Interaction of nitrofurantoin with lipid langmuir monolayers as cellular membrane models distinguished with tensiometry and infrared spectroscopy

Machado, André Campos; Caseli, Luciano

doi:10.1016/j.colsurfb.2020.110794

Cited by 21 publications

(11 citation statements)

References 22 publications

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“…On the basis of the obtained data, NFT slightly interacts with the phospholipid monolayer leading to a reduction of the area per molecule over time. A similar effect has been reported in the study of Machado and Casei [1], who compared the stability curves of phospholipid DPPS with or without NFT. According to these authors, the process of relaxation in the presence of NFT causes a decrease in the monolayer surface pressures.…”

Section: Discussionsupporting

confidence: 82%

“…This effect is especially well visible for the saponins solution of 1.0 CMC. Machado and Casei [1] have shown that NFT can be incorporated in the phospholipids monolayer and form large aggregates. However, it should also be emphasized that the incorporation process may vary depending on the chemical structure of the polar head of each phospholipid.…”

Section: Discussionmentioning

confidence: 99%

“…This problem also refers to nitrofuran derivatives, which are administered to humans and animals. Their representative derivative is nitrofurantoin (NFT), which is a broad spectrum antibiotic used to treat bladder infections of humans as well as in veterinary medicine [1,2]. NFT is only partially metabolized by the mammal organisms, while the majority of the compound is excreted unchanged and goes to the sewage and to the environment.…”

Section: Introductionmentioning

confidence: 99%

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Combined Effect of Nitrofurantoin and Plant Surfactant on Bacteria Phospholipid Membrane

et al. 2020

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Due to the increasing use of antibiotics, measures are being taken to improve their removal from the natural environment. The support of biodegradation with natural surfactants that increase the bioavailability of impurities for microorganisms that degrade them, raises questions about their effect on bacterial cells. In this paper we present analysis of the interaction of nitrofurantoin (NFT) and saponins from the Saponaria officinalis on the environmental bacteria membrane and the model phospholipid membrane mimicking it. A wide perspective of the process is provided with the Langmuir monolayer technique and membrane permeability test with bacteria. The obtained results showed that above critical micelle concentration (CMC), saponin molecules are incorporated into the POPE monolayer, but the NFT impact was ambiguous. What is more, differences in membrane permeability between the cells exposed to NFT in comparison to that of the non-exposed cells were observed above 1.0 CMC for Achromobacter sp. KW1 or above 0.5 CMC for Pseudomonas sp. MChB. In both cases, NFT presence lowered the membrane permeability. Moreover, the Congo red adhesion to the cell membrane also decreased in the presence of a high concentration of surfactants and NFT. The results suggest that saponins are incorporated into the bacteria membrane, but their sugar hydrophilic part remains outside, which modifies the adsorption properties of the cell surface as well as the membrane permeability.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combined Effect of Nitrofurantoin and Plant Surfactant on Bacteria Phospholipid Membrane

et al. 2020

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“…The A/A0 parameter was, therefore, a measure of the monolayer stability. On the basis of the data in our study, nitrofurantoin was found to slightly interact with the phospholipid POPE monolayer, leading to a reduction of the area per molecule over time, which was consistent with literature reports [91]. Moreover, we also assumed that domains of saponins could be formed in the POPE monolayer, and these structures may become embedded in the monolayer, consequently changing the fluidity of the membrane.…”

Section: Application Of the Langmuir Monolayer Technique To Form Biomimetic Systemsupporting

confidence: 92%

“…The use of the Langmuir monolayer method provides data which enable a detailed description of the interactions of bacterial membrane components with antibiotics [64,117] such as pentacyclic triterpenes [118], nitrofurantoin [90,91], vancomycin [119], and antimicrobial peptides [93,120,121]. With the use of the Langmuir technique, it is possible to obtain the data that will shed light on the complexity of bacterial membrane-antibiotic interactions and be very helpful in tackling the antibiotic resistance [122], which is also an important problem in the biodegradation process [123].…”

Section: Modelling Of Cellular Membrane For Antibiotic Biodegradation Studiesmentioning

confidence: 99%

Langmuir Monolayer Techniques for the Investigation of Model Bacterial Membranes and Antibiotic Biodegradation Mechanisms

et al. 2021

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The amounts of antibiotics of anthropogenic origin released and accumulated in the environment are known to have a negative impact on local communities of microorganisms, which leads to disturbances in the course of the biodegradation process and to growing antimicrobial resistance. This mini-review covers up-to-date information regarding problems related to the omnipresence of antibiotics and their consequences for the world of bacteria. In order to understand the interaction of antibiotics with bacterial membranes, it is necessary to explain their interaction mechanism at the molecular level. Such molecular-level interactions can be probed with Langmuir monolayers representing the cell membrane. This mini-review describes monolayer experiments undertaken to investigate the impact of selected antibiotics on components of biomembranes, with particular emphasis on the role and content of individual phospholipids and lipopolysaccharides (LPS). It is shown that the Langmuir technique may provide information about the interactions between antibiotics and lipids at the mixed film surface (π–A isotherm) and about the penetration of the active substances into the phospholipid monolayer model membranes (relaxation of the monolayer). Effects induced by antibiotics on the bacterial membrane may be correlated with their bactericidal activity, which may be vital for the selection of appropriate bacterial consortia that would ensure a high degradation efficiency of pharmaceuticals in the environment.

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Dynamics of the interaction of tetracycline with a monolayer of model cell membrane using VSFG spectroscopy

Virmani

Saha²,

Sengupta³

et al. 2022

Indian J Phys

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Interaction of nitrofurantoin with lipid langmuir monolayers as cellular membrane models distinguished with tensiometry and infrared spectroscopy

Cited by 21 publications

References 22 publications

Combined Effect of Nitrofurantoin and Plant Surfactant on Bacteria Phospholipid Membrane

Combined Effect of Nitrofurantoin and Plant Surfactant on Bacteria Phospholipid Membrane

Langmuir Monolayer Techniques for the Investigation of Model Bacterial Membranes and Antibiotic Biodegradation Mechanisms

Dynamics of the interaction of tetracycline with a monolayer of model cell membrane using VSFG spectroscopy

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