Interaction of ouabain and diphenylhydantoin (DPH) with the cardiovascular actions of prostaglandin B2 and prostaglandin A2

Enhancement of Neural and Thermal Vasoconstriction by Prostaglandin B1

“…It was suggested that the ability of PGB2 to enhance thermal and neurogenic vasoconstriction resulted from a selective ability of PGB compounds to facilitate catecholamine release. However, the possibility that these effects of PGB, were secondary to the increased wall stress resulting from the higher distending pressure could not be entirely eliminated (1)(2)(3).…”

“…Prostaglandin B1 (PGB1) is less potent a constrictor of the canine paw than is PGB2 and possesses intrinsic vasodilator properties at low concentrations (1)(2)(3). This study examines the effects of PGBl on the responses of the perfused canine paw to local cooling and heating to evaluate whether the effects of PGB compounds on these interventions are intrinsic to the prostaglandin B molecule or reflect the increased wall stress and transmural pressure associated with the constricted paw.…”