Interaction of organic compounds and boron clusters with new silica matrices containing the phosphatidylcholine headgroup

Fan, Ping; Stolte, Stefan; Gabel, Detlef

doi:10.1039/c4ay00119b

Cited by 10 publications

(6 citation statements)

References 21 publications

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“…It is interpreted by the fact that dodecaborate act as hydrophilic but superchaotropic anion in water solution. 30,[44][45][46][47] It means that water is less structured and more "lipophilic" around such anions as compared to bulk water. Association of chaotropes with cyclodextrins is explained not in terms of hydrophobic action but as so-called chaotropic effect because it is enthalpy driven.…”

Section: Introductionmentioning

confidence: 98%

Stealth Amphiphiles: Self-Assembly of Polyhedral Boron Clusters

et al. 2016

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This is the first experimental evidence that both self-assembly and surface activity are common features of all water-soluble boron cluster compounds. The solution behavior of anionic polyhedral boranes (sodium decaborate, sodium dodecaborate, and sodium mercaptododecaborate), carboranes (potassium 1-carba-dodecaborate), and metallacarboranes {sodium [cobalt bis(1,2-dicarbollide)]} was extensively studied, and it is evident that all the anionic boron clusters form multimolecular aggregates in water. However, the mechanism of aggregation is dependent on size and polarity. The series of studied clusters spans from a small hydrophilic decaborate-resembling hydrotrope to a bulky hydrophobic cobalt bis(dicarbollide) behaving like a classical surfactant. Despite their pristine structure resembling Platonic solids, the nature of anionic boron cluster compounds is inherently amphiphilic-they are stealth amphiphiles.

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Section: Introductionmentioning

confidence: 98%

Stealth Amphiphiles: Self-Assembly of Polyhedral Boron Clusters

et al. 2016

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“…Boron clusters have found numerous applications. − The discovery of boron clusters in the 1960s opened access to a new form of boron carrier for neutron capture therapy (NCT) of cancer . Dodecaborate anions, with their chaotropic nature, interact with proteins, carbohydrates, and membranes. − Recently, we have reported the supramolecular host–guest complexation of dodecaborate clusters of the type B 12 X 12 2– and B 12 X 11 Y 2– (X = H, Cl, Br, I and Y = OH, SH, NR 3 + ) with CDs . Strong inclusion complexes were formed, particularly with γ-CD, reaching record micromolar affinities in aqueous solution …”

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confidence: 99%

Dodecaborate-Functionalized Anchor Dyes for Cyclodextrin-Based Indicator Displacement Applications

et al. 2016

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A new type of water-soluble anchor dyes, that is, dyes which carry an auxiliary unit for strong binding to macrocyclic host molecules, has been synthesized. It consists of 7-nitrobenzofurazan (NBD) as a dye and the dodecaborate cluster (B12H11R) as a dianionic, globular, and purely inorganic anchoring group for cyclodextrins (Ka > 10(5) M(-1)). The synthesized dodecaborate-substituted dyes show marked changes in their photophysical properties (UV-vis and fluorescence) upon complexation with cyclodextrins (β-CD and γ-CD), such that the resulting host·dye complexes (1:1 stoichiometry) present sensitive reporter pairs for indicator displacement applications.

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“…Previously, we investigated the interaction of these and other boron clusters with immobilized egg phosphatidylcholine liposomes 20. We found that especially BBr and BI interacted so strongly with the liposomes that they could not be eluted, whereas BCl was not retained very strongly.…”

Section: Discussionmentioning

confidence: 94%

Halogenated Dodecaborate Clusters as Agents to Trigger Release of Liposomal Contents

et al. 2015

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Halogenated dodecaborates, and especially dodecaiodododecaborate(2−), are found to trigger effectively the release of the contents of phospholipid liposomes, including liposomes containing distearoylphosphatidylcholine and cholesterol, which are used clinically in cancer therapy. The basis of the release is studied through differential scanning calorimetry, cryo‐transmission electron microscopy, and atomic force microscopy. Upon administration at high concentrations, drastic morphological changes are induced by the dodecaborates. Their possible use in triggered release is suggested.

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Interaction of organic compounds and boron clusters with new silica matrices containing the phosphatidylcholine headgroup

Abstract: New matrices were prepared in order to understand the interaction of dodecaborate clusters with liposome surfaces. Interaction is not only through ionic forces, although the clusters are anions.

Cited by 10 publications

References 21 publications

Stealth Amphiphiles: Self-Assembly of Polyhedral Boron Clusters

Stealth Amphiphiles: Self-Assembly of Polyhedral Boron Clusters

Dodecaborate-Functionalized Anchor Dyes for Cyclodextrin-Based Indicator Displacement Applications

Halogenated Dodecaborate Clusters as Agents to Trigger Release of Liposomal Contents

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