Interaction of Olive Oil Phenol Antioxidant Components with Low-density Lipoprotein

Lamuela‐Raventós, Rosa María; Gimeno, E; Fitó, Montse; Castellote, Ana-Isabel; Covas, Maribel; Torre-Boronat, M. C. de la; López-Sabater, María-Carmen

doi:10.4067/s0716-97602004000200011

Cited by 16 publications

(11 citation statements)

References 19 publications

(7 reference statements)

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“…In a dietary intervention involving volunteers, foods rich in phenolic compounds affected LDL composition. No changes were observed in the short term, but after 1 week of olive oil consumption and following the MD, changes in the LDL composition became apparent 20 .…”

Section: Importance Of Functional Components In the Mediterranean Dietmentioning

confidence: 99%

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Importance of functional foods in the Mediterranean diet

Ortega

2006

Public Health Nutr.

154

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Objective: Analyse the importance of components of Mediterranean diet in functional feeding. Design: We have based the study in a bibliographic review. Results: Many of the characteristic components of the traditional Mediterranean diet (MD) are known to have positive effects on health, capacity and well-being, and can be used to design functional foods. Vegetables, fruits and nuts are all rich in phenols, flavonoids, isoflavonoids, phytosterols and phytic acid-essential bioactive compounds providing health benefits. The polyunsaturated fatty acids found in fish effectively regulate haemostatic factors, protect against cardiac arrhythmias, cancer and hypertension, and play a vital role in the maintenance of neural functions and the prevention of certain psychiatric disorders. Accumulating evidence suggests that olive oil, an integral component of the MD, may have health benefits, including the reduction of the risk of coronary heart disease, the prevention of several types of cancer and the modification of the immune and inflammatory responses. Olive oil is known for its high levels of monounsaturated fatty acids and is a good source of phytochemicals, such as polyphenolic compounds, squalene and a-tocopherol. In the context of the MD, the benefits associated with the consumption of several functional components may be intensified by certain forms of food preparation. In addition, the practice of more physical activity (once common among Mediterranean populations) and the following of other healthy lifestyle habits may have additive effects. Conclusions: The identification of the active constituents of the MD is crucial in the formulation of appropriate dietary guidelines. Research into the pharmacological properties of the minor components of this diet (vitamins, sterols, polyphenols, etc.) is very active and could lead to the formulation of functional foods and nutraceuticals.

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Section: Importance Of Functional Components In the Mediterranean Dietmentioning

confidence: 99%

“…. Phenolic compounds have been shown to inhibit LDL oxidation in vitro and ex vivo 20 . In a dietary intervention involving volunteers, foods rich in phenolic compounds affected LDL composition.…”

Section: Importance Of Functional Components In the Mediterranean Dietmentioning

confidence: 99%

Importance of functional foods in the Mediterranean diet

Ortega

2006

Public Health Nutr.

154

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“…Dietary antioxidants protect LDL molecules against oxidation and limit experimental atherosclerosis (19)(20)(21)(22). Abnormalities in endothelium-dependent vasodilation may in part result from the effects of oxidized LDL on nitric oxide release.…”

Section: Antioxidantsmentioning

confidence: 99%

Diet and Endothelial Function

Cuevas

Germaín

2004

Biol. Res.

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Endothelial dysfunction is one of the earliest events in atherogenesis. A consequence of endothelial damage is a lower availability of nitric oxide (NO), the most potent endogenous vasodilator. NO inhibits platelet aggregation, smooth muscle cell proliferation and adhesion of monocytes to endothelial cells. Endothelial dysfunction is present in patients with cardiovascular disease and/or coronary risk factors, such as hypertension, dyslipidemia, diabetes, smoking or hyperhomocysteinemia. At present, soluble markers and high resolution ultrasound of the brachial artery, have provided simple tools for the study of endothelial function and the effects of several interventions. It has been demonstrated that dietary factors may induce significant changes on vascular reactivity. Nutrients, such as fish oil, antioxidants, L-arginine, folic acid and soy protein have shown an improvement in endothelial function that can mediate, at least partially, the cardioprotective effects of these substances. Attention has been focused on dietary patterns in populations with lower prevalence of cardiovascular disease. There is some evidence suggesting that Mediterranean diet characterized by high consumption of vegetables, fish, olive oil and moderate wine consumption may have a positive effect on endothelial function. These results give us evidence on the significant role of diet on endothelial function and its impact on the pathogenesis of atherosclerosis.

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“…Nevertheless, its production has been reported in other Ceratocystis species, including Ceratocystis fimbriata coffea (Gremaud and Tabacchi 1996), C. clavigera, C. ips and C. huntii strains (Ayer et al 1986). Tyrosol has pharmacological interest and shows an antioxidating activity and has been used in atherosclerosis treatment, protecting low-density lipoproteins (LDL) from oxidation, which play an important role in the initiation and progress of cardiovascular disease (Ramos-Comerzana and Monteoliva-Sánchez 2000;Lamuela-Raventós et al 2004). Phytotoxic activity has also been observed in lettuce leaves and certain toxicities in mice (Ayer et al 1986).…”

Section: Compound Isolation Purification and Structural Elucidationmentioning

confidence: 96%

Tyrosol and tryptophol produced by Ceratocystis adiposa

Guzmán-López

Trigos

Fernandez

et al. 2007

World J Microbiol Biotechnol

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Extracellular tyrosol and tryptophol were produced and isolated from the phytopathogen fungus Ceratocystis adiposa cultivated in a rich broth. These compounds have not been previously reported in this Ceratocystis species, as its identification was established through spectroscopic methods ( 1 H NMR, 13 C NMR and MS). Productivity of tyrosol and tryptophol was 65.3 and 44 lg l -1 day -1 , respectively, which were values higher than those reported to date. Tyrosol is a compound of pharmaceutical interest showing antioxidating activity, a property used in the treatment of atherosclerosis. Tryptophol is reported to have antibiotic and phytotoxic activity.

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Interaction of Olive Oil Phenol Antioxidant Components with Low-density Lipoprotein

Cited by 16 publications

References 19 publications

Importance of functional foods in the Mediterranean diet

Importance of functional foods in the Mediterranean diet

Diet and Endothelial Function

Tyrosol and tryptophol produced by Ceratocystis adiposa

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