Interaction of mycotoxin zearalenone with human serum albumin

Poór, Miklós; Kunsági‐Máté, Sándor; Bálint, Mónika; Hetényi, Csaba; Gerner, Zsófia; Lemli, Beáta

doi:10.1016/j.jphotobiol.2017.03.016

Cited by 56 publications

(57 citation statements)

References 39 publications

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“…If not removed during the manufacturing process, this mycotoxin affects the food chain through several food products, including maize, wheat, barley, oat and sorghum. Edible oils, nuts, spices, milk, egg, meat, wine, beer and even water can be additional routes of exposure . The wide occurrence and high thermal stability of ZEA make its elimination from the food chain very difficult …”

Section: Introductionmentioning

confidence: 99%

“…They share similar activity and molecular mechanism with estrogens. The interaction of these compounds with ERα and ERβ receptors leads to morphological and functional changes in the animal and human reproductive tract . Apart from their binding affinity to estrogen receptor, ZEA and its metabolites have been shown to be nephrotoxic, hepatotoxic, immunotoxic and genotoxic .…”

Section: Introductionmentioning

confidence: 99%

“…Edible oils, nuts, spices, milk, egg, meat, wine, beer and even water can be additional routes of exposure. [4][5][6] The wide occurrence and high thermal stability of ZEA make its elimination from the food chain very difficult. 7 Low amounts of ZEA can be transported from contaminated agricultural fields to the aquatic environment via run-off and it can be detected in a variety of waters such as groundwater, drainage water and river water, and at wastewater treatment plants.…”

Section: Introductionmentioning

confidence: 99%

“…The interaction of these compounds with ER and ER receptors leads to morphological and functional changes in the animal and human reproductive tract. 4,11,12 Apart from their binding affinity to estrogen receptor, ZEA and its metabolites have been shown to be nephrotoxic, hepatotoxic, immunotoxic and genotoxic. 13,14 Because of the serious effects of these mycotoxins in metabolism, detoxification strategies for contaminated products are of great importance for human and animal health.…”

Section: Introductionmentioning

confidence: 99%

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Biosorptive detoxification of zearalenone biotoxin by surface‐modified renewable biomass: process dynamics and application

et al. 2018

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BACKGROUND Contamination of food, feed, beverages and even drinking water with biotoxins is a growing global concern because of their potential health risks. In this work, surface‐modified sugar beet pulp waste was used for the biosorptive removal of zearalenone biotoxin from contaminated aquatic media. RESULTS Infrared, Boehm titration, BET (Brunauer–Emmett–Teller) surface area and point of zero charge analysis were employed for surface characterization. Kinetic and equilibrium studies showed that biotoxin biosorption was well predicted by the pseudo‐second‐order kinetic model and the Langmuir isotherm model. Zearalenone was removed from the solution over a wide pH range (3.0–8.0) and within a short time (15 min). Maximum uptake capacity of modified biomass was recorded as 23.30 ± 0.17 g kg−1. Highest removal yield in a dynamic flow mode (94.56 ± 0.13%) was achieved at 2 mL min−1 flow rate using 30 mg biosorbent. Regeneration experiments revealed high reusability potential of suggested biosorbent. Moreover, its application potential was tested in spiked samples of malt, beer and canned corn liquid. CONCLUSION Detoxification potential of this renewable biomass was significantly enhanced after modification. Modified biomass could be used as an efficient and low‐cost green‐type material with good application potential for zearalenone detoxification. © 2018 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biosorptive detoxification of zearalenone biotoxin by surface‐modified renewable biomass: process dynamics and application

et al. 2018

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“…Therefore, one can conclude that the main binding site for the association HSA:4c is the Sudlow's site I. 62,70 To offer a molecular level explanation on the binding ability of 4c toward HSA, theoretical studies using molecular docking calculation were performed. Figure 6 shows the molecular docking results for the interaction between HSA and 4c inside Sudlow's site I, which suggest that the hydrogen atom from the guanidinium group of Arg-221 residue is a donor for hydrogen bonding with the sulfur group present in the ligand structure, within a distance of 2.80 Å.…”

Section: Competitive Binding Studies and Theoretical Analysis On Hsa:4cmentioning

confidence: 99%

Design, Synthesis, Trypanocidal Activity, and Studies on Human Albumin Interaction of Novel S-Alkyl-1,2,4-triazoles

Franklim¹,

Freire-de-Lima²,

Chaves³

et al. 2019

J. Braz. Chem. Soc.

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Chagas disease is a neglected tropical disease caused by the hemoflagellated parasite Trypanosoma cruzi (Kinetoplastida). The only available drug to treat chagasic patients in Brazil, the nitroheterocycle benznidazole, is effective solely during the acute phase of the infection. There is accordingly a need to develop new therapeutic tools for the treatment of Chagas disease. This work reports the synthesis, trypanocidal evaluation and human serum albumin (HSA) interactions of a novel series of 1,2,4-triazoles. The new derivatives were synthesized via microwave irradiation in good yields. Most compounds showed toxic effects against T. cruzi with low toxicity to host cells. Three S-alkylated-triazoles showed the best activity profile against amastigotes, with half maximal inhibitory concentration (IC 50) values of 3.95 ± 1.41, 4.15 ± 0.92 and 3.61 ± 0.65 μmol L-1 , respectively. The interaction between HSA and 3-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-5-(butylthio)-4-cyclohexyl-4,5-dihydro-1H-1,2,4-triazole was investigated using multiple spectroscopic techniques and molecular docking, revealing that serum albumin is a potential endogenous carrier to this compound in the human bloodstream.

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