐positive bacteria surviving in a broth medium and the results proved the antibacterial activity of all prepared hydrogels. The results of an MTT (3‐(4,5‐dimethylthiazol‐2yl)‐2,5‐diphenyltetrazolium bromide) assay indicated more cell viability of TM‐nano hydrogels in comparison with those of TM‐βCD inclusion compounds. Cell attachment observations also showed great biocompatibility of TM‐nano hydrogels. The prepared hydrogels, especially those containing TM‐nano, might be used as potential wound dressings to improve the wound healing process. © 2019 Society of Chemical Industry

show abstract

Section: Resultsmentioning

confidence: 89%

Preparation and characterization of chitosan based hydrogels containing cyclodextrin inclusion compounds or nanoemulsions of thyme oil

Moradi

Barati

Salehi

et al. 2019

Polymer International

View full text Add to dashboard Cite

show abstract

“…The structures of the drugs are shown in figure 1. In his article, we report the drug-drug interactions of some commonly used drugs that are frequently prescribed in Bangladesh for the benefits of the patients by using DSC and HPLC, which are most commonly used to determine the drug-drug interactions (Pignatello and Francesco, 2011;Serafini et al, 2012;Arayne et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Studies of Interactions of Valsartan, Glimepiride and Ciprofloxacin HCl by DSC and HPLC

et al. 2018

View full text Add to dashboard Cite

This article deals with the results of in vitro interactions among glimepiride, ciprofloxacin HCl and valsartan at the molar ratio of 1:1:1 by DSC and HPLC method. The DSC thermogram of the mixture (glimepiride, ciprofloxacin HCl and valsartan) showed different melting endotherm than the melting endotherm for standard valsartan, ciprofloxacin HCl and glimepiride. Since the melting endotherms of mixture and individual drugs were not identical, it demonstrated the presence of interactions among the drugs. This result was further verified by HPLC to observe their recovery range. The % recovery ranges were found as 25.33, 23.49 and 135.82% for glimepiride, ciprofloxacin HCl and valsartan, respectively. The abnormal percentage recovery range and peak areas fluctuation further indicated the interactions among glimepiride, ciprofloxacin HCl and valsartan.

show abstract

“…Natural or chemically modified cyclodextrins (cyclic oligosaccharides with hydrophobic inner cavities and hydrosolubilizing outer groups) are widely used for protection, enhancing water solubility, and controlled release properties of bioactive compounds [28-34]. The aqueous solubility of metallocenes ( i.e.…”

Section: Introductionmentioning

confidence: 99%

Titanocene / cyclodextrin supramolecular systems: a theoretical approach

Riviş

Hădărugă

Gârban

et al. 2012

Chemistry Central Journal

View full text Add to dashboard Cite

BackgroundRecently, various metallocenes were synthesized and analyzed by biological activity point of view (such as antiproliferative properties): ruthenocenes, cobaltoceniums, titanocenes, zirconocenes, vanadocenes, niobocenes, molibdocenes etc. Two main disadvantages of metallocenes are the poor hydrosolubility and the hydrolytic instability. These problems could be resolved in two ways: synthetically modifying the structure or finding new formulations with enhanced properties. The aqueous solubility of metallocenes with cytostatic activities could be enhanced by molecular encapsulation in cyclodextrins, as well as the hydrolytic instability of these compounds could be reduced.ResultsThis study presents a theoretical approach on the nanoencapsulation of a series of titanocenes with cytotoxic activity in α-, β-, and γ-cyclodextrin. The HyperChem 5.11 package was used for building and molecular modelling of titanocene and cyclodextrin structures, as well as for titanocene/cyclodextrin complex optimization. For titanocene/cyclodextrin complex optimization experiments, the titanocene and cyclodextrin structures in minimal energy conformations were set up at various distances and positions between molecules (molecular mechanics functionality, MM+). The best interaction between titanocene structures and cyclodextrins was obtained in the case of β- and γ-cyclodextrin, having the hydrophobic moieties oriented to the secondary face of cyclodextrin. The hydrophobicity of titanocenes (logP) correlate with the titanocene-cyclodextrin interaction parameters, especially with the titanocene-cyclodextrin interaction energy; the compatible geometry and the interaction energy denote that the titanocene/β- and γ-cyclodextrin complex can be achieved. Valuable quantitative structure-activity relationships (QSARs) were also obtained in the titanocene class by using the same logP as the main parameter for the in vitro cytotoxic activity against HeLa, K562, and Fem-x cell lines.ConclusionsAccording to our theoretical study, the titanocene/cyclodextrin inclusion compounds can be obtained (high interaction energy; the encapsulation is energetically favourable). Further, the most hydrophobic compounds are better encapsulated in β- and γ-cyclodextrin molecules and are more stable (from energetically point of view) in comparison with α-cyclodextrin case. This study suggests that the titanocene / β- and γ-cyclodextrin complexes (or synthetically modified cyclodextrins with higher water solubility) could be experimentally synthesized and could have enhanced cytotoxic activity and even lower toxicity.

show abstract

Interaction of p-cymene with β-cyclodextrin

Cited by 61 publications

References 19 publications

Preparation and characterization of chitosan based hydrogels containing cyclodextrin inclusion compounds or nanoemulsions of thyme oil

Preparation and characterization of chitosan based hydrogels containing cyclodextrin inclusion compounds or nanoemulsions of thyme oil

Studies of Interactions of Valsartan, Glimepiride and Ciprofloxacin HCl by DSC and HPLC

Titanocene / cyclodextrin supramolecular systems: a theoretical approach

Contact Info

Product

Resources

About