Interaction of methylmercury chloride with cellular energetics and related processes

Ally, A.I.; Phipps, J.; Miller, Don R.

doi:10.1016/0041-008x(84)90001-2

Cited by 17 publications

(11 citation statements)

References 24 publications

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“…34 No. 3 et al, 2003;Hunter and Brown, 2000;Miura et al, 1999;Mottet et al, 1997), resulting in alteration of gene expres- Naganuma et al, 2002;Díaz et al, 2004;Baraldi et al, 2002), and to impaired mitochondrial functions (Ally et al, 1984;Mori et al, 2007;Garg and Chang, 2006;Morken et al, 2005;Fonfría et al, 2002;Ahlbom et al, 2000;Atchison and Hare, 1994). In each report, ROS played a crucial role in mediating MeHg toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…2D). We investigated whether this time delay could be extended by exposing cells to antioxidants, given that previous reports have shown that MeHg induces cell death via the generation of reactive oxygen spieces (ROS) (Ally et al, 1984;Mori et al, 2007;Garg and Chang, 2006;Morken et al, 2005;Fonfría et al, 2002;Ahlbom et al, 2000;Atchison and Hare, 1994). Pre-treatment of tNPC with either of two antioxidants, N-acetyl cysteine (NAC) (Fig.…”

Section: Antioxidants Rescue Tnpc From Mehg-induced Cell Deathmentioning

confidence: 99%

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Characterization of antioxidant protection of cultured neural progenitor cells (NPC) against methylmercury (MeHg) toxicity

et al. 2009

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-Methylmercury (MeHg) is an environmental pollutant known to cause neurobehavioral defects and is especially toxic to the developing brain. With recent studies showing that fetal exposure -bat its effects as well as to clarify the mechanism(s) underlying MeHg toxicity. In the present study, the effects of MeHg on cultured neural progenitor cells (NPC) derived from mouse embryonic brain were -encephalon were more sensitive to MeHg compared to those from the diencephalon. Buthionine sulfoximine (BSO) which is known to inhibit glutathione synthesis accelerated MeHg toxicity. Furthermore, -ic effects. Interestingly, a 12 hr delay in the addition of either antioxidant was still able to prevent the cells and contaminated foods, taking anti-oxidants from foods or supplements may prevent or diminish the toxicological effects of MeHg.

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Section: Discussionmentioning

confidence: 99%

Section: Antioxidants Rescue Tnpc From Mehg-induced Cell Deathmentioning

confidence: 99%

Characterization of antioxidant protection of cultured neural progenitor cells (NPC) against methylmercury (MeHg) toxicity

et al. 2009

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“…Others have described impairment of protein synthesis in cell cultures exposed to methyl mercury in vitro (Nakada et al 1980;Gruenwedel et al 1981;Ally et al 1984) and in rat tissue after in vivo exposure (Brubaker et al 1973). The inhibitory effect of inorganic mercury and methyl mercury on protein synthesis is similar in mouse glioma cells, while inorganic mercury has an inhibitory effect 10 times stronger than methyl mercury in cell free systems prepared from mouse glioma cells (Nakada et al 1980).…”

Section: Discussionmentioning

confidence: 93%

Comparison of the interaction of methyl mercury and mercuric chloride with murine macrophages

et al. 1993

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The toxicity of organic methyl mercury was studied on murine macrophages in cell culture and compared to that of inorganic mercuric chloride. Long-term treatment of macrophage cultures with methyl mercury resulted in decreased cell viability in a concentration-dependent fashion. Experiments showed that 20 microM methyl mercury was highly toxic, causing cell death within a few days, while cultures exposed to lower levels were less severely affected. Comparison of the toxicity of organic and inorganic mercury by cell viability showed no difference between equimolar concentrations of methyl mercury and mercuric chloride. Furthermore, protein synthesis (interferon-alpha/beta) was reduced in a concentration dependent manner and had the same reduced magnitude in cells treated with either methyl mercury or mercuric chloride. However, impairment of random migration and phagocytosis of macrophages appeared at lower concentrations in cells exposed to methyl mercury than in cells exposed to mercuric chloride. Electron microscopy of cells exposed to methyl mercury revealed mercury deposits in lysosomes and dispersed in the cytoplasm and nuclei. The present study shows that methyl mercury and mercuric chloride impair cell viability and protein production in cell cultures at equimolar concentrations, while methyl mercury inhibits macrophage functions such as migration and phagocytosis at lower concentrations than mercuric chloride.

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“…Past experiments indicate that MeHg can interfere with Ca>-mediated synaptic mechanisms and cellular aerobic respiration (Atchison and Narahashi, 1982;Atchison, 1986Atchison, , 1987Atchison, , 1988McKay et al, 1986;Levesque and Atchison, 1988;Kauppinen et al, 1989;Komulainen and Bondy, 1987;Levesque et al, 1992;Ahammadsahib et al, 1987;Ally et al, 1984;Yee and Choi, 1992). Results from presynaptic recordings indicated that 50 M MeHg suppressed both presynaptic and postsynaptic excitability.…”

Section: Discussionmentioning

confidence: 94%

“…Evidence from studies of neuromuscular junction and cerebrocortical synaptosomes suggests that MeHg interferes with Ca>-mediated synaptic mechanisms via effects on Ca> stores within the nerve terminal ([Ca>] ) (Atchison and Narahashi, 1982;Atchison, 1986Atchison, , 1987Atchison, , 1988McKay et al, 1986;Levesque and Atchison, 1988;Kauppinen et al, 1989;Komulainen and Bondy, 1987;Levesque et al, 1992). Other experiments suggest that MeHg interferes with cellular aerobic respiration (Ahammadsahib et al, 1987;Ally et al, 1984;Yee and Choi, 1992).…”

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confidence: 92%

Effects of Sequential Exposure to Multiple Concentrations of Methylmercury in the Rat Hippocampal Slice

Fountain

Rowan

2000

Ecotoxicology and Environmental Safety

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Interaction of methylmercury chloride with cellular energetics and related processes

Cited by 17 publications

References 24 publications

Characterization of antioxidant protection of cultured neural progenitor cells (NPC) against methylmercury (MeHg) toxicity

Characterization of antioxidant protection of cultured neural progenitor cells (NPC) against methylmercury (MeHg) toxicity

Comparison of the interaction of methyl mercury and mercuric chloride with murine macrophages

Effects of Sequential Exposure to Multiple Concentrations of Methylmercury in the Rat Hippocampal Slice

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