Interaction of multipotent mesenchymal stromal and immune cells: Bidirectional effects

Andreeva, E. R.; Бобылева, П. И.; Горностаева, А. Н.; Буравкова, Л. Б.

doi:10.1016/j.jcyt.2017.07.001

Cited by 43 publications

(37 citation statements)

References 120 publications

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“…33 It has been documented that MSCs play their immunomodulatory functions via cell contact or secretion of certain factors. 34 Previous investigations demonstrated that DCs are the most cells which are under immunomodulatory functions of MSCs. 35,36 Toll like receptors (TLRs) have been shown to play an essential role in inducing the immune activation program in DCs.…”

Section: Discussionmentioning

confidence: 99%

Evaluating Effect of Mesenchymal Stem Cells on Expression of TLR2 and TLR4 in Mouse DCs

Karimi¹,

Barzkar²,

Babaee³

et al. 2016

Adv Pharm Bull

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Section: Discussionmentioning

confidence: 99%

Evaluating Effect of Mesenchymal Stem Cells on Expression of TLR2 and TLR4 in Mouse DCs

Karimi¹,

Barzkar²,

Babaee³

et al. 2016

Adv Pharm Bull

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“…Having the unique capacity to modulate immune cells (25,26), MSCs are exclusive target for immunomodulation purposes (27,28). The point that these cells are almost non-immunogenic rises from the fact that MSCs only express human leukocyte antigen-I (HLA-I) and lack HLA-II and other costimulatory molecules like CD80 and CD86, needed for T cell activation (27,29). Although MSCs from different sources exert their immunomodulatory functions in different ways, the fundamental mechanism is shared among them.…”

Section: Immunomodulatory Neuroprotective and Regenerative Capacitiementioning

confidence: 99%

“…Since DCs initiate immune responses via presenting antigens to naïve T cells, they appear to be more important (25,39). MSCs inhibit monocytes from differentiation into DCs in the periphery which results into lesser induction of T cell response and cause M2 macrophage differentiation (27,40,41). The major soluble factors implicated in these events are prostaglandin E2 (PGE2), Interleukin 6 (IL-6), and macrophage colonystimulating factor (M-CSF) (25).…”

Section: Antigen-presenting Cellsmentioning

confidence: 99%

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Manipulated Mesenchymal Stem Cells Applications in Neurodegenerative Diseases

Sadatpoor

Salehi

Rahban

et al. 2020

IJSC

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Mesenchymal stem cells (MSCs) are multipotent stem cells that have multilinear differentiation and self-renewal abilities. These cells are immune-privileged as they express no or low level of class-II major histocompatibility complex (MHC-II) and other costimulatory molecules. Having neuroprotective and regenerative properties, MSCs can be used to ameliorate several intractable neurodegenerative disorders by affecting both innate and adaptive immune systems. Several manipulations like pretreating MSCs with different conditions or agents, and using molecules derived from MSCs or genetically manipulating them, are the common and practical ways that can be used to strengthen MSCs survival and potency. Improved MSCs can have significantly enhanced impacts on diseases compared to MSCs not manipulated. In this review, we describe some of the most important manipulations that have been exerted on MSCs to improve their therapeutic functions and their applications in ameliorating three prevalent neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

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“…Direct and paracrine contacts regulate the functional activity of both cell types by a feedback mechanism. 5,6 Molecular and cellular mechanisms that underlie MSC immunomodulatory effects have been studied in great detail. [7][8][9][10] MSCs can suppress the proliferation and activation of stimulated peripheral blood mononuclear cells (PBMCs)-the fraction of peripheral blood cells with round nucleus consisting of lymphocytes and monocytes.…”

mentioning

confidence: 99%

Reciprocal modulation of cell functions upon direct interaction of adipose mesenchymal stromal and activated immune cells

Бобылева

Горностаева

Andreeva

et al. 2019

Cell Biochemistry & Function

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The interaction of adipose mesenchymal stromal cells (ASCs) and allogeneic peripheral blood mononuclear cells (PBMCs) is regulated either through direct or paracrine mechanisms. Here, we examined the impact of direct contact in reciprocal regulation of ASC-PBMC functions. Activated PBMCs in vitro induced ASC immunomodulatory activity, while direct and paracrine intercellular interactions regulated PBMCs themselves: the functional state of the organelles was altered, and activation decreased.Direct contact with immune cells affected the activity of ASC intracellular compartments, in particular, reactive oxygen species (ROS) production, and decreased the growth rate. Some ASC properties, including motility, intercellular adhesion molecule-1 (ICAM-1), and major histocompatibility complex class I and II antigens (HLA-ABC and HLA-DR, respectively) expression, did not depend on contact with PBMCs and were only regulated by paracrine means. Direct ASC and PBMC contact favoured an angiogenesis-supportive microenvironment, possibly due to the greater production of VEGF by ASCs; this microenvironment also contained a higher leukemia inhibitory factor (LIF) level. Thus, a change in the functional activity of ASCs and PBMCs upon interaction promoted the formation of an immunosuppressive, anti-inflammatory, and proangiogenic microenvironment. This environment could help resolve inflammation and further restore damaged tissue.Significance of the study: Numerous studies have demonstrated the beneficial effects of transplanted mesenchymal stromal cells, particularly ASCs, for the treatment of a number of autoimmune diseases as well as various tissue injuries. To improve the efficiency of these methods, it is necessary to understand the principal events that occur when ASCs are introduced, primarily the molecular mechanisms of interaction between ASCs and the recipient immune system. We demonstrated that an anti-inflammatory, immunosuppressive, and angiostimulatory shift in the paracrine profile upon the interaction of activated PBMCs and ASCs changes the functional activity of both cell types, a phenomenon that is potentiated by direct cell-cell contact.KEYWORDS allogeneic interaction, direct and paracrine cell-cell interaction, human adipose tissue-derived stromal cells, immunomodulation, peripheral blood mononuclear cells

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Interaction of multipotent mesenchymal stromal and immune cells: Bidirectional effects

Cited by 43 publications

References 120 publications

Evaluating Effect of Mesenchymal Stem Cells on Expression of TLR2 and TLR4 in Mouse DCs

Evaluating Effect of Mesenchymal Stem Cells on Expression of TLR2 and TLR4 in Mouse DCs

Manipulated Mesenchymal Stem Cells Applications in Neurodegenerative Diseases

Reciprocal modulation of cell functions upon direct interaction of adipose mesenchymal stromal and activated immune cells

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