“…The changes in the T m values for COTAR2 and COTAR3 are similar to what would be observed bound species, such as Co(III), to a DNA oligomer alters the enthalpic contribution to the duplex stabilfor intrastrand and interstrand cross-linking by cisity. 40 The alteration may, for example, lead to stabiplatin, respectively. 41 It has been demonstrated that lization arising from the resultant favorable electrocisplatin preferentially cross-links DNA in an intrastatic interaction or destabilization arising from hestrand fashion at GG sites and, to a lesser extent, lix distortion at the point of coordination.…”