Interaction of older donor age and survival after weight-matched pediatric heart transplantation

Westbrook, Thomas; Morales, David L.S.; Khan, Muhammad S.; Bryant, Roosevelt; Castleberry, Chesney; Chin, Clifford; Zafar, Farhan

doi:10.1016/j.healun.2016.11.009

Cited by 13 publications

(24 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased use of donor organs with previously considered “marginal” characteristics may allow reduction in waitlist mortality without an effect on long‐term outcomes. However, another study demonstrated that for adolescents undergoing transplant, donors more than 25 years old resulted in worse long‐term post‐transplant survival time . As is often the case, studies continue to show seemingly conflicting results, which likely contributes to non‐uniformity between centers when deciding who is an acceptable heart donor.…”

Section: Discussionmentioning

confidence: 99%

Pediatric cardiac waitlist mortality—Still too high

Denfield

Azeka²,

Das

et al. 2020

Pediatric Transplantation

View full text Add to dashboard Cite

Cardiac transplantation for children with end‐stage cardiac disease with no other medical or surgical options is now standard. The number of children in need of cardiac transplant continues to exceed the number of donors considered “acceptable.” Therefore, there is an urgent need to understand which recipients are in greatest need of transplant before becoming “too ill” and which “marginal” donors are acceptable in order to reduce waitlist mortality. This article reviewed primarily pediatric studies reported over the last 15 years on waitlist mortality around the world for the various subgroups of children awaiting heart transplant and discusses strategies to try to reduce the cardiac waitlist mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Pediatric cardiac waitlist mortality—Still too high

Denfield

Azeka²,

Das

et al. 2020

Pediatric Transplantation

View full text Add to dashboard Cite

show abstract

“…20 Analysis of the UNOS database showed that there is some evidence that there is a difference in mortality and the development of cardiac allograft vasculopathy, especially in adolescents who receive a donor organ >5 years older than their chronological age, especially if the donor is >25 years of age. 21…”

Section: Agementioning

confidence: 99%

ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation

Kirk

Dipchand

Davies

et al. 2020

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

“…In children, Westbrook et al queried the UNOS database to determine the post‐transplant survival of weight‐matched controls with a donor age difference of more or less than 5 years . There was a significant difference in survival in those children who received a donor organ that was >5 years older than their chronological age.…”

Section: Donor Demographicsmentioning

confidence: 75%

“…In addition, those patients receiving a donor >5 years older also developed CAV earlier. Freedom from CAV at 10 years post‐transplant was 72% in those with a donor age within 5 years compared to 56% in those with an older donor …”

Section: Donor Demographicsmentioning

confidence: 99%

Review of the impact of donor characteristics on pediatric heart transplant outcomes

Conway

Ballweg

Fenton

et al. 2020

Pediatric Transplantation

View full text Add to dashboard Cite

Heart transplantation (HTx) is a treatment option for end‐stage heart failure in children. HTx is limited by the availability and acceptability of donor hearts. Refusal of donor hearts has been reported to be common with reasons for refusal including preexisting donor characteristics. This review will focus on the impact of donor characteristics and comorbidities on outcomes following pediatric HTx. A literature review was performed to identify articles on donor characteristics and comorbidities and pediatric HTx outcomes. There are many donor characteristics to consider when accepting a donor heart. Weight‐based matching is the most common form of matching in pediatric HTx with a donor‐recipient weight ratio between 0.7 and 3 having limited impact on outcomes. From an age perspective, donors <50 years can be carefully considered, but the impact of ischemic time needs to be understood. To increase the donor pool, with minimal impact on outcomes, ABO‐incompatible donors should be considered in patients that are eligible. Other factors to be considered when accepting an organ is donor comorbidities. Little is known about donor comorbidities in pediatric HTx, with most of the data available focusing on infections. Being aware of the potential infections in the donor, understanding the testing available and risks of transmission, and treatment options for the recipient is essential. There are a number of donor characteristics that potentially impact outcomes following pediatric HTx, but these need to be taken into consideration along with their interactions with recipient factors when interpreting the outcomes following HTx.

show abstract

Interaction of older donor age and survival after weight-matched pediatric heart transplantation

Cited by 13 publications

References 19 publications

Pediatric cardiac waitlist mortality—Still too high

Pediatric cardiac waitlist mortality—Still too high

ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation

Review of the impact of donor characteristics on pediatric heart transplant outcomes

Contact Info

Product

Resources

About